| 09 Sep 21 | r01        | SC MagdeburgSC Magdeburg | 33 - 29 | TVB 1898 StuttgartTVB 1898 Stut |
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| 16 Sep 21 | r03        | TVB 1898 StuttgartTVB 1898 Stut | 27 - 34 | TPSG Frisch Auf GöppingenTPSG Frisch A |
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| 23 Sep 21 | r04        | Bergischer HCBergischer HC | 26 - 25 | TVB 1898 StuttgartTVB 1898 Stut |
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| 26 Sep 21 | r10        | TVB 1898 StuttgartTVB 1898 Stut | 26 - 34 | Handball Sport Verein HamHandball Spor |
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| 03 Oct 21 | r05        | TVB 1898 StuttgartTVB 1898 Stut | 35 - 30 | Rhein-Neckar LöwenRhein-Neckar |
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| 10 Oct 21 | r06        | SC DHfK LeipzigSC DHfK Leipz | 33 - 24 | TVB 1898 StuttgartTVB 1898 Stut |
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| 17 Oct 21 | r07        | TVB 1898 StuttgartTVB 1898 Stut | 27 - 26 | HBW Balingen-WeilstettenHBW Balingen- |
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| 24 Oct 21 | r08        | SG Flensburg-HandewittSG Flensburg- | 30 - 29 | TVB 1898 StuttgartTVB 1898 Stut |
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| 31 Oct 21 | r09        | HSG WetzlarHSG Wetzlar | 35 - 34 | TVB 1898 StuttgartTVB 1898 Stut |
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| 13 Nov 21 | r11        | MT MelsungenMT Melsungen | 29 - 23 | TVB 1898 StuttgartTVB 1898 Stut |
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| 21 Nov 21 | r12        | TVB 1898 StuttgartTVB 1898 Stut | 32 - 32 | Füchse BerlinFüchse Berlin |
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| 25 Nov 21 | r13        | HC ErlangenHC Erlangen | 27 - 32 | TVB 1898 StuttgartTVB 1898 Stut |
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| 02 Dec 21 | r14        | TVB 1898 StuttgartTVB 1898 Stut | 35 - 31 | GWD MindenGWD Minden |
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| 09 Dec 21 | r15        | TuS Nettelstedt-LübbeckeTuS Nettelste | 27 - 23 | TVB 1898 StuttgartTVB 1898 Stut |
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| 12 Dec 21 | r02        | TVB 1898 StuttgartTVB 1898 Stut | 22 - 34 | TSV Hannover-BurgdorfTSV Hannover- |
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| 18 Dec 21 | r16        | TVB 1898 StuttgartTVB 1898 Stut | 37 - 40 | TBV LemgoTBV Lemgo |
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| 22 Dec 21 | r17        | THW KielTHW Kiel | 35 - 31 | TVB 1898 StuttgartTVB 1898 Stut |
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| 26 Dec 21 | r18        | TPSG Frisch Auf GöppingenTPSG Frisch A | 34 - 32 | TVB 1898 StuttgartTVB 1898 Stut |
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| 10 Feb 22 | r19        | TVB 1898 StuttgartTVB 1898 Stut | 29 - 42 | THW KielTHW Kiel |
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| 20 Feb 22 | r21        | Füchse BerlinFüchse Berlin | 29 - 22 | TVB 1898 StuttgartTVB 1898 Stut |
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| 26 Feb 22 | r22        | TVB 1898 StuttgartTVB 1898 Stut | 27 - 26 | Bergischer HCBergischer HC |
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| 03 Mar 22 | r23        | TVB 1898 StuttgartTVB 1898 Stut | 26 - 26 | HSG WetzlarHSG Wetzlar |
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| 13 Mar 22 | r24        | TVB 1898 StuttgartTVB 1898 Stut | 27 - 30 | SC MagdeburgSC Magdeburg |
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| 24 Mar 22 | r25        | TSV Hannover-BurgdorfTSV Hannover- | 33 - 23 | TVB 1898 StuttgartTVB 1898 Stut |
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| 31 Mar 22 | r26        | TVB 1898 StuttgartTVB 1898 Stut | 34 - 29 | HC ErlangenHC Erlangen |
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| 07 Apr 22 | r27        | HBW Balingen-WeilstettenHBW Balingen- | 25 - 28 | TVB 1898 StuttgartTVB 1898 Stut |
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| 21 Apr 22 | r31        | Rhein-Neckar LöwenRhein-Neckar | 28 - 23 | TVB 1898 StuttgartTVB 1898 Stut |
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| 01 May 22 | r28        | TVB 1898 StuttgartTVB 1898 Stut | 29 - 25 | SC DHfK LeipzigSC DHfK Leipz |
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| 08 May 22 | r29        | GWD MindenGWD Minden | 25 - 26 | TVB 1898 StuttgartTVB 1898 Stut |
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| 15 May 22 | r20        | TBV LemgoTBV Lemgo | 33 - 30 | TVB 1898 StuttgartTVB 1898 Stut |
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| 26 May 22 | r30        | TVB 1898 StuttgartTVB 1898 Stut | 26 - 28 | SG Flensburg-HandewittSG Flensburg- |
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| 02 Jun 22 | r32        | TVB 1898 StuttgartTVB 1898 Stut | 29 - 31 | TuS Nettelstedt-LübbeckeTuS Nettelste |
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| 09 Jun 22 | r33        | Handball Sport Verein HamHandball Spor | 27 - 32 | TVB 1898 StuttgartTVB 1898 Stut |
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| 12 Jun 22 | r34        | TVB 1898 StuttgartTVB 1898 Stut | 28 - 25 | MT MelsungenMT Melsungen |