| 24 Feb 21 | Qualifier     | Liverpool MontevideoLiverpool Mon | 2 - 1 | Universidad Católica del Universidad C |
| 24 Feb 21 | Qualifier | Universidad César VallejoUniversidad C | 0 - 0 | Caracas F.C.Caracas F.C. |
| 25 Feb 21 | Qualifier | Royal PariRoyal Pari | 1 - 4 | Club GuaraníClub Guaraní |
| 03 Mar 21 | Qualifier | Universidad Católica del Universidad C | 3 - 0 | Liverpool MontevideoLiverpool Mon |
| 03 Mar 21 | Qualifier | Caracas F.C.Caracas F.C. | 2 - 0 | Universidad César VallejoUniversidad C |
| 04 Mar 21 | Qualifier | Club GuaraníClub Guaraní | 1 - 1 | Royal PariRoyal Pari |
| 09 Mar 21 | Qualifier | Santos FCSantos FC | 2 - 1 | Deportivo LaraDeportivo Lar |
| 09 Mar 21 | Qualifier | WanderersWanderers | 1 - 0 | BolivarBolivar |
| 10 Mar 21 | Qualifier | Unión EspañolaUnión Español | 1 - 0 | Independiente del ValleIndependiente |
| 10 Mar 21 | Qualifier | Universidad Católica del Universidad C | 0 - 1 | Club LibertadClub Libertad |
| 11 Mar 21 | Qualifier | Universidad de ChileUniversidad d | 1 - 1 | San LorenzoSan Lorenzo |
| 11 Mar 21 | Qualifier | Caracas F.C.Caracas F.C. | 1 - 2 | Atlético JuniorAtlético Juni |
| 11 Mar 21 | Qualifier | GremioGremio | 6 - 1 | Ayacucho FCAyacucho FC |
| 12 Mar 21 | Qualifier | Club GuaraníClub Guaraní | 0 - 2 | Atlético NacionalAtlético Naci |
| 16 Mar 21 | Qualifier | Deportivo LaraDeportivo Lar | 1 - 1 | Santos FCSantos FC |
| 16 Mar 21 | Qualifier | BolivarBolivar | 5 - 0 | WanderersWanderers |
| 17 Mar 21 | Qualifier | Independiente del ValleIndependiente | 6 - 2 | Unión EspañolaUnión Español |
| 17 Mar 21 | Qualifier | Ayacucho FCAyacucho FC | 1 - 2 | GremioGremio |
| 17 Mar 21 | Qualifier | Club LibertadClub Libertad | 2 - 2 | Universidad Católica del Universidad C |
| 18 Mar 21 | Qualifier | San LorenzoSan Lorenzo | 2 - 0 | Universidad de ChileUniversidad d |
| 18 Mar 21 | Qualifier | Atlético JuniorAtlético Juni | 3 - 1 | Caracas F.C.Caracas F.C. |
| 19 Mar 21 | Qualifier  | Atlético NacionalAtlético Naci | 3 - 0 | Club GuaraníClub Guaraní |
| 07 Apr 21 | Qualifier  | San LorenzoSan Lorenzo | 1 - 3 | Santos FCSantos FC |
| 08 Apr 21 | Qualifier | Club LibertadClub Libertad | 1 - 0 | Atlético NacionalAtlético Naci |
| 09 Apr 21 | Qualifier | BolivarBolivar | 2 - 1 | Atlético JuniorAtlético Juni |
| 09 Apr 21 | Qualifier | Independiente del ValleIndependiente | 2 - 1 | GremioGremio |
| 14 Apr 21 | Qualifier | Santos FCSantos FC | 2 - 2 | San LorenzoSan Lorenzo |
| 14 Apr 21 | Qualifier | GremioGremio | 1 - 2 | Independiente del ValleIndependiente |
| 15 Apr 21 | Qualifier | Atlético NacionalAtlético Naci | 4 - 1 | Club LibertadClub Libertad |
