| 24 May 22 | r06     | Nacional MontevideoNacional Mont | 3 - 0 | BragantinoBragantino |
| 24 May 22 | r06 | Velez SarsfieldVelez Sarsfie | 4 - 0 | Estudiantes de la PlataEstudiantes d |
| 25 May 22 | r06 | PalmeirasPalmeiras | 4 - 1 | Deportivo Táchira F.C.Deportivo Tác |
| 25 May 22 | r06 | EmelecEmelec | 7 - 0 | Independiente PetroleroIndependiente |
| 25 May 22 | r06 | FlamengoFlamengo | 2 - 1 | Sporting CristalSporting Cris |
| 25 May 22 | r06 | Universidad CatólicaUniversidad C | 0 - 1 | Talleres de CordobaTalleres de C |
| 25 May 22 | r06  | River PlateRiver Plate | 8 - 1 | Alianza LimaAlianza Lima |
| 25 May 22 | r06 | Colo-ColoColo-Colo | 3 - 4 | FortalezaFortaleza |
| 26 May 22 | r06 | Atletico MGAtletico MG | 1 - 2 | Deportes TolimaDeportes Toli |
| 26 May 22 | r06 | Independiente del ValleIndependiente | 3 - 0 | America MGAmerica MG |
| 26 May 22 | r06 | PeñarolPeñarol | 2 - 1 | ColonColon |
| 26 May 22 | r06 | Cerro PorteñoCerro Porteño | 0 - 1 | Club OlimpiaClub Olimpia |
| 26 May 22 | r06 | Atletico PRAtletico PR | 5 - 1 | Caracas F.C.Caracas F.C. |
| 26 May 22 | r06 | Club LibertadClub Libertad | 4 - 1 | The StrongestThe Strongest |
| 27 May 22 | r06 | Boca JuniorsBoca Juniors | 1 - 0 | Deportivo CaliDeportivo Cal |
| 27 May 22 | r06 | CorinthiansCorinthians | 1 - 1 | Always ReadyAlways Ready |
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