| 18 Jan 22 | r10        | BC LietkabelisBC Lietkabeli | 88 - 65 | Śląsk WrocławŚląsk Wrocław |
| 18 Jan 22 | r10        | Reyer Venezia MestreReyer Venezia | 78 - 81 | Bourg-en-BresseBourg-en-Bres |
| 18 Jan 22 | r10        | Joventut BadalonaJoventut Bada | 82 - 65 | Aquila Basket TrentoAquila Basket |
| 18 Jan 22 | r10        | KK PartizanKK Partizan | 102 - 77 | Hamburg TowersHamburg Tower |
| 19 Jan 22 | r10        | Promitheas Patras BCPromitheas Pa | 68 - 71 | Valencia BasketValencia Bask |
| 19 Jan 22 | r10        | KK BudućnostKK Budućnost | 68 - 89 | UlmUlm |
| 19 Jan 22 | r10        | BC AndorraBC Andorra | 76 - 86 | PBC Lokomotiv KubanPBC Lokomotiv |
| 19 Jan 22 | r10        | KK Cedevita OlimpijaKK Cedevita O | 60 - 75 | CB Gran CanariaCB Gran Canar |
| 19 Jan 22 | r10        | Metropolitans 92Metropolitans | 99 - 82 | Türk Telekom BKTürk Telekom |
| 19 Jan 22 | r10        | Virtus Pallacanestro BoloVirtus Pallac | P - P | Bursaspor BasketbolBursaspor Bas |
| 25 Jan 22 | r10        | Türk Telekom BKTürk Telekom | 85 - 71 | KK PartizanKK Partizan |
| 25 Jan 22 | r10        | UlmUlm | 84 - 68 | Virtus Pallacanestro BoloVirtus Pallac |
| 25 Jan 22 | r10        | Śląsk WrocławŚląsk Wrocław | 59 - 74 | Metropolitans 92Metropolitans |
| 25 Jan 22 | r10        | Valencia BasketValencia Bask | 103 - 76 | KK BudućnostKK Budućnost |
| 26 Jan 22 | r10        | PBC Lokomotiv KubanPBC Lokomotiv | 90 - 62 | BC LietkabelisBC Lietkabeli |
| 26 Jan 22 | r10        | Bursaspor BasketbolBursaspor Bas | P - P | Reyer Venezia MestreReyer Venezia |
| 26 Jan 22 | r10        | Hamburg TowersHamburg Tower | 75 - 92 | Joventut BadalonaJoventut Bada |
| 26 Jan 22 | r10        | Bourg-en-BresseBourg-en-Bres | 76 - 69 | KK Cedevita OlimpijaKK Cedevita O |
| 26 Jan 22 | r10        | Aquila Basket TrentoAquila Basket | 71 - 82 | BC AndorraBC Andorra |
| 26 Jan 22 | r10        | CB Gran CanariaCB Gran Canar | 81 - 62 | Promitheas Patras BCPromitheas Pa |