| 04 May 21 | r03     | Santos FCSantos FC | 5 - 0 | The StrongestThe Strongest |
| 04 May 21 | r03 | Unión La CaleraUnión La Cale | 0 - 2 | Velez SarsfieldVelez Sarsfie |
| 04 May 21 | r03 | Atletico MGAtletico MG | 4 - 0 | Cerro PorteñoCerro Porteño |
| 05 May 21 | r03 | Defensa y JusticiaDefensa y Jus | 1 - 2 | PalmeirasPalmeiras |
| 05 May 21 | r03 | Barcelona SCBarcelona SC | 1 - 0 | Boca JuniorsBoca Juniors |
| 05 May 21 | r03 | LDU QuitoLDU Quito | 2 - 3 | FlamengoFlamengo |
| 05 May 21 | r03 | Independiente del ValleIndependiente | 4 - 0 | UniversitarioUniversitario |
| 05 May 21 | r03 | Racing ClubRacing Club | 0 - 0 | Sao PauloSao Paulo |
| 06 May 21 | r03 | InternacionalInternacional | 6 - 1 | Club OlimpiaClub Olimpia |
| 06 May 21 | r03 | RentistasRentistas | 0 - 0 | Sporting CristalSporting Cris |
| 06 May 21 | r03 | Always ReadyAlways Ready | 2 - 0 | Deportivo Táchira F.C.Deportivo Tác |
| 06 May 21 | r03 | Universidad CatólicaUniversidad C | 3 - 1 | Nacional MontevideoNacional Mont |
| 06 May 21 | r03 | Atlético NacionalAtlético Naci | 0 - 2 | Argentinos JuniorsArgentinos Ju |
| 07 May 21 | r03 | Atlético JuniorAtlético Juni | 1 - 1 | FluminenseFluminense |
| 07 May 21 | r03 | Independiente Santa FeIndependiente | 0 - 0 | River PlateRiver Plate |
| 07 May 21 | r03 | Real Esppor ClubReal Esppor C | 0 - 0 | América de CaliAmérica de Ca |
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