| 04 Feb 22 | r04        | Manchester UnitedManchester Un | 1 - 1 | MiddlesbroughMiddlesbrough |
| 05 Feb 22 | r04        | ChelseaChelsea | 2 - 1 | PlymouthPlymouth |
| 05 Feb 22 | r04        | Kidderminster HarriersKidderminster | 1 - 2 | West HamWest Ham |
| 05 Feb 22 | r04        | Crystal PalaceCrystal Palac | 2 - 0 | HartlepoolHartlepool |
| 05 Feb 22 | r04        | Huddersfield TownHuddersfield | 1 - 0 | BarnsleyBarnsley |
| 05 Feb 22 | r04        | PeterboroPeterboro | 2 - 0 | QPRQPR |
| 05 Feb 22 | r04        | SouthamptonSouthampton | 2 - 1 | CoventryCoventry |
| 05 Feb 22 | r04        | EvertonEverton | 4 - 1 | BrentfordBrentford |
| 05 Feb 22 | r04        | StokeStoke | 2 - 0 | WiganWigan |
| 05 Feb 22 | r04        | Manchester CityManchester Ci | 4 - 1 | FulhamFulham |
| 05 Feb 22 | r04        | WolvesWolves | 0 - 1 | NorwichNorwich |
| 05 Feb 22 | r04        | Cambridge UnitedCambridge Uni | 0 - 3 | LutonLuton |
| 05 Feb 22 | r04        | TottenhamTottenham | 3 - 1 | BrightonBrighton |
| 06 Feb 22 | r04        | LiverpoolLiverpool | 3 - 1 | CardiffCardiff |
| 06 Feb 22 | r04        | Nottingham F.Nottingham F. | 4 - 1 | LeicesterLeicester |
| 06 Feb 22 | r04        | BournemouthBournemouth | 0 - 1 | Boreham WoodBoreham Wood |