| 08 Jun 22 | r32  | Ferro Carril OesteFerro Carril | 0 - 1 | Boca JuniorsBoca Juniors |
| 09 Jun 22 | r32 | Racing ClubRacing Club | 1 - 2 | AgropecuarioAgropecuario |
| 09 Jun 22 | r32 | Velez SarsfieldVelez Sarsfie | 1 - 0 | Independiente RivadaviaIndependiente |
| 15 Jun 22 | r32 | Gimnasia y Esgrima de JujGimnasia y Es | 1 - 0 | Racing CordobaRacing Cordob |
| 22 Jun 22 | r32  | Patronato de ParanaPatronato de | 1 - 1 | ColonColon |
| 23 Jun 22 | r32 | Chaco For EverChaco For Eve | 0 - 0 | Talleres de CordobaTalleres de C |
| 24 Jun 22 | r32 | Atletico TucumanAtletico Tucu | 0 - 1 | IndependienteIndependiente |
| 29 Jun 22 | r32 | Gimnasia LPGimnasia LP | 2 - 0 | CSD FlandriaCSD Flandria |
| 06 Jul 22 | r32 | Argentinos JuniorsArgentinos Ju | 0 - 1 | Defensa y JusticiaDefensa y Jus |
| 13 Jul 22 | r32 | BanfieldBanfield | 2 - 1 | UnionUnion |
| 13 Jul 22 | r32 | BelgranoBelgrano | 1 - 0 | Estudiantes de la PlataEstudiantes d |
| 13 Jul 22 | r32 | LanusLanus | 1 - 3 | Godoy CruzGodoy Cruz |
| 14 Jul 22 | r32 | Barracas CentralBarracas Cent | 0 - 3 | River PlateRiver Plate |
| 27 Jul 22 | r32 | TigreTigre | 3 - 3 | Deportivo MadrynDeportivo Mad |
| 04 Aug 22 | r32 | AldosiviAldosivi | 2 - 4 | Newells Old BoysNewells Old B |
| 04 Aug 22 | r32 | Rosario CentralRosario Centr | 1 - 1 | QuilmesQuilmes |
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