| 03 Sep 22 | r01        | Rhein-Neckar LöwenRhein-Neckar | 36 - 25 | MT MelsungenMT Melsungen |
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| 08 Sep 22 | r02        | ASV Hamm-WestfalenASV Hamm-West | 30 - 35 | Rhein-Neckar LöwenRhein-Neckar |
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| 15 Sep 22 | r03        | Rhein-Neckar LöwenRhein-Neckar | 30 - 24 | SC DHfK LeipzigSC DHfK Leipz |
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| 17 Sep 22 | r04        | TVB 1898 StuttgartTVB 1898 Stut | 30 - 43 | Rhein-Neckar LöwenRhein-Neckar |
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| 24 Sep 22 | r05        | Rhein-Neckar LöwenRhein-Neckar | 28 - 27 | SG Flensburg-HandewittSG Flensburg- |
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| 29 Sep 22 | r06        | Bergischer HCBergischer HC | 26 - 27 | Rhein-Neckar LöwenRhein-Neckar |
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| 06 Oct 22 | r07        | Rhein-Neckar LöwenRhein-Neckar | 37 - 25 | GWD MindenGWD Minden |
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| 23 Oct 22 | r08        | THW KielTHW Kiel | 32 - 29 | Rhein-Neckar LöwenRhein-Neckar |
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| 30 Oct 22 | r09        | Rhein-Neckar LöwenRhein-Neckar | 32 - 31 | TSV Hannover-BurgdorfTSV Hannover- |
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| 06 Nov 22 | r10        | Handball Sport Verein HamHandball Spor | 40 - 37 | Rhein-Neckar LöwenRhein-Neckar |
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| 09 Nov 22 | r11        | SC MagdeburgSC Magdeburg | 32 - 32 | Rhein-Neckar LöwenRhein-Neckar |
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| 13 Nov 22 | r12        | Rhein-Neckar LöwenRhein-Neckar | 37 - 28 | TBV LemgoTBV Lemgo |
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| 19 Nov 22 | r13        | HC ErlangenHC Erlangen | 30 - 33 | Rhein-Neckar LöwenRhein-Neckar |
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| 24 Nov 22 | r14        | Rhein-Neckar LöwenRhein-Neckar | 32 - 34 | Füchse BerlinFüchse Berlin |
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| 01 Dec 22 | r15        | VfL GummersbachVfL Gummersba | 29 - 32 | Rhein-Neckar LöwenRhein-Neckar |
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| 11 Dec 22 | r16        | Rhein-Neckar LöwenRhein-Neckar | 36 - 33 | TPSG Frisch Auf GöppingenTPSG Frisch A |
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| 18 Dec 22 | r17        | HSG WetzlarHSG Wetzlar | 23 - 29 | Rhein-Neckar LöwenRhein-Neckar |
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| 26 Dec 22 | r18        | Rhein-Neckar LöwenRhein-Neckar | 37 - 27 | ASV Hamm-WestfalenASV Hamm-West |
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| 09 Feb 23 | r19        | GWD MindenGWD Minden | 29 - 40 | Rhein-Neckar LöwenRhein-Neckar |
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| 19 Feb 23 | r20        | Rhein-Neckar LöwenRhein-Neckar | 41 - 27 | TVB 1898 StuttgartTVB 1898 Stut |
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| 25 Feb 23 | r21        | TPSG Frisch Auf GöppingenTPSG Frisch A | 25 - 27 | Rhein-Neckar LöwenRhein-Neckar |
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| 02 Mar 23 | r22        | Rhein-Neckar LöwenRhein-Neckar | 34 - 24 | HSG WetzlarHSG Wetzlar |
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| 16 Mar 23 | r23        | SC DHfK LeipzigSC DHfK Leipz | 37 - 29 | Rhein-Neckar LöwenRhein-Neckar |
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| 23 Mar 23 | r24        | Rhein-Neckar LöwenRhein-Neckar | 32 - 35 | Handball Sport Verein HamHandball Spor |
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| 30 Mar 23 | r25        | TBV LemgoTBV Lemgo | 33 - 30 | Rhein-Neckar LöwenRhein-Neckar |
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| 09 Apr 23 | r26        | Rhein-Neckar LöwenRhein-Neckar | 37 - 42 | VfL GummersbachVfL Gummersba |
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| 23 Apr 23 | r27        | Füchse BerlinFüchse Berlin | 38 - 24 | Rhein-Neckar LöwenRhein-Neckar |
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| 03 May 23 | r28        | Rhein-Neckar LöwenRhein-Neckar | 27 - 31 | THW KielTHW Kiel |
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| 14 May 23 | r30        | Rhein-Neckar LöwenRhein-Neckar | 35 - 37 | SC MagdeburgSC Magdeburg |
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| 21 May 23 | r31        | TSV Hannover-BurgdorfTSV Hannover- | 30 - 31 | Rhein-Neckar LöwenRhein-Neckar |
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| 25 May 23 | r29        | MT MelsungenMT Melsungen | 25 - 34 | Rhein-Neckar LöwenRhein-Neckar |
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| 01 Jun 23 | r33        | Rhein-Neckar LöwenRhein-Neckar | 39 - 29 | Bergischer HCBergischer HC |
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| 04 Jun 23 | r32        | Rhein-Neckar LöwenRhein-Neckar | 40 - 23 | HC ErlangenHC Erlangen |
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| 11 Jun 23 | r34        | SG Flensburg-HandewittSG Flensburg- | 34 - 31 | Rhein-Neckar LöwenRhein-Neckar |