| 16 Apr 21 | Qualifier | Atlético JuniorAtlético Juni | 3 - 0 | BolivarBolivar |
| |
| 20 Apr 21 | r01 | Always ReadyAlways Ready | 2 - 0 | InternacionalInternacional |
| 20 Apr 21 | r01 | Deportivo Táchira F.C.Deportivo Tác | 3 - 2 | Club OlimpiaClub Olimpia |
| 20 Apr 21 | r01 | Santos FCSantos FC | 0 - 2 | Barcelona SCBarcelona SC |
| 20 Apr 21 | r01 | Argentinos JuniorsArgentinos Ju | 2 - 0 | Nacional MontevideoNacional Mont |
| 21 Apr 21 | r01 | Sporting CristalSporting Cris | 0 - 3 | Sao PauloSao Paulo |
| 21 Apr 21 | r01 | Velez SarsfieldVelez Sarsfie | 2 - 3 | FlamengoFlamengo |
| 21 Apr 21 | r01 | The StrongestThe Strongest | 0 - 1 | Boca JuniorsBoca Juniors |
| 21 Apr 21 | r01 | Real Esppor ClubReal Esppor C | 1 - 1 | Atletico MGAtletico MG |
| 22 Apr 21 | r01 | Independiente del ValleIndependiente | 1 - 1 | Defensa y JusticiaDefensa y Jus |
| 22 Apr 21 | r01 | UniversitarioUniversitario | 2 - 3 | PalmeirasPalmeiras |
| 22 Apr 21 | r01 | RentistasRentistas | 1 - 1 | Racing ClubRacing Club |
| 22 Apr 21 | r01 | Unión La CaleraUnión La Cale | 2 - 2 | LDU QuitoLDU Quito |
| 22 Apr 21 | r01 | América de CaliAmérica de Ca | 0 - 2 | Cerro PorteñoCerro Porteño |
| 22 Apr 21 | r01 | FluminenseFluminense | 1 - 1 | River PlateRiver Plate |
| 23 Apr 21 | r01 | Atlético NacionalAtlético Naci | 2 - 0 | Universidad CatólicaUniversidad C |
| 23 Apr 21 | r01 | Atlético JuniorAtlético Juni | 1 - 1 | Independiente Santa FeIndependiente |
| |
| 27 Apr 21 | r02 | LDU QuitoLDU Quito | 3 - 1 | Velez SarsfieldVelez Sarsfie |
| 27 Apr 21 | r02 | FlamengoFlamengo | 4 - 1 | Unión La CaleraUnión La Cale |
| 27 Apr 21 | r02 | Atletico MGAtletico MG | 2 - 1 | América de CaliAmérica de Ca |
| 28 Apr 21 | r02 | PalmeirasPalmeiras | 5 - 0 | Independiente del ValleIndependiente |
| 28 Apr 21 | r02 | InternacionalInternacional | 4 - 0 | Deportivo Táchira F.C.Deportivo Tác |
| 28 Apr 21 | r02 | Boca JuniorsBoca Juniors | 2 - 0 | Santos FCSantos FC |
| 28 Apr 21 | r02 | Defensa y JusticiaDefensa y Jus | 3 - 0 | UniversitarioUniversitario |
| 28 Apr 21 | r02 | Nacional MontevideoNacional Mont | 4 - 4 | Atlético NacionalAtlético Naci |
| 28 Apr 21 | r02 | Cerro PorteñoCerro Porteño | 0 - 0 | Real Esppor ClubReal Esppor C |
| 29 Apr 21 | r02 | Independiente Santa FeIndependiente | 1 - 2 | FluminenseFluminense |
| 29 Apr 21 | r02 | River PlateRiver Plate | 2 - 1 | Atlético JuniorAtlético Juni |
| 29 Apr 21 | r02 | Club OlimpiaClub Olimpia | 2 - 1 | Always ReadyAlways Ready |
| 29 Apr 21 | r02 | Barcelona SCBarcelona SC | 4 - 0 | The StrongestThe Strongest |
| 29 Apr 21 | r02 | Racing ClubRacing Club | 2 - 1 | Sporting CristalSporting Cris |
