| 27 Apr 21 | r02     | LDU QuitoLDU Quito | 3 - 1 | Velez SarsfieldVelez Sarsfie |
| 27 Apr 21 | r02 | FlamengoFlamengo | 4 - 1 | Unión La CaleraUnión La Cale |
| 27 Apr 21 | r02  | Atletico MGAtletico MG | 2 - 1 | América de CaliAmérica de Ca |
| 28 Apr 21 | r02 | PalmeirasPalmeiras | 5 - 0 | Independiente del ValleIndependiente |
| 28 Apr 21 | r02 | InternacionalInternacional | 4 - 0 | Deportivo Táchira F.C.Deportivo Tác |
| 28 Apr 21 | r02 | Boca JuniorsBoca Juniors | 2 - 0 | Santos FCSantos FC |
| 28 Apr 21 | r02 | Defensa y JusticiaDefensa y Jus | 3 - 0 | UniversitarioUniversitario |
| 28 Apr 21 | r02 | Nacional MontevideoNacional Mont | 4 - 4 | Atlético NacionalAtlético Naci |
| 28 Apr 21 | r02 | Cerro PorteñoCerro Porteño | 0 - 0 | Real Esppor ClubReal Esppor C |
| 29 Apr 21 | r02 | Independiente Santa FeIndependiente | 1 - 2 | FluminenseFluminense |
| 29 Apr 21 | r02 | River PlateRiver Plate | 2 - 1 | Atlético JuniorAtlético Juni |
| 29 Apr 21 | r02 | Club OlimpiaClub Olimpia | 2 - 1 | Always ReadyAlways Ready |
| 29 Apr 21 | r02 | Barcelona SCBarcelona SC | 4 - 0 | The StrongestThe Strongest |
| 29 Apr 21 | r02 | Racing ClubRacing Club | 2 - 1 | Sporting CristalSporting Cris |
| 29 Apr 21 | r02 | Universidad CatólicaUniversidad C | 0 - 2 | Argentinos JuniorsArgentinos Ju |
| 30 Apr 21 | r02 | Sao PauloSao Paulo | 2 - 0 | RentistasRentistas |
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