| 22 Jan 10 | r06        | MunsterMunster | 12 - 9 | Northampton SaintsNorthampton S |
| 22 Jan 10 | r06        | USA PerpignanUSA Perpignan | 34 - 6 | BenettonBenetton |
| 23 Jan 10 | r06        | OspreysOspreys | 17 - 12 | Leicester TigersLeicester Tig |
| 23 Jan 10 | r06        | Rugby ViadanaRugby Viadana | 20 - 59 | ASM Clermont AuvergneASM Clermont |
| 23 Jan 10 | r06        | Bath RugbyBath Rugby | 10 - 28 | UlsterUlster |
| 23 Jan 10 | r06        | EdinburghEdinburgh | 9 - 7 | Stade Français ParisStade Françai |
| 23 Jan 10 | r06        | CA BriveCA Brive | 17 - 20 | ScarletsScarlets |
| 23 Jan 10 | r06        | London IrishLondon Irish | 11 - 11 | LeinsterLeinster |
| 24 Jan 10 | r06        | Biarritz OlympiqueBiarritz Olym | 41 - 20 | GlasgowGlasgow |
| 24 Jan 10 | r06        | DragonsDragons | 23 - 32 | GloucesterGloucester |
| 24 Jan 10 | r06        | HarlequinsHarlequins | 20 - 45 | Cardiff BluesCardiff Blues |
| 24 Jan 10 | r06        | Sale SharksSale Sharks | 13 - 19 | Stade ToulousainStade Toulous |