| 29 Apr 21 | r02 | Universidad CatólicaUniversidad C | 0 - 2 | Argentinos JuniorsArgentinos Ju |
| 30 Apr 21 | r02 | Sao PauloSao Paulo | 2 - 0 | RentistasRentistas |
| |
| 04 May 21 | r03 | Santos FCSantos FC | 5 - 0 | The StrongestThe Strongest |
| 04 May 21 | r03 | Unión La CaleraUnión La Cale | 0 - 2 | Velez SarsfieldVelez Sarsfie |
| 04 May 21 | r03 | Atletico MGAtletico MG | 4 - 0 | Cerro PorteñoCerro Porteño |
| 05 May 21 | r03 | Defensa y JusticiaDefensa y Jus | 1 - 2 | PalmeirasPalmeiras |
| 05 May 21 | r03 | Barcelona SCBarcelona SC | 1 - 0 | Boca JuniorsBoca Juniors |
| 05 May 21 | r03 | LDU QuitoLDU Quito | 2 - 3 | FlamengoFlamengo |
| 05 May 21 | r03 | Independiente del ValleIndependiente | 4 - 0 | UniversitarioUniversitario |
| 05 May 21 | r03 | Racing ClubRacing Club | 0 - 0 | Sao PauloSao Paulo |
| 06 May 21 | r03 | InternacionalInternacional | 6 - 1 | Club OlimpiaClub Olimpia |
| 06 May 21 | r03 | RentistasRentistas | 0 - 0 | Sporting CristalSporting Cris |
| 06 May 21 | r03 | Always ReadyAlways Ready | 2 - 0 | Deportivo Táchira F.C.Deportivo Tác |
| 06 May 21 | r03 | Universidad CatólicaUniversidad C | 3 - 1 | Nacional MontevideoNacional Mont |
| 06 May 21 | r03 | Atlético NacionalAtlético Naci | 0 - 2 | Argentinos JuniorsArgentinos Ju |
| 07 May 21 | r03 | Atlético JuniorAtlético Juni | 1 - 1 | FluminenseFluminense |
| 07 May 21 | r03 | Independiente Santa FeIndependiente | 0 - 0 | River PlateRiver Plate |
| 07 May 21 | r03 | Real Esppor ClubReal Esppor C | 0 - 0 | América de CaliAmérica de Ca |
| |
| 11 May 21 | r04 | Deportivo Táchira F.C.Deportivo Tác | 2 - 1 | InternacionalInternacional |
| 11 May 21 | r04 | The StrongestThe Strongest | 2 - 0 | Barcelona SCBarcelona SC |
| 11 May 21 | r04 | Santos FCSantos FC | 1 - 0 | Boca JuniorsBoca Juniors |
| 12 May 21 | r04 | Unión La CaleraUnión La Cale | 2 - 2 | FlamengoFlamengo |
| 12 May 21 | r04 | Independiente del ValleIndependiente | 0 - 1 | PalmeirasPalmeiras |
| 12 May 21 | r04 | Sporting CristalSporting Cris | 0 - 2 | Racing ClubRacing Club |
| 12 May 21 | r04 | RentistasRentistas | 1 - 1 | Sao PauloSao Paulo |
| 12 May 21 | r04 | Argentinos JuniorsArgentinos Ju | 0 - 1 | Universidad CatólicaUniversidad C |
| 13 May 21 | r04 | FluminenseFluminense | 2 - 1 | Independiente Santa FeIndependiente |
| 13 May 21 | r04 | Atlético JuniorAtlético Juni | 1 - 1 | River PlateRiver Plate |
| 13 May 21 | r04 | Real Esppor ClubReal Esppor C | 0 - 1 | Cerro PorteñoCerro Porteño |
| 13 May 21 | r04 | UniversitarioUniversitario | 1 - 1 | Defensa y JusticiaDefensa y Jus |
| 13 May 21 | r04 | Atlético NacionalAtlético Naci | 0 - 0 | Nacional MontevideoNacional Mont |
