| 25 Aug 20 | Qualifier        | FK RiteriaiFK Riteriai | 3 - 2 | Derry CityDerry City |
| 26 Aug 20 | Qualifier        | Progrès NiederkornProgrès Niede | 3 - 0 | ZetaZeta |
| 27 Aug 20 | Qualifier        | Ordabasy ShymkentOrdabasy Shym | 1 - 2 | FC BotoșaniFC Botoșani |
| 27 Aug 20 | Qualifier        | FK VentspilsFK Ventspils | 2 - 1 | Dinamo-Auto TiraspolDinamo-Auto T |
| 27 Aug 20 | Qualifier        | Kairat AlmatyKairat Almaty | 4 - 1 | NoahNoah |
| 27 Aug 20 | Qualifier        | KS Teuta KS Teuta | 2 - 0 | Beitar JerusalemBeitar Jerusa |
| 27 Aug 20 | Qualifier        | Borac Banja LukaBorac Banja L | 1 - 0 | SutjeskaSutjeska |
| 27 Aug 20 | Qualifier        | Dinamo MinskDinamo Minsk | 0 - 2 | Piast GliwicePiast Gliwice |
| 27 Aug 20 | Qualifier        | Lincoln Red ImpsLincoln Red I | 2 - 0 | UT PétangeUT Pétange |
| 27 Aug 20 | Qualifier        | Olimpija LjubljanaOlimpija Ljub | 2 - 1 | Víkingur ReykjavikVíkingur Reyk |
| 27 Aug 20 | Qualifier        | Neftçi PFKNeftçi PFK | 2 - 1 | ShkupiShkupi |
| 27 Aug 20 | Qualifier        | Bodoe/GlimtBodoe/Glimt | 6 - 1 | Kauno ŽalgirisKauno Žalgiri |
| 27 Aug 20 | Qualifier        | AlashkertAlashkert | 0 - 1 | RenovaRenova |
| 27 Aug 20 | Qualifier        | Apollon LimassolApollon Limas | 5 - 1 | Saburtalo TbilisiSaburtalo Tbi |
| 27 Aug 20 | Qualifier        | Sumgayit FKSumgayit FK | 0 - 2 | Shkendija 79Shkendija 79 |
| 27 Aug 20 | Qualifier        | Videoton FC FehervarVideoton FC F | 1 - 1 | BohemiansBohemians |
| 27 Aug 20 | Qualifier        | HammarbyHammarby | 3 - 0 | Puskás Akadémia FCPuskás Akadém |
| 27 Aug 20 | Qualifier        | AGF AarhusAGF Aarhus | 5 - 2 | HonkaHonka |
| 27 Aug 20 | Qualifier        | VaduzVaduz | 0 - 2 | Hibernians FCHibernians FC |
| 27 Aug 20 | Qualifier        | GjilaniGjilani | 0 - 2 | Apoel NicosiaApoel Nicosia |
| 27 Aug 20 | Qualifier        | RosenborgRosenborg | 4 - 2 | BreidablikBreidablik |
| 27 Aug 20 | Qualifier        | VMFD ZalgirisVMFD Zalgiris | 2 - 0 | Paide LinnameeskondPaide Linname |
| 27 Aug 20 | Qualifier        | Malmo FFMalmo FF | 2 - 0 | Cracovia KrakowCracovia Krak |
| 27 Aug 20 | Qualifier        | Keşla FKKeşla FK | 0 - 0 | LaciLaci |
| 27 Aug 20 | Qualifier        | CSKA SofiaCSKA Sofia | 2 - 1 | Sirens FCSirens FC |
| 27 Aug 20 | Qualifier        | Locomotive TbilisiLocomotive Tb | 2 - 1 | Universitatea CraiovaUniversitatea |
| 27 Aug 20 | Qualifier        | KukesiKukesi | 2 - 1 | Slavia SofiaSlavia Sofia |
| 27 Aug 20 | Qualifier        | Petrocub HînceștiPetrocub Hînc | 0 - 2 | TSC Bačka TopolaTSC Bačka Top |
| 27 Aug 20 | Qualifier        | FH Hafnarfjordur FH Hafnarfjor | 0 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 27 Aug 20 | Qualifier        | TNSTNS | 3 - 1 | MSK ZilinaMSK Zilina |
| 27 Aug 20 | Qualifier        | Shakhter SoligorskShakhter Soli | 0 - 0 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 27 Aug 20 | Qualifier        | Hapoel Beer ShevaHapoel Beer S | 3 - 0 | Dinamo BatumiDinamo Batumi |
| 27 Aug 20 | Qualifier        | B36 TorshavnB36 Torshavn | 4 - 3 | FC Levadia TallinnFC Levadia Ta |
| 27 Aug 20 | Qualifier        | Iskra DanilovgradIskra Danilov | 0 - 1 | Lokomotiv Plovdiv Lokomotiv Plo |
