| 27 May 25 | r06     | São PauloSão Paulo | 2 - 1 | Talleres de CórdobaTalleres de C |
| 27 May 25 | r06  | Club LibertadClub Libertad | 2 - 2 | Alianza LimaAlianza Lima |
| 28 May 25 | r06 | BotafogoBotafogo | 1 - 0 | Universidad de ChileUniversidad d |
| 28 May 25 | r06 | Estudiantes de La PlataEstudiantes d | 2 - 0 | CaraboboCarabobo |
| 28 May 25 | r06 | River PlateRiver Plate | 1 - 1 | UniversitarioUniversitario |
| 28 May 25 | r06 | Independiente del ValleIndependiente | 2 - 1 | Barcelona SCBarcelona SC |
| 28 May 25 | r06 | Nacional MontevideoNacional Mont | 1 - 0 | Atlético NacionalAtlético Naci |
| 28 May 25 | r06 | InternacionalInternacional | 2 - 1 | BahiaBahia |
| 29 May 25 | r06 | FlamengoFlamengo | 1 - 0 | Deportivo TáchiraDeportivo Tác |
| 29 May 25 | r06 | LDU QuitoLDU Quito | 3 - 0 | Central Córdoba de SantiaCentral Córdo |
| 29 May 25 | r06 | PalmeirasPalmeiras | 6 - 0 | Sporting CristalSporting Cris |
| 29 May 25 | r06 | BolívarBolívar | 4 - 0 | Cerro PorteñoCerro Porteño |
| 29 May 25 | r06 | PeñarolPeñarol | 0 - 0 | Vélez SarsfieldVélez Sarsfie |
| 29 May 25 | r06 | Club OlimpiaClub Olimpia | 4 - 0 | San Antonio Bulo BuloSan Antonio B |
| 30 May 25 | r06 | Racing ClubRacing Club | 1 - 0 | FortalezaFortaleza |
| 30 May 25 | r06 | Colo-ColoColo-Colo | 1 - 0 | Atlético BucaramangaAtlético Buca |
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