| 23 May 23 | r04     | Monagas S.C.Monagas S.C. | 1 - 1 | Colo-ColoColo-Colo |
| 23 May 23 | r04  | Atletico MGAtletico MG | 2 - 1 | Atletico PRAtletico PR |
| 24 May 23 | r04 | SD AucasSD Aucas | 1 - 2 | Racing ClubRacing Club |
| 24 May 23 | r04 | BolivarBolivar | 1 - 0 | Barcelona SCBarcelona SC |
| 24 May 23 | r04 | Independiente MedellínIndependiente | 2 - 1 | Nacional MontevideoNacional Mont |
| 24 May 23 | r04 | Alianza LimaAlianza Lima | 1 - 2 | Club LibertadClub Libertad |
| 24 May 23 | r04 | Liverpool MontevideoLiverpool Mon | 1 - 0 | Independiente del ValleIndependiente |
| 24 May 23 | r04 | Cerro PorteñoCerro Porteño | 0 - 3 | PalmeirasPalmeiras |
| 25 May 23 | r04 | Deportivo PereiraDeportivo Per | 1 - 0 | Boca JuniorsBoca Juniors |
| 25 May 23 | r04 | Argentinos JuniorsArgentinos Ju | 0 - 0 | CorinthiansCorinthians |
| 25 May 23 | r04 | ÑublenseÑublense | 1 - 1 | FlamengoFlamengo |
| 25 May 23 | r04 | FBC MelgarFBC Melgar | 0 - 1 | Atlético NacionalAtlético Naci |
| 25 May 23 | r04 | Patronato de ParanaPatronato de | 0 - 2 | Club OlimpiaClub Olimpia |
| 25 May 23 | r04 | The StrongestThe Strongest | 1 - 0 | FluminenseFluminense |
| 26 May 23 | r04 | Metropolitanos F.C.Metropolitano | 1 - 2 | InternacionalInternacional |
| 26 May 23 | r04 | Sporting CristalSporting Cris | 1 - 1 | River PlateRiver Plate |
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