| 23 Feb 22 | r01  | LanusLanus | 5 - 0 | Defensores de CambaceresDefensores de |
| 24 Feb 22 | r01 | Independiente RivadaviaIndependiente | 2 - 0 | Gimnasia y EsgrimaGimnasia y Es |
| 25 Feb 22 | r01 | Almirante BrownAlmirante Bro | 0 - 2 | AgropecuarioAgropecuario |
| 01 Mar 22 | r01 | Velez SarsfieldVelez Sarsfie | 5 - 0 | Club CipollettiClub Cipollet |
| 02 Mar 22 | r01 | ColonColon | 2 - 1 | Club Sportivo PeñarolClub Sportivo |
| 02 Mar 22 | r01 | BanfieldBanfield | 3 - 1 | Sportivo Dock SudSportivo Dock |
| 03 Mar 22 | r01 | Boca JuniorsBoca Juniors | 4 - 1 | Central Córdoba de RosariCentral Córdo |
| 09 Mar 22 | r01 | Argentinos JuniorsArgentinos Ju | 2 - 0 | OlimpoOlimpo |
| 10 Mar 22 | r01 | River PlateRiver Plate | 5 - 0 | LaferrereLaferrere |
| 16 Mar 22 | r01 | Arsenal SarandiArsenal Saran | 0 - 0 | Chaco For EverChaco For Eve |
| 16 Mar 22 | r01 | Talleres de CordobaTalleres de C | 4 - 0 | GüemesGüemes |
| 23 Mar 22 | r01 | UnionUnion | 1 - 1 | Sportivo Las ParejasSportivo Las |
| 25 Mar 22 | r01 | Estudiantes de la PlataEstudiantes d | 2 - 1 | Puerto NuevoPuerto Nuevo |
| 26 Mar 22 | r01 | IndependienteIndependiente | 1 - 1 | Central NorteCentral Norte |
| 28 Mar 22 | r01 | Racing ClubRacing Club | 3 - 1 | Gimnasia Y TiroGimnasia Y Ti |
| 01 Apr 22 | r01 | Defensa y JusticiaDefensa y Jus | 4 - 1 | Sacachispas FCSacachispas F |
| 05 Apr 22 | r01 | Central Córdoba de SantiaCentral Córdo | 0 - 0 | Gimnasia y Esgrima de JujGimnasia y Es |
| 14 Apr 22 | r01 | San LorenzoSan Lorenzo | 1 - 1 | Racing CordobaRacing Cordob |
| 20 Apr 22 | r01 | Ferro Carril OesteFerro Carril | 4 - 0 | JJ UrquizaJJ Urquiza |
| 27 Apr 22 | r01 | QuilmesQuilmes | 2 - 0 | San Martin de TucumanSan Martin de |
| 28 Apr 22 | r01 | Atletico TucumanAtletico Tucu | 2 - 0 | Brown de AdroguéBrown de Adro |
| 03 May 22 | r01 | AldosiviAldosivi | 1 - 1 | Club Atlético ColegialesClub Atlético |
| 04 May 22 | r01 | SarmientoSarmiento | 0 - 2 | CSD FlandriaCSD Flandria |
| 04 May 22 | r01 | Newells Old BoysNewells Old B | 3 - 1 | ItuzaingóItuzaingó |
| 12 May 22 | r01  | Barracas CentralBarracas Cent | 4 - 1 | Club Atlético AcassusoClub Atlético |
| 13 May 22 | r01 | Rosario CentralRosario Centr | 1 - 1 | Club Sol De MayoClub Sol De M |
| 14 May 22 | r01 | Patronato de ParanaPatronato de | 2 - 0 | Deportivo MorónDeportivo Mor |
| 14 May 22 | r01 | Godoy CruzGodoy Cruz | 2 - 0 | Tristán SuárezTristán Suáre |
| 24 May 22 | r01 | HuracanHuracan | 0 - 0 | Deportivo MadrynDeportivo Mad |
| 25 May 22 | r01 | PlatensePlatense | 1 - 1 | BelgranoBelgrano |
| 25 May 22 | r01 | Gimnasia LPGimnasia LP | 1 - 0 | Club LiniersClub Liniers |
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