| 16 Aug 80 | r00  | BirminghamBirmingham | 3 - 1 | CoventryCoventry |
| 16 Aug 80 | r00 | BrightonBrighton | 2 - 0 | WolvesWolves |
| 16 Aug 80 | r00 | LeedsLeeds | 1 - 2 | Aston VillaAston Villa |
| 16 Aug 80 | r00 | LeicesterLeicester | 0 - 1 | IpswichIpswich |
| 16 Aug 80 | r00 | LiverpoolLiverpool | 3 - 0 | Crystal PalaceCrystal Palac |
| 16 Aug 80 | r00 | Manchester UnitedManchester Un | 3 - 0 | MiddlesbroughMiddlesbrough |
| 16 Aug 80 | r00 | NorwichNorwich | 5 - 1 | StokeStoke |
| 16 Aug 80 | r00 | SouthamptonSouthampton | 2 - 0 | Manchester CityManchester Ci |
| 16 Aug 80 | r00 | SunderlandSunderland | 3 - 1 | EvertonEverton |
| 16 Aug 80 | r00 | TottenhamTottenham | 2 - 0 | Nottingham F.Nottingham F. |
| 16 Aug 80 | r00 | West BromWest Brom | 0 - 1 | ArsenalArsenal |
| 19 Aug 80 | r00 | ArsenalArsenal | 1 - 1 | SouthamptonSouthampton |
| 19 Aug 80 | r00 | CoventryCoventry | 0 - 0 | LiverpoolLiverpool |
| 19 Aug 80 | r00 | Crystal PalaceCrystal Palac | 3 - 4 | TottenhamTottenham |
| 19 Aug 80 | r00 | EvertonEverton | 1 - 0 | LeicesterLeicester |
| 19 Aug 80 | r00 | IpswichIpswich | 2 - 0 | BrightonBrighton |
| 19 Aug 80 | r00 | MiddlesbroughMiddlesbrough | 3 - 0 | LeedsLeeds |
| 19 Aug 80 | r00 | WolvesWolves | 1 - 0 | Manchester UnitedManchester Un |
| 20 Aug 80 | r00 | Aston VillaAston Villa | 1 - 0 | NorwichNorwich |
| 20 Aug 80 | r00 | Manchester CityManchester Ci | 0 - 4 | SunderlandSunderland |
| 20 Aug 80 | r00 | Nottingham F.Nottingham F. | 2 - 1 | BirminghamBirmingham |
| 20 Aug 80 | r00 | StokeStoke | 0 - 0 | West BromWest Brom |
| 23 Aug 80 | r00 | BirminghamBirmingham | 0 - 0 | Manchester UnitedManchester Un |
| 23 Aug 80 | r00 | CoventryCoventry | 3 - 1 | ArsenalArsenal |
| 23 Aug 80 | r00 | Crystal PalaceCrystal Palac | 5 - 2 | MiddlesbroughMiddlesbrough |
| 23 Aug 80 | r00 | EvertonEverton | 0 - 0 | Nottingham F.Nottingham F. |
| 23 Aug 80 | r00 | LeicesterLeicester | 2 - 0 | LiverpoolLiverpool |
| 23 Aug 80 | r00 | Manchester CityManchester Ci | 2 - 2 | Aston VillaAston Villa |
| 23 Aug 80 | r00 | NorwichNorwich | 2 - 3 | LeedsLeeds |
| 23 Aug 80 | r00 | StokeStoke | 2 - 2 | IpswichIpswich |
| 23 Aug 80 | r00 | SunderlandSunderland | 1 - 2 | SouthamptonSouthampton |
| 23 Aug 80 | r00 | TottenhamTottenham | 2 - 2 | BrightonBrighton |
| 23 Aug 80 | r00 | West BromWest Brom | 1 - 1 | WolvesWolves |
| 30 Aug 80 | r00 | ArsenalArsenal | 2 - 0 | TottenhamTottenham |
| 30 Aug 80 | r00 | Aston VillaAston Villa | 1 - 0 | CoventryCoventry |
| 30 Aug 80 | r00 | BrightonBrighton | 1 - 2 | West BromWest Brom |
| 30 Aug 80 | r00 | IpswichIpswich | 4 - 0 | EvertonEverton |
| 30 Aug 80 | r00 | LeedsLeeds | 1 - 2 | LeicesterLeicester |
| 30 Aug 80 | r00 | LiverpoolLiverpool | 4 - 1 | NorwichNorwich |
| 30 Aug 80 | r00 | Manchester UnitedManchester Un | 1 - 1 | SunderlandSunderland |
| 30 Aug 80 | r00 | MiddlesbroughMiddlesbrough | 2 - 2 | Manchester CityManchester Ci |
| 30 Aug 80 | r00 | Nottingham F.Nottingham F. | 5 - 0 | StokeStoke |
| 30 Aug 80 | r00 | SouthamptonSouthampton | 3 - 1 | BirminghamBirmingham |
| 30 Aug 80 | r00 | WolvesWolves | 2 - 0 | Crystal PalaceCrystal Palac |
| 06 Sep 80 | r00 | BirminghamBirmingham | 1 - 1 | LiverpoolLiverpool |
| 06 Sep 80 | r00 | CoventryCoventry | 3 - 1 | Crystal PalaceCrystal Palac |
| 06 Sep 80 | r00 | EvertonEverton | 2 - 0 | WolvesWolves |
| 06 Sep 80 | r00 | IpswichIpswich | 1 - 0 | Aston VillaAston Villa |
| 06 Sep 80 | r00 | LeicesterLeicester | 0 - 1 | SunderlandSunderland |
| 06 Sep 80 | r00 | Manchester CityManchester Ci | 1 - 1 | ArsenalArsenal |