| 13 May 21 | r04 | Velez SarsfieldVelez Sarsfie | 3 - 1 | LDU QuitoLDU Quito |
| 14 May 21 | r04 | Always ReadyAlways Ready | 1 - 2 | Club OlimpiaClub Olimpia |
| 14 May 21 | r04 | América de CaliAmérica de Ca | 1 - 3 | Atletico MGAtletico MG |
| |
| 18 May 21 | r05 | PalmeirasPalmeiras | 3 - 4 | Defensa y JusticiaDefensa y Jus |
| 18 May 21 | r05 | The StrongestThe Strongest | 2 - 1 | Santos FCSantos FC |
| 18 May 21 | r05 | Nacional MontevideoNacional Mont | 1 - 0 | Universidad CatólicaUniversidad C |
| 19 May 21 | r05 | UniversitarioUniversitario | 3 - 2 | Independiente del ValleIndependiente |
| 19 May 21 | r05 | FluminenseFluminense | 1 - 2 | Atlético JuniorAtlético Juni |
| 19 May 21 | r05 | Sao PauloSao Paulo | 0 - 1 | Racing ClubRacing Club |
| 19 May 21 | r05 | Sporting CristalSporting Cris | 2 - 0 | RentistasRentistas |
| 19 May 21 | r05 | Velez SarsfieldVelez Sarsfie | 2 - 1 | Unión La CaleraUnión La Cale |
| 20 May 21 | r05 | River PlateRiver Plate | 2 - 1 | Independiente Santa FeIndependiente |
| 20 May 21 | r05 | FlamengoFlamengo | 2 - 2 | LDU QuitoLDU Quito |
| 20 May 21 | r05 | Cerro PorteñoCerro Porteño | 0 - 1 | Atletico MGAtletico MG |
| 20 May 21 | r05 | Deportivo Táchira F.C.Deportivo Tác | 7 - 2 | Always ReadyAlways Ready |
| 20 May 21 | r05 | América de CaliAmérica de Ca | 3 - 1 | Real Esppor ClubReal Esppor C |
| 20 May 21 | r05 | Argentinos JuniorsArgentinos Ju | 1 - 0 | Atlético NacionalAtlético Naci |
| 21 May 21 | r05 | Club OlimpiaClub Olimpia | 0 - 1 | InternacionalInternacional |
| 21 May 21 | r05 | Boca JuniorsBoca Juniors | 0 - 0 | Barcelona SCBarcelona SC |
| |
| 25 May 21 | r06 | River PlateRiver Plate | 1 - 3 | FluminenseFluminense |
| 25 May 21 | r06 | Independiente Santa FeIndependiente | 0 - 0 | Atlético JuniorAtlético Juni |
| 26 May 21 | r06 | Sao PauloSao Paulo | 3 - 0 | Sporting CristalSporting Cris |
| 26 May 21 | r06 | Racing ClubRacing Club | 3 - 0 | RentistasRentistas |
| 26 May 21 | r06 | Cerro PorteñoCerro Porteño | 1 - 0 | América de CaliAmérica de Ca |
| 26 May 21 | r06 | Atletico MGAtletico MG | 4 - 0 | Real Esppor ClubReal Esppor C |
| 26 May 21 | r06 | Club OlimpiaClub Olimpia | 6 - 2 | Deportivo Táchira F.C.Deportivo Tác |
| 26 May 21 | r06 | InternacionalInternacional | 0 - 0 | Always ReadyAlways Ready |
| 27 May 21 | r06 | Boca JuniorsBoca Juniors | 3 - 0 | The StrongestThe Strongest |
| 27 May 21 | r06 | Barcelona SCBarcelona SC | 3 - 1 | Santos FCSantos FC |
| 27 May 21 | r06 | Nacional MontevideoNacional Mont | 2 - 0 | Argentinos JuniorsArgentinos Ju |
| 27 May 21 | r06 | Universidad CatólicaUniversidad C | 2 - 0 | Atlético NacionalAtlético Naci |