| 27 Aug 20 | Qualifier        | ZrinjskiZrinjski | 3 - 0 | FC 03 Differdange FC 03 Differd |
| 27 Aug 20 | Qualifier        | VallettaValletta | 0 - 1 | BalaBala |
| 27 Aug 20 | Qualifier        | Partizan BelgradePartizan Belg | 1 - 0 | Rīgas Futbola SkolaRīgas Futbola |
| 27 Aug 20 | Qualifier        | ServetteServette | 3 - 0 | MFK RužomberokMFK Ružombero |
| 27 Aug 20 | Qualifier        | Steaua BucurestiSteaua Bucure | 3 - 0 | Shirak GyumriShirak Gyumri |
| 27 Aug 20 | Qualifier        | NK MariborNK Maribor | 1 - 1 | ColeraineColeraine |
| 27 Aug 20 | Qualifier        | AberdeenAberdeen | 6 - 0 | NSI RunavikNSI Runavik |
| 27 Aug 20 | Qualifier        | MotherwellMotherwell | 5 - 1 | GlentoranGlentoran |
| 27 Aug 20 | Qualifier        | Kispest HonvedKispest Honve | 2 - 1 | Inter TurkuInter Turku |
| 27 Aug 20 | Qualifier        | ShamrockShamrock | 2 - 2 | IlvesIlves |
| 27 Aug 20 | Qualifier        | Lech PoznanLech Poznan | 3 - 0 | Valmieras FKValmieras FK |
| 09 Sep 20 | Qualifier        | Maccabi HaifaMaccabi Haifa | 3 - 1 | ZeljeznicarZeljeznicar |
| 10 Sep 20 | Qualifier        | Nomme KaljuNomme Kalju | 0 - 4 | NŠ MuraNŠ Mura |
| 16 Sep 20 | Qualifier        | Progrès NiederkornProgrès Niede | 0 - 5 | Willem IIWillem II |
| 16 Sep 20 | Qualifier        | HammarbyHammarby | 0 - 3 | Lech PoznanLech Poznan |
| 16 Sep 20 | Qualifier        | B36 TorshavnB36 Torshavn | 2 - 2 | TNSTNS |
| 17 Sep 20 | Qualifier        | Kaisar KyzylordaKaisar Kyzylo | 1 - 4 | Apoel NicosiaApoel Nicosia |
| 17 Sep 20 | Qualifier        | FK VentspilsFK Ventspils | 1 - 5 | RosenborgRosenborg |
| 17 Sep 20 | Qualifier        | RenovaRenova | 0 - 1 | Hajduk SplitHajduk Split |
| 17 Sep 20 | Qualifier        | FC AstanaFC Astana | 0 - 1 | Buducnost PodgoricaBuducnost Pod |
| 17 Sep 20 | Qualifier        | KS Teuta KS Teuta | 0 - 4 | GranadaGranada |
| 17 Sep 20 | Qualifier        | Ararat-ArmeniaArarat-Armeni | 4 - 3 | FolaFola |
| 17 Sep 20 | Qualifier        | Lincoln Red ImpsLincoln Red I | 0 - 5 | RangersRangers |
| 17 Sep 20 | Qualifier        | KuPS KuopioKuPS Kuopio | 1 - 1 | Slovan BratislavaSlovan Bratis |
| 17 Sep 20 | Qualifier        | Olimpija LjubljanaOlimpija Ljub | 2 - 3 | ZrinjskiZrinjski |
| 17 Sep 20 | Qualifier        | FC BotoșaniFC Botoșani | 0 - 1 | Shkendija 79Shkendija 79 |
| 17 Sep 20 | Qualifier        | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 2 | TottenhamTottenham |
| 17 Sep 20 | Qualifier        | Neftçi PFKNeftçi PFK | 1 - 3 | GalatasarayGalatasaray |
| 17 Sep 20 | Qualifier        | IFK GothenburgIFK Gothenbur | 1 - 2 | FC CopenhagenFC Copenhagen |
| 17 Sep 20 | Qualifier        | FK RiteriaiFK Riteriai | 1 - 5 | LiberecLiberec |
| 17 Sep 20 | Qualifier        | Bodoe/GlimtBodoe/Glimt | 3 - 1 | VMFD ZalgirisVMFD Zalgiris |
| 17 Sep 20 | Qualifier        | Sfântul Gheorghe SuruceniSfântul Gheor | 0 - 1 | Partizan BelgradePartizan Belg |
| 17 Sep 20 | Qualifier        | FC Flora TallinFC Flora Tall | 2 - 1 | KR ReykjavikKR Reykjavik |
| 17 Sep 20 | Qualifier        | Connah's Quay NomadsConnah's Quay | 0 - 1 | Dinamo TbilisiDinamo Tbilis |
| 17 Sep 20 | Qualifier        | Locomotive TbilisiLocomotive Tb | 2 - 1 | Dinamo MoscowDinamo Moscow |