| 06 Sep 80 | r00 | MiddlesbroughMiddlesbrough | 0 - 0 | Nottingham F.Nottingham F. |
| 06 Sep 80 | r00 | SouthamptonSouthampton | 3 - 1 | BrightonBrighton |
| 06 Sep 80 | r00 | StokeStoke | 3 - 0 | LeedsLeeds |
| 06 Sep 80 | r00 | TottenhamTottenham | 0 - 0 | Manchester UnitedManchester Un |
| 06 Sep 80 | r00 | West BromWest Brom | 3 - 0 | NorwichNorwich |
| 13 Sep 80 | r00 | ArsenalArsenal | 2 - 0 | StokeStoke |
| 13 Sep 80 | r00 | Aston VillaAston Villa | 0 - 2 | EvertonEverton |
| 13 Sep 80 | r00 | BrightonBrighton | 2 - 2 | BirminghamBirmingham |
| 13 Sep 80 | r00 | Crystal PalaceCrystal Palac | 1 - 2 | IpswichIpswich |
| 13 Sep 80 | r00 | LeedsLeeds | 0 - 0 | TottenhamTottenham |
| 13 Sep 80 | r00 | LiverpoolLiverpool | 4 - 0 | West BromWest Brom |
| 13 Sep 80 | r00 | Manchester UnitedManchester Un | 5 - 0 | LeicesterLeicester |
| 13 Sep 80 | r00 | NorwichNorwich | 1 - 0 | SouthamptonSouthampton |
| 13 Sep 80 | r00 | Nottingham F.Nottingham F. | 3 - 2 | Manchester CityManchester Ci |
| 13 Sep 80 | r00 | SunderlandSunderland | 0 - 1 | MiddlesbroughMiddlesbrough |
| 13 Sep 80 | r00 | WolvesWolves | 0 - 1 | CoventryCoventry |
| 20 Sep 80 | r00 | Aston VillaAston Villa | 2 - 1 | WolvesWolves |
| 20 Sep 80 | r00 | BirminghamBirmingham | 1 - 1 | West BromWest Brom |
| 20 Sep 80 | r00 | BrightonBrighton | 2 - 0 | NorwichNorwich |
| 20 Sep 80 | r00 | EvertonEverton | 5 - 0 | Crystal PalaceCrystal Palac |
| 20 Sep 80 | r00 | IpswichIpswich | 2 - 0 | CoventryCoventry |
| 20 Sep 80 | r00 | LeedsLeeds | 0 - 0 | Manchester UnitedManchester Un |
| 20 Sep 80 | r00 | Manchester CityManchester Ci | 1 - 2 | StokeStoke |
| 20 Sep 80 | r00 | MiddlesbroughMiddlesbrough | 2 - 1 | ArsenalArsenal |
| 20 Sep 80 | r00 | Nottingham F.Nottingham F. | 5 - 0 | LeicesterLeicester |
| 20 Sep 80 | r00 | SouthamptonSouthampton | 2 - 2 | LiverpoolLiverpool |
| 20 Sep 80 | r00 | TottenhamTottenham | 0 - 0 | SunderlandSunderland |
| 27 Sep 80 | r00 | ArsenalArsenal | 1 - 0 | Nottingham F.Nottingham F. |
| 27 Sep 80 | r00 | CoventryCoventry | 0 - 5 | EvertonEverton |
| 27 Sep 80 | r00 | Crystal PalaceCrystal Palac | 0 - 1 | Aston VillaAston Villa |
| 27 Sep 80 | r00 | LeicesterLeicester | 2 - 1 | TottenhamTottenham |
| 27 Sep 80 | r00 | LiverpoolLiverpool | 4 - 1 | BrightonBrighton |
| 27 Sep 80 | r00 | Manchester UnitedManchester Un | 2 - 2 | Manchester CityManchester Ci |
| 27 Sep 80 | r00 | NorwichNorwich | 2 - 2 | BirminghamBirmingham |
| 27 Sep 80 | r00 | StokeStoke | 1 - 0 | MiddlesbroughMiddlesbrough |
| 27 Sep 80 | r00 | SunderlandSunderland | 4 - 1 | LeedsLeeds |
| 27 Sep 80 | r00 | West BromWest Brom | 2 - 1 | SouthamptonSouthampton |
| 27 Sep 80 | r00 | WolvesWolves | 0 - 2 | IpswichIpswich |
| 04 Oct 80 | r00 | ArsenalArsenal | 1 - 0 | LeicesterLeicester |
| 04 Oct 80 | r00 | Aston VillaAston Villa | 4 - 0 | SunderlandSunderland |
| 04 Oct 80 | r00 | CoventryCoventry | 3 - 3 | BrightonBrighton |
| 04 Oct 80 | r00 | Crystal PalaceCrystal Palac | 0 - 1 | West BromWest Brom |
| 04 Oct 80 | r00 | EvertonEverton | 2 - 1 | SouthamptonSouthampton |
| 04 Oct 80 | r00 | IpswichIpswich | 1 - 1 | LeedsLeeds |
| 04 Oct 80 | r00 | Manchester CityManchester Ci | 0 - 3 | LiverpoolLiverpool |
| 04 Oct 80 | r00 | MiddlesbroughMiddlesbrough | 6 - 1 | NorwichNorwich |
| 04 Oct 80 | r00 | Nottingham F.Nottingham F. | 1 - 2 | Manchester UnitedManchester Un |
| 04 Oct 80 | r00 | StokeStoke | 2 - 3 | TottenhamTottenham |
| 04 Oct 80 | r00 | WolvesWolves | 1 - 0 | BirminghamBirmingham |
| 07 Oct 80 | r00 | BirminghamBirmingham | 3 - 1 | ArsenalArsenal |
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