| 11 Jan 22 | r09        | Hamburg TowersHamburg Tower | 94 - 74 | Türk Telekom BKTürk Telekom |
| 11 Jan 22 | r09        | BC AndorraBC Andorra | P - P | Śląsk WrocławŚląsk Wrocław |
| 11 Jan 22 | r09        | Reyer Venezia MestreReyer Venezia | P - P | CB Gran CanariaCB Gran Canar |
| 12 Jan 22 | r09        | BC LietkabelisBC Lietkabeli | 96 - 89 | Metropolitans 92Metropolitans |
| 12 Jan 22 | r09        | KK BudućnostKK Budućnost | - | Bursaspor BasketbolBursaspor Bas |
| 12 Jan 22 | r09        | UlmUlm | 70 - 76 | Valencia BasketValencia Bask |
| 12 Jan 22 | r09        | KK Cedevita OlimpijaKK Cedevita O | - | Promitheas Patras BCPromitheas Pa |
| 12 Jan 22 | r09        | KK PartizanKK Partizan | 97 - 65 | Aquila Basket TrentoAquila Basket |
| 12 Jan 22 | r09        | Virtus Pallacanestro BoloVirtus Pallac | 83 - 82 | Bourg-en-BresseBourg-en-Bres |
| 12 Jan 22 | r09        | Joventut BadalonaJoventut Bada | 100 - 77 | PBC Lokomotiv KubanPBC Lokomotiv |