| 08 Jan 21 | r03     | WolvesWolves | 1 - 0 | Crystal PalaceCrystal Palac |
| 08 Jan 21 | r03 | Aston VillaAston Villa | 1 - 4 | LiverpoolLiverpool |
| 09 Jan 21 | r03 | EvertonEverton | 2 - 1 | RotherhamRotherham |
| 09 Jan 21 | r03 | Nottingham F.Nottingham F. | 1 - 0 | CardiffCardiff |
| 09 Jan 21 | r03 | LutonLuton | 1 - 0 | ReadingReading |
| 09 Jan 21 | r03 | NorwichNorwich | 2 - 0 | CoventryCoventry |
| 09 Jan 21 | r03 | Boreham WoodBoreham Wood | 0 - 2 | MillwallMillwall |
| 09 Jan 21 | r03 | ChorleyChorley | 2 - 0 | DerbyDerby |
| 09 Jan 21 | r03 | OldhamOldham | 4 - 1 | BournemouthBournemouth |
| 09 Jan 21 | r03 | StevenageStevenage | 0 - 2 | SwanseaSwansea |
| 09 Jan 21 | r03 | Bristol RoversBristol Rover | 2 - 3 | Sheffield UnitedSheffield Uni |
| 09 Jan 21 | r03 | BlackburnBlackburn | 0 - 1 | DoncasterDoncaster |
| 09 Jan 21 | r03 | StokeStoke | 0 - 4 | LeicesterLeicester |
| 09 Jan 21 | r03 | WycombeWycombe | 4 - 1 | PrestonPreston |
| 09 Jan 21 | r03 | QPRQPR | 0 - 2 | FulhamFulham |
| 09 Jan 21 | r03 | ExeterExeter | 0 - 2 | Sheffield WedsSheffield Wed |
| 09 Jan 21 | r03 | BlackpoolBlackpool | 2 - 2 | West BromWest Brom |
| 09 Jan 21 | r03 | BurnleyBurnley | 1 - 1 | Milton Keynes DonsMilton Keynes |
| 09 Jan 21 | r03 | ArsenalArsenal | 2 - 0 | NewcastleNewcastle |
| 09 Jan 21 | r03 | Huddersfield TownHuddersfield | 2 - 3 | PlymouthPlymouth |
| 09 Jan 21 | r03 | BrentfordBrentford | 2 - 1 | MiddlesbroughMiddlesbrough |
| 09 Jan 21 | r03 | Manchester UnitedManchester Un | 1 - 0 | WatfordWatford |
| 10 Jan 21 | r03 | BarnsleyBarnsley | 2 - 0 | TranmereTranmere |
| 10 Jan 21 | r03 | CrawleyCrawley | 3 - 0 | LeedsLeeds |
| 10 Jan 21 | r03 | Bristol CityBristol City | 2 - 1 | PortsmouthPortsmouth |
| 10 Jan 21 | r03 | Manchester CityManchester Ci | 3 - 0 | BirminghamBirmingham |
| 10 Jan 21 | r03 | ChelseaChelsea | 4 - 0 | MorecambeMorecambe |
| 10 Jan 21 | r03 | CheltenhamCheltenham | 2 - 1 | MansfieldMansfield |
| 10 Jan 21 | r03 | MarineMarine | 0 - 5 | TottenhamTottenham |
| 10 Jan 21 | r03  | NewportNewport | 1 - 1 | BrightonBrighton |
| 11 Jan 21 | r03 | StockportStockport | 0 - 1 | West HamWest Ham |
| 19 Jan 21 | r03 | SouthamptonSouthampton | 2 - 0 | ShrewsburyShrewsbury |
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