| 04 Sep 05 | r01        | Rhein-Neckar LöwenRhein-Neckar | 30 - 27 | TV GrosswallstadtTV Grosswalls |
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| 07 Sep 05 | r02        | Wilhelmshavener HVWilhelmshaven | 26 - 28 | Rhein-Neckar LöwenRhein-Neckar |
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| 10 Sep 05 | r03        | Rhein-Neckar LöwenRhein-Neckar | 27 - 22 | Handball PfullingenHandball Pful |
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| 17 Sep 05 | r04        | HSG Nordhorn-LingenHSG Nordhorn- | 30 - 24 | Rhein-Neckar LöwenRhein-Neckar |
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| 21 Sep 05 | r06        | SC MagdeburgSC Magdeburg | 25 - 22 | Rhein-Neckar LöwenRhein-Neckar |
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| 24 Sep 05 | r05        | Rhein-Neckar LöwenRhein-Neckar | 30 - 28 | Handball Sport Verein HamHandball Spor |
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| 08 Oct 05 | r07        | Rhein-Neckar LöwenRhein-Neckar | 28 - 28 | VfL GummersbachVfL Gummersba |
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| 12 Oct 05 | r08        | THW KielTHW Kiel | 30 - 19 | Rhein-Neckar LöwenRhein-Neckar |
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| 19 Oct 05 | r31        | Rhein-Neckar LöwenRhein-Neckar | 26 - 31 | TBV LemgoTBV Lemgo |
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| 22 Oct 05 | r09        | Rhein-Neckar LöwenRhein-Neckar | 30 - 27 | GWD MindenGWD Minden |
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| 06 Nov 05 | r10        | HSG WetzlarHSG Wetzlar | 26 - 28 | Rhein-Neckar LöwenRhein-Neckar |
| 16 Nov 05 | r10        | Rhein-Neckar LöwenRhein-Neckar | 26 - 27 | TPSG Frisch Auf GöppingenTPSG Frisch A |
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| 20 Nov 05 | r12        | HSG DüsseldorfHSG Düsseldor | 29 - 30 | Rhein-Neckar LöwenRhein-Neckar |
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| 07 Dec 05 | r13        | Rhein-Neckar LöwenRhein-Neckar | 37 - 30 | MT MelsungenMT Melsungen |
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| 18 Dec 05 | r15        | SG Flensburg-HandewittSG Flensburg- | 43 - 40 | Rhein-Neckar LöwenRhein-Neckar |
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| 21 Dec 05 | r16        | Rhein-Neckar LöwenRhein-Neckar | 28 - 20 | SV Concordia DelitzschSV Concordia |
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| 26 Dec 05 | r17        | TuS Nettelstedt-LübbeckeTuS Nettelste | 38 - 38 | Rhein-Neckar LöwenRhein-Neckar |
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| 29 Dec 05 | r18        | TV GrosswallstadtTV Grosswalls | 27 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 18 Feb 06 | r20        | Handball PfullingenHandball Pful | 22 - 25 | Rhein-Neckar LöwenRhein-Neckar |
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| 22 Feb 06 | r21        | Rhein-Neckar LöwenRhein-Neckar | 30 - 28 | HSG Nordhorn-LingenHSG Nordhorn- |
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| 01 Mar 06 | r19        | Rhein-Neckar LöwenRhein-Neckar | 26 - 18 | Wilhelmshavener HVWilhelmshaven |
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| 05 Mar 06 | r20        | Handball Sport Verein HamHandball Spor | 27 - 25 | Rhein-Neckar LöwenRhein-Neckar |
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| 12 Mar 06 | r23        | Rhein-Neckar LöwenRhein-Neckar | 33 - 32 | SC MagdeburgSC Magdeburg |
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| 18 Mar 06 | r24        | VfL GummersbachVfL Gummersba | 27 - 26 | Rhein-Neckar LöwenRhein-Neckar |
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| 22 Mar 06 | r25        | Rhein-Neckar LöwenRhein-Neckar | 31 - 34 | THW KielTHW Kiel |
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| 02 Apr 06 | r26        | GWD MindenGWD Minden | 28 - 27 | Rhein-Neckar LöwenRhein-Neckar |
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| 23 Apr 06 | r27        | Rhein-Neckar LöwenRhein-Neckar | 28 - 25 | HSG WetzlarHSG Wetzlar |
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| 02 May 06 | r28        | TPSG Frisch Auf GöppingenTPSG Frisch A | 29 - 28 | Rhein-Neckar LöwenRhein-Neckar |
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| 10 May 06 | r30        | MT MelsungenMT Melsungen | 31 - 28 | Rhein-Neckar LöwenRhein-Neckar |
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| 13 May 06 | r14        | TBV LemgoTBV Lemgo | 32 - 25 | Rhein-Neckar LöwenRhein-Neckar |
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| 17 May 06 | r29        | Rhein-Neckar LöwenRhein-Neckar | 34 - 24 | HSG DüsseldorfHSG Düsseldor |
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| 23 May 06 | r32        | Rhein-Neckar LöwenRhein-Neckar | 26 - 24 | SG Flensburg-HandewittSG Flensburg- |
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| 27 May 06 | r30        | SV Concordia DelitzschSV Concordia | 31 - 38 | Rhein-Neckar LöwenRhein-Neckar |
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| 03 Jun 06 | r34        | Rhein-Neckar LöwenRhein-Neckar | 36 - 25 | TuS Nettelstedt-LübbeckeTuS Nettelste |