| 13 May 25 | r05     | Deportivo TáchiraDeportivo Tác | 1 - 2 | Central Córdoba de SantiaCentral Córdo |
| 14 May 25 | r05 | Universidad de ChileUniversidad d | 4 - 0 | CaraboboCarabobo |
| 14 May 25 | r05 | FortalezaFortaleza | 0 - 0 | Atlético BucaramangaAtlético Buca |
| 14 May 25 | r05 | Sporting CristalSporting Cris | 0 - 1 | Cerro PorteñoCerro Porteño |
| 14 May 25 | r05 | Atlético NacionalAtlético Naci | 1 - 0 | BahiaBahia |
| 14 May 25 | r05 | PeñarolPeñarol | 3 - 2 | Club OlimpiaClub Olimpia |
| 14 May 25 | r05 | Vélez SarsfieldVélez Sarsfie | 3 - 0 | San Antonio Bulo BuloSan Antonio B |
| 15 May 25 | r05 | BotafogoBotafogo | 3 - 2 | Estudiantes de La PlataEstudiantes d |
| 15 May 25 | r05 | São PauloSão Paulo | 1 - 1 | Club LibertadClub Libertad |
| 15 May 25 | r05 | Racing ClubRacing Club | 4 - 0 | Colo-ColoColo-Colo |
| 15 May 25 | r05 | UniversitarioUniversitario | 1 - 0 | Barcelona SCBarcelona SC |
| 15 May 25 | r05  | Talleres de CórdobaTalleres de C | 2 - 0 | Alianza LimaAlianza Lima |
| 15 May 25 | r05 | Nacional MontevideoNacional Mont | 0 - 2 | InternacionalInternacional |
| 15 May 25 | r05 | PalmeirasPalmeiras | 2 - 0 | BolívarBolívar |
| 16 May 25 | r05 | River PlateRiver Plate | 6 - 2 | Independiente del ValleIndependiente |
| 16 May 25 | r05 | FlamengoFlamengo | 2 - 0 | LDU QuitoLDU Quito |
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