| 03 Dec 20 | r05    | AEKAEK | 2 - 4 | BragaBraga |
| 03 Dec 20 | r05 | ZoryaZorya | 1 - 0 | LeicesterLeicester |
| 03 Dec 20 | r05 | MilanMilan | 4 - 2 | CelticCeltic |
| 03 Dec 20 | r05 | LilleLille | 2 - 1 | Sparta PragueSparta Prague |
| 03 Dec 20 | r05 | Qarabag FKQarabag FK | 1 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 03 Dec 20 | r05 | SivassporSivasspor | 0 - 1 | VillarrealVillarreal |
| 03 Dec 20 | r05 | LASKLASK | 3 - 3 | TottenhamTottenham |
| 03 Dec 20 | r05 | AntwerpAntwerp | 3 - 1 | Ludogorets RazgradLudogorets Ra |
| 03 Dec 20 | r05 | CSKA MoscowCSKA Moscow | 0 - 1 | Wolfsberger ACWolfsberger A |
| 03 Dec 20 | r05 | FeyenoordFeyenoord | 0 - 2 | Dinamo ZagrebDinamo Zagreb |
| 03 Dec 20 | r05 | Crvena ZvezdaCrvena Zvezda | 0 - 0 | HoffenheimHoffenheim |
| 03 Dec 20 | r05 | GentGent | 1 - 2 | LiberecLiberec |
| 03 Dec 20 | r05 | RomaRoma | 3 - 1 | Young BoysYoung Boys |
| 03 Dec 20 | r05 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 0 | CSKA SofiaCSKA Sofia |
| 03 Dec 20 | r05 | ArsenalArsenal | 4 - 1 | Rapid ViennaRapid Vienna |
| 03 Dec 20 | r05 | MoldeMolde | 3 - 1 | DundalkDundalk |
| 03 Dec 20 | r05 | Slavia PragueSlavia Prague | 3 - 0 | Hapoel Beer ShevaHapoel Beer S |
| 03 Dec 20 | r05 | NiceNice | 2 - 3 | LeverkusenLeverkusen |
| 03 Dec 20 | r05 | BenficaBenfica | 4 - 0 | Lech PoznanLech Poznan |
| 03 Dec 20 | r05 | RangersRangers | 3 - 2 | StandardStandard |
| 03 Dec 20 | r05 | Omonia NicosiaOmonia Nicosi | 2 - 1 | PAOKPAOK |
| 03 Dec 20 | r05 | GranadaGranada | 0 - 1 | PSV EindhovenPSV Eindhoven |
| 03 Dec 20 | r05 | AZ AlkmaarAZ Alkmaar | 1 - 1 | NapoliNapoli |
| 03 Dec 20 | r05 | SociedadSociedad | 2 - 2 | RijekaRijeka |
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