| 27 May 21 | r06 | PalmeirasPalmeiras | 6 - 0 | UniversitarioUniversitario |
| 27 May 21 | r06 | Defensa y JusticiaDefensa y Jus | 1 - 1 | Independiente del ValleIndependiente |
| 28 May 21 | r06 | FlamengoFlamengo | 0 - 0 | Velez SarsfieldVelez Sarsfie |
| 28 May 21 | r06 | LDU QuitoLDU Quito | 5 - 2 | Unión La CaleraUnión La Cale |
| |
| 13 Jul 21 | r16 | Boca JuniorsBoca Juniors | 0 - 0 | Atletico MGAtletico MG |
| 13 Jul 21 | r16 | Cerro PorteñoCerro Porteño | 0 - 2 | FluminenseFluminense |
| 14 Jul 21 | r16 | Sao PauloSao Paulo | 1 - 1 | Racing ClubRacing Club |
| 14 Jul 21 | r16 | Velez SarsfieldVelez Sarsfie | 1 - 0 | Barcelona SCBarcelona SC |
| 14 Jul 21 | r16 | Universidad CatólicaUniversidad C | 0 - 1 | PalmeirasPalmeiras |
| 15 Jul 21 | r16 | River PlateRiver Plate | 1 - 1 | Argentinos JuniorsArgentinos Ju |
| 15 Jul 21 | r16 | Defensa y JusticiaDefensa y Jus | 0 - 1 | FlamengoFlamengo |
| 16 Jul 21 | r16 | Club OlimpiaClub Olimpia | 0 - 0 | InternacionalInternacional |
| 20 Jul 21 | r16 | Atletico MGAtletico MG | 0 - 0 | Boca JuniorsBoca Juniors |
| 21 Jul 21 | r16 | Racing ClubRacing Club | 1 - 3 | Sao PauloSao Paulo |
| 21 Jul 21 | r16 | PalmeirasPalmeiras | 1 - 0 | Universidad CatólicaUniversidad C |
| 21 Jul 21 | r16 | Barcelona SCBarcelona SC | 3 - 1 | Velez SarsfieldVelez Sarsfie |
| 22 Jul 21 | r16 | FlamengoFlamengo | 4 - 1 | Defensa y JusticiaDefensa y Jus |
| 22 Jul 21 | r16 | Argentinos JuniorsArgentinos Ju | 0 - 2 | River PlateRiver Plate |
| 23 Jul 21 | r16 | InternacionalInternacional | 0 - 0 | Club OlimpiaClub Olimpia |
| 03 Aug 21 | r16 | FluminenseFluminense | 1 - 0 | Cerro PorteñoCerro Porteño |
| |
| 11 Aug 21 | QF | Sao PauloSao Paulo | 1 - 1 | PalmeirasPalmeiras |
| 11 Aug 21 | QF | Club OlimpiaClub Olimpia | 1 - 4 | FlamengoFlamengo |
| 12 Aug 21 | QF | River PlateRiver Plate | 0 - 1 | Atletico MGAtletico MG |
| 13 Aug 21 | QF | FluminenseFluminense | 2 - 2 | Barcelona SCBarcelona SC |
| 18 Aug 21 | QF | PalmeirasPalmeiras | 3 - 0 | Sao PauloSao Paulo |
| 18 Aug 21 | QF | FlamengoFlamengo | 5 - 1 | Club OlimpiaClub Olimpia |
| 19 Aug 21 | QF | Atletico MGAtletico MG | 3 - 0 | River PlateRiver Plate |
| 20 Aug 21 | QF | Barcelona SCBarcelona SC | 1 - 1 | FluminenseFluminense |
| |
| 22 Sep 21 | SF | PalmeirasPalmeiras | 0 - 0 | Atletico MGAtletico MG |
| 23 Sep 21 | SF | FlamengoFlamengo | 2 - 0 | Barcelona SCBarcelona SC |
| 29 Sep 21 | SF | Atletico MGAtletico MG | 1 - 1 | PalmeirasPalmeiras |
| 30 Sep 21 | SF | Barcelona SCBarcelona SC | 0 - 2 | FlamengoFlamengo |
| |
| 27 Nov 21 | Final | PalmeirasPalmeiras | 2 - 1 | FlamengoFlamengo |
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