| 08 Oct 10 | r01        | GlasgowGlasgow | 21 - 13 | DragonsDragons |
| 08 Oct 10 | r01        | UlsterUlster | 30 - 6 | AironiAironi |
| 08 Oct 10 | r01        | Northampton SaintsNorthampton S | 18 - 14 | Castres OlympiqueCastres Olymp |
| 09 Oct 10 | r01        | BenettonBenetton | 29 - 34 | Leicester TigersLeicester Tig |
| 09 Oct 10 | r01        | LeinsterLeinster | 38 - 22 | Racing Métro 92Racing Métro |
| 09 Oct 10 | r01        | RC ToulonnaisRC Toulonnais | 19 - 14 | OspreysOspreys |
| 09 Oct 10 | r01        | ASM Clermont AuvergneASM Clermont | 25 - 10 | SaracensSaracens |
| 09 Oct 10 | r01        | ScarletsScarlets | 43 - 34 | USA PerpignanUSA Perpignan |
| 09 Oct 10 | r01        | Cardiff BluesCardiff Blues | 18 - 17 | EdinburghEdinburgh |
| 09 Oct 10 | r01        | London IrishLondon Irish | 23 - 17 | MunsterMunster |
| 10 Oct 10 | r01        | Bath RugbyBath Rugby | 11 - 12 | Biarritz OlympiqueBiarritz Olym |
| 10 Oct 10 | r01        | Stade ToulousainStade Toulous | 18 - 16 | WaspsWasps |