| 10 Sep 21 | r01   | Paris Saint-Germain HandbParis Saint-G | 34 - 25 | Istres Provence HandballIstres Proven |
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| 18 Sep 21 | r02 | Istres Provence HandballIstres Proven | 23 - 29 | Montpellier HandballMontpellier H |
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| 24 Sep 21 | r03 | Istres Provence HandballIstres Proven | 29 - 29 | C Chartres Métropole HandC Chartres Mé |
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| 01 Oct 21 | r04 | Limoges HandballLimoges Handb | 34 - 37 | Istres Provence HandballIstres Proven |
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| 08 Oct 21 | r05 | Istres Provence HandballIstres Proven | 28 - 30 | PAUC HandballPAUC Handball |
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| 14 Oct 21 | r06 | Saran Loiret HBSaran Loiret | 29 - 27 | Istres Provence HandballIstres Proven |
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| 21 Oct 21 | r07 | Chambéry Savoie HandballChambéry Savo | 34 - 27 | Istres Provence HandballIstres Proven |
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| 31 Oct 21 | r08 | Istres Provence HandballIstres Proven | 29 - 29 | USAM Nîmes GardUSAM Nîmes Ga |
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| 13 Nov 21 | r09 | HBC NantesHBC Nantes | 36 - 31 | Istres Provence HandballIstres Proven |
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| 18 Nov 21 | r10 | Istres Provence HandballIstres Proven | 22 - 30 | Dunkerque Handball Grand Dunkerque Han |
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| 26 Nov 21 | r11 | Grand Nancy Métropole HBGrand Nancy M | 23 - 27 | Istres Provence HandballIstres Proven |
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| 09 Dec 21 | r13 | Cesson Rennes MHBCesson Rennes | 30 - 30 | Istres Provence HandballIstres Proven |
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| 14 Dec 21 | r14 | Istres Provence HandballIstres Proven | 26 - 26 | US Créteil HandballUS Créteil Ha |
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| 05 Feb 22 | r15 | Fenix Toulouse HandballFenix Toulous | 30 - 25 | Istres Provence HandballIstres Proven |
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| 11 Feb 22 | r16 | Istres Provence HandballIstres Proven | 28 - 37 | Paris Saint-Germain HandbParis Saint-G |
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| 25 Feb 22 | r18 | Istres Provence HandballIstres Proven | 28 - 32 | HBC NantesHBC Nantes |
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| 03 Mar 22 | r19 | Istres Provence HandballIstres Proven | 27 - 32 | Limoges HandballLimoges Handb |
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| 11 Mar 22 | r20 | Dunkerque Handball Grand Dunkerque Han | 31 - 22 | Istres Provence HandballIstres Proven |
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| 26 Mar 22 | r21 | Istres Provence HandballIstres Proven | 27 - 30 | Fenix Toulouse HandballFenix Toulous |
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| 29 Mar 22 | r12 | Istres Provence HandballIstres Proven | 26 - 27 | Saint-Raphaël Var HandbalSaint-Raphaël |
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| 03 Apr 22 | r22 | Montpellier HandballMontpellier H | 35 - 32 | Istres Provence HandballIstres Proven |
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| 07 Apr 22 | r23 | Istres Provence HandballIstres Proven | 25 - 32 | Chambéry Savoie HandballChambéry Savo |
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| 23 Apr 22 | r17 | Saint-Raphaël Var HandbalSaint-Raphaël | 31 - 31 | Istres Provence HandballIstres Proven |
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| 29 Apr 22 | r24 | C Chartres Métropole HandC Chartres Mé | 34 - 30 | Istres Provence HandballIstres Proven |
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| 07 May 22 | r25 | Istres Provence HandballIstres Proven | 27 - 20 | Saran Loiret HBSaran Loiret |
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| 19 May 22 | r26 | PAUC HandballPAUC Handball | - | Istres Provence HandballIstres Proven |
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| 26 May 22 | r27 | USAM Nîmes GardUSAM Nîmes Ga | - | Istres Provence HandballIstres Proven |
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| 01 Jun 22 | r28 | Istres Provence HandballIstres Proven | 29 - 28 | Cesson Rennes MHBCesson Rennes |
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| 04 Jun 22 | r29 | US Créteil HandballUS Créteil Ha | - | Istres Provence HandballIstres Proven |
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| 07 Jun 22 | r30 | Istres Provence HandballIstres Proven | - | Grand Nancy Métropole HBGrand Nancy M |
Team 2021-2022 Schedules
C Chartres Métropole Handball
Cesson Rennes MHB
Chambéry Savoie Handball
Dijon Bourgogne
Dunkerque Handball Grand Littoral
Fenix Toulouse Handball
HBC Nantes
Istres Provence Handball
Limoges Handball
Montpellier Handball
Paris Saint-Germain Handball
PAUC Handball
Saint-Raphaël Var Handball
Sélestat Alsace Handball
Tremblay-en-France Handball
USAM Nîmes Gard
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