| 06 May 25 | r04     | CaraboboCarabobo | 1 - 2 | BotafogoBotafogo |
| 06 May 25 | r04 | Alianza LimaAlianza Lima | 0 - 2 | São PauloSão Paulo |
| 06 May 25 | r04 | Atlético BucaramangaAtlético Buca | 0 - 4 | Racing ClubRacing Club |
| 07 May 25 | r04 | FortalezaFortaleza | 4 - 0 | Colo-ColoColo-Colo |
| 07 May 25 | r04 | San Antonio Bulo BuloSan Antonio B | 0 - 3 | PeñarolPeñarol |
| 07 May 25 | r04 | Deportivo TáchiraDeportivo Tác | 2 - 3 | LDU QuitoLDU Quito |
| 07 May 25 | r04 | BahiaBahia | 1 - 3 | Nacional MontevideoNacional Mont |
| 08 May 25 | r04 | Universidad de ChileUniversidad d | 0 - 3 | Estudiantes de La PlataEstudiantes d |
| 08 May 25 | r04 | Central Córdoba de SantiaCentral Córdo | 1 - 1 | FlamengoFlamengo |
| 08 May 25 | r04 | Cerro PorteñoCerro Porteño | 0 - 2 | PalmeirasPalmeiras |
| 08 May 25 | r04 | Sporting CristalSporting Cris | 2 - 1 | BolívarBolívar |
| 08 May 25 | r04 | Talleres de CórdobaTalleres de C | 0 - 0 | Club LibertadClub Libertad |
| 08 May 25 | r04 | Vélez SarsfieldVélez Sarsfie | 1 - 1 | Club OlimpiaClub Olimpia |
| 09 May 25 | r04 | Barcelona SCBarcelona SC | 2 - 3 | River PlateRiver Plate |
| 09 May 25 | r04 | Atlético NacionalAtlético Naci | 3 - 1 | InternacionalInternacional |
| 09 May 25 | r04 | UniversitarioUniversitario | 1 - 1 | Independiente del ValleIndependiente |
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