| 04 Oct 20 | r01        | Rhein-Neckar LöwenRhein-Neckar | 30 - 20 | TVB 1898 StuttgartTVB 1898 Stut |
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| 06 Oct 20 | r02        | TSG FriesenheimTSG Friesenhe | 24 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 11 Oct 20 | r03        | Rhein-Neckar LöwenRhein-Neckar | 33 - 27 | TUSEM EssenTUSEM Essen |
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| 15 Oct 20 | r04        | Rhein-Neckar LöwenRhein-Neckar | 23 - 28 | SC DHfK LeipzigSC DHfK Leipz |
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| 25 Oct 20 | r05        | HC ErlangenHC Erlangen | 20 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 01 Nov 20 | r06        | Rhein-Neckar LöwenRhein-Neckar | 36 - 27 | HBW Balingen-WeilstettenHBW Balingen- |
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| 11 Nov 20 | r07        | SC MagdeburgSC Magdeburg | 31 - 33 | Rhein-Neckar LöwenRhein-Neckar |
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| 14 Nov 20 | r08        | Rhein-Neckar LöwenRhein-Neckar | 26 - 18 | TBV LemgoTBV Lemgo |
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| 26 Nov 20 | r10        | Rhein-Neckar LöwenRhein-Neckar | 37 - 24 | HSG WetzlarHSG Wetzlar |
| 06 Dec 20 | r10        | HSG Nordhorn-LingenHSG Nordhorn- | 24 - 29 | Rhein-Neckar LöwenRhein-Neckar |
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| 13 Dec 20 | r12        | Rhein-Neckar LöwenRhein-Neckar | 31 - 31 | SG Flensburg-HandewittSG Flensburg- |
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| 15 Dec 20 | r13        | TSV Hannover-BurgdorfTSV Hannover- | 36 - 30 | Rhein-Neckar LöwenRhein-Neckar |
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| 20 Dec 20 | r14        | Rhein-Neckar LöwenRhein-Neckar | 24 - 23 | Bergischer HCBergischer HC |
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| 23 Dec 20 | r15        | THW KielTHW Kiel | 32 - 23 | Rhein-Neckar LöwenRhein-Neckar |
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| 27 Dec 20 | r16        | Rhein-Neckar LöwenRhein-Neckar | 39 - 24 | HSC 2000 CoburgHSC 2000 Cobu |
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| 14 Feb 21 | r18        | TPSG Frisch Auf GöppingenTPSG Frisch A | 34 - 32 | Rhein-Neckar LöwenRhein-Neckar |
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| 21 Feb 21 | r19        | Füchse BerlinFüchse Berlin | 23 - 29 | Rhein-Neckar LöwenRhein-Neckar |
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| 28 Feb 21 | r09        | GWD MindenGWD Minden | 26 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 06 Mar 21 | r20        | Rhein-Neckar LöwenRhein-Neckar | 31 - 32 | TPSG Frisch Auf GöppingenTPSG Frisch A |
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| 18 Mar 21 | r21        | Rhein-Neckar LöwenRhein-Neckar | 31 - 27 | TSG FriesenheimTSG Friesenhe |
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| 21 Mar 21 | r20        | SC DHfK LeipzigSC DHfK Leipz | 26 - 33 | Rhein-Neckar LöwenRhein-Neckar |
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| 27 Mar 21 | r23        | Rhein-Neckar LöwenRhein-Neckar | 29 - 27 | GWD MindenGWD Minden |
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| 01 Apr 21 | r17        | MT MelsungenMT Melsungen | 25 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 04 Apr 21 | r24        | HSG WetzlarHSG Wetzlar | 34 - 32 | Rhein-Neckar LöwenRhein-Neckar |
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| 08 Apr 21 | r32        | Rhein-Neckar LöwenRhein-Neckar | 30 - 26 | HSG Nordhorn-LingenHSG Nordhorn- |
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| 11 Apr 21 | r25        | HSC 2000 CoburgHSC 2000 Cobu | 28 - 31 | Rhein-Neckar LöwenRhein-Neckar |
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| 17 Apr 21 | r26        | Rhein-Neckar LöwenRhein-Neckar | 33 - 28 | TSV Hannover-BurgdorfTSV Hannover- |
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| 24 Apr 21 | r27        | TBV LemgoTBV Lemgo | 28 - 34 | Rhein-Neckar LöwenRhein-Neckar |
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| 06 May 21 | r28        | Rhein-Neckar LöwenRhein-Neckar | 24 - 27 | Füchse BerlinFüchse Berlin |
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| 09 May 21 | r29        | TVB 1898 StuttgartTVB 1898 Stut | 32 - 28 | Rhein-Neckar LöwenRhein-Neckar |
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| 15 May 21 | r30        | Rhein-Neckar LöwenRhein-Neckar | 26 - 30 | HC ErlangenHC Erlangen |
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| 27 May 21 | r31        | SG Flensburg-HandewittSG Flensburg- | 26 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 02 Jun 21 | r33        | HBW Balingen-WeilstettenHBW Balingen- | 32 - 30 | Rhein-Neckar LöwenRhein-Neckar |
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| 13 Jun 21 | r34        | Rhein-Neckar LöwenRhein-Neckar | 31 - 22 | MT MelsungenMT Melsungen |
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| 16 Jun 21 | r35        | Bergischer HCBergischer HC | 26 - 28 | Rhein-Neckar LöwenRhein-Neckar |
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| 19 Jun 21 | r36        | Rhein-Neckar LöwenRhein-Neckar | 22 - 27 | SC MagdeburgSC Magdeburg |
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| 24 Jun 21 | r37        | TUSEM EssenTUSEM Essen | 23 - 33 | Rhein-Neckar LöwenRhein-Neckar |
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| 27 Jun 21 | r38        | Rhein-Neckar LöwenRhein-Neckar | 25 - 25 | THW KielTHW Kiel |