| 11 May 21 | r04     | Deportivo Táchira F.C.Deportivo Tác | 2 - 1 | InternacionalInternacional |
| 11 May 21 | r04 | The StrongestThe Strongest | 2 - 0 | Barcelona SCBarcelona SC |
| 11 May 21 | r04 | Santos FCSantos FC | 1 - 0 | Boca JuniorsBoca Juniors |
| 12 May 21 | r04 | Unión La CaleraUnión La Cale | 2 - 2 | FlamengoFlamengo |
| 12 May 21 | r04 | Independiente del ValleIndependiente | 0 - 1 | PalmeirasPalmeiras |
| 12 May 21 | r04 | Sporting CristalSporting Cris | 0 - 2 | Racing ClubRacing Club |
| 12 May 21 | r04 | RentistasRentistas | 1 - 1 | Sao PauloSao Paulo |
| 12 May 21 | r04 | Argentinos JuniorsArgentinos Ju | 0 - 1 | Universidad CatólicaUniversidad C |
| 13 May 21 | r04 | FluminenseFluminense | 2 - 1 | Independiente Santa FeIndependiente |
| 13 May 21 | r04 | Atlético JuniorAtlético Juni | 1 - 1 | River PlateRiver Plate |
| 13 May 21 | r04 | Real Esppor ClubReal Esppor C | 0 - 1 | Cerro PorteñoCerro Porteño |
| 13 May 21 | r04 | UniversitarioUniversitario | 1 - 1 | Defensa y JusticiaDefensa y Jus |
| 13 May 21 | r04 | Atlético NacionalAtlético Naci | 0 - 0 | Nacional MontevideoNacional Mont |
| 13 May 21 | r04 | Velez SarsfieldVelez Sarsfie | 3 - 1 | LDU QuitoLDU Quito |
| 14 May 21 | r04 | Always ReadyAlways Ready | 1 - 2 | Club OlimpiaClub Olimpia |
| 14 May 21 | r04  | América de CaliAmérica de Ca | 1 - 3 | Atletico MGAtletico MG |
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