| 05 Feb 22 | r01    | Loughborough LightningLoughborough | - | London PulseLondon Pulse |
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| 12 Feb 22 | r03 | Loughborough LightningLoughborough | 65 - 37 | Celtic DragonsCeltic Dragon |
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| 21 Feb 22 | r04 | Surrey StormSurrey Storm | 56 - 72 | Loughborough LightningLoughborough |
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| 25 Feb 22 | r05 | Sirens NetballSirens Netbal | 48 - 61 | Loughborough LightningLoughborough |
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| 05 Mar 22 | r06 | Loughborough LightningLoughborough | 70 - 47 | Saracens MavericksSaracens Mave |
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| 13 Mar 22 | r08 | Loughborough LightningLoughborough | 57 - 53 | Wasps NetballWasps Netball |
| 14 Mar 22 | r08 | Team BathTeam Bath | 44 - 53 | Loughborough LightningLoughborough |
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| 19 Mar 22 | r09 | Severn StarsSevern Stars | 56 - 70 | Loughborough LightningLoughborough |
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| 28 Mar 22 | r10 | Loughborough LightningLoughborough | 61 - 66 | Manchester ThunderManchester Th |
| 02 Apr 22 | r10 | London PulseLondon Pulse | 44 - 64 | Loughborough LightningLoughborough |
| 04 Apr 22 | r10 | Loughborough LightningLoughborough | 62 - 54 | Leeds Rhinos NetballLeeds Rhinos |
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| 16 Apr 22 | r13 | Loughborough LightningLoughborough | 57 - 54 | Surrey StormSurrey Storm |
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| 17 Apr 22 | r14 | Celtic DragonsCeltic Dragon | 52 - 56 | Loughborough LightningLoughborough |
| |
| 23 Apr 22 | r15 | Loughborough LightningLoughborough | 52 - 46 | Sirens NetballSirens Netbal |
| |
| 02 May 22 | r16 | Saracens MavericksSaracens Mave | 51 - 59 | Loughborough LightningLoughborough |
| |
| 09 May 22 | r17 | Loughborough LightningLoughborough | 52 - 46 | Team BathTeam Bath |
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| 21 May 22 | r19 | Loughborough LightningLoughborough | 66 - 46 | Severn StarsSevern Stars |
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| 30 May 22 | r20 | Manchester ThunderManchester Th | 71 - 63 | Loughborough LightningLoughborough |
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| 03 Jun 22 | SF | Loughborough LightningLoughborough | 56 - 44 | London PulseLondon Pulse |
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| 05 Jun 22 | Final | Manchester ThunderManchester Th | 60 - 53 | Loughborough LightningLoughborough |
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