| 26 Oct 21 | r02    | HoffenheimHoffenheim | 5 - 1 | Holstein KielHolstein Kiel |
| 26 Oct 21 | r02 | Munich 1860Munich 1860 | 1 - 0 | Schalke 04Schalke 04 |
| 26 Oct 21 | r02 | SV BabelsbergSV Babelsberg | 0 - 1 | RasenBallsport LeipzigRasenBallspor |
| 26 Oct 21 | r02 | Preußen MünsterPreußen Münst | 1 - 3 | HerthaHertha |
| 26 Oct 21 | r02 | DortmundDortmund | 2 - 0 | IngolstadtIngolstadt |
| 26 Oct 21 | r02 | MainzMainz | 3 - 2 | BielefeldBielefeld |
| 26 Oct 21 | r02 | NurnbergNurnberg | 1 - 1 | HamburgHamburg |
| 26 Oct 21 | r02 | OsnabrueckOsnabrueck | 2 - 2 | FreiburgFreiburg |
| 27 Oct 21 | r02 | Dynamo DresdenDynamo Dresde | 2 - 3 | St PauliSt Pauli |
| 27 Oct 21 | r02 | LeverkusenLeverkusen | 1 - 2 | KarlsruheKarlsruhe |
| 27 Oct 21 | r02 | Dynamo DresdenDynamo Dresde | 2 - 3 | St PauliSt Pauli |
| 27 Oct 21 | r02  | BochumBochum | 2 - 2 | AugsburgAugsburg |
| 27 Oct 21 | r02 | Waldhof MannheimWaldhof Mannh | 1 - 3 | Union BerlinUnion Berlin |
| 27 Oct 21 | r02 | MönchengladbachMönchengladba | 5 - 0 | Bayern MunichBayern Munich |
| 27 Oct 21 | r02 | Jahn RegensburgJahn Regensbu | 3 - 4 | Hansa RostockHansa Rostock |
| 27 Oct 21 | r02 | HannoverHannover | 3 - 0 | Fortuna DüsseldorfFortuna Düsse |
| 27 Oct 21 | r02 | StuttgartStuttgart | 0 - 2 | FC KolnFC Koln |
| 27 Oct 21 | r02 | Jahn RegensburgJahn Regensbu | 3 - 3 | Hansa RostockHansa Rostock |
| 27 Oct 21 | r02 | HannoverHannover | 3 - 0 | Fortuna DüsseldorfFortuna Düsse |
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