| 17 Sep 20 | Qualifier        | CSKA SofiaCSKA Sofia | 2 - 0 | BATE BorisovBATE Borisov |
| 17 Sep 20 | Qualifier        | LaciLaci | 1 - 2 | Hapoel Beer ShevaHapoel Beer S |
| 17 Sep 20 | Qualifier        | Hibernians FCHibernians FC | 0 - 1 | Videoton FC FehervarVideoton FC F |
| 17 Sep 20 | Qualifier        | OFIOFI | 0 - 1 | Apollon LimassolApollon Limas |
| 17 Sep 20 | Qualifier        | KukesiKukesi | 0 - 4 | WolfsburgWolfsburg |
| 17 Sep 20 | Qualifier        | Maccabi HaifaMaccabi Haifa | 2 - 1 | Kairat AlmatyKairat Almaty |
| 17 Sep 20 | Qualifier        | Inter Club d'EscaldesInter Club d' | 0 - 1 | DundalkDundalk |
| 17 Sep 20 | Qualifier        | ShamrockShamrock | 0 - 2 | MilanMilan |
| 17 Sep 20 | Qualifier        | Piast GliwicePiast Gliwice | 3 - 2 | TSV HartbergTSV Hartberg |
| 17 Sep 20 | Qualifier        | Borac Banja LukaBorac Banja L | 0 - 2 | Rio AveRio Ave |
| 17 Sep 20 | Qualifier        | SileksSileks | 0 - 2 | DritaDrita |
| 17 Sep 20 | Qualifier        | StandardStandard | 2 - 0 | BalaBala |
| 17 Sep 20 | Qualifier        | ArisAris | 1 - 2 | FC Kolos KovalivkaFC Kolos Kova |
| 17 Sep 20 | Qualifier        | NŠ MuraNŠ Mura | 3 - 0 | AGF AarhusAGF Aarhus |
| 17 Sep 20 | Qualifier        | ColeraineColeraine | 2 - 2 | MotherwellMotherwell |
| 17 Sep 20 | Qualifier        | VikingViking | 0 - 2 | AberdeenAberdeen |
| 17 Sep 20 | Qualifier        | ServetteServette | 0 - 1 | Stade de ReimsStade de Reim |
| 17 Sep 20 | Qualifier        | OsijekOsijek | 1 - 2 | FC BaselFC Basel |
| 17 Sep 20 | Qualifier        | LinfieldLinfield | 0 - 1 | Floriana FCFloriana FC |
| 17 Sep 20 | Qualifier        | DAC 1904 Dunajská StredaDAC 1904 Duna | 5 - 3 | JablonecJablonec |
| 17 Sep 20 | Qualifier        | TSC Bačka TopolaTSC Bačka Top | 6 - 6 | Steaua BucurestiSteaua Bucure |
| 17 Sep 20 | Qualifier        | Kispest HonvedKispest Honve | 0 - 2 | Malmo FFMalmo FF |
| 18 Sep 20 | Qualifier        | Riga FCRiga FC | 1 - 0 | Tre FioriTre Fiori |
| 23 Sep 20 | Qualifier        | Apollon LimassolApollon Limas | 0 - 5 | Lech PoznanLech Poznan |
| 24 Sep 20 | Qualifier        | Ararat-ArmeniaArarat-Armeni | 1 - 0 | CeljeCelje |
| 24 Sep 20 | Qualifier        | KuPS KuopioKuPS Kuopio | 2 - 0 | FK Suduva FK Suduva |
| 24 Sep 20 | Qualifier        | Viktoria PlzenViktoria Plze | 3 - 0 | SønderjyskeSønderjyske |
| 24 Sep 20 | Qualifier        | Videoton FC FehervarVideoton FC F | 0 - 0 | Stade de ReimsStade de Reim |
| 24 Sep 20 | Qualifier        | BesiktasBesiktas | 1 - 1 | Rio AveRio Ave |
| 24 Sep 20 | Qualifier        | FK RostovFK Rostov | 1 - 2 | Maccabi HaifaMaccabi Haifa |
| 24 Sep 20 | Qualifier        | Malmo FFMalmo FF | 5 - 0 | NK LokomotivaNK Lokomotiva |
| 24 Sep 20 | Qualifier        | RosenborgRosenborg | 1 - 0 | AlanyasporAlanyaspor |
| 24 Sep 20 | Qualifier        | FC CopenhagenFC Copenhagen | 3 - 0 | Piast GliwicePiast Gliwice |
| 24 Sep 20 | Qualifier        | CSKA SofiaCSKA Sofia | 3 - 1 | B36 TorshavnB36 Torshavn |
| 24 Sep 20 | Qualifier        | DjurgaardenDjurgaarden | 0 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 24 Sep 20 | Qualifier        | Floriana FCFloriana FC | 0 - 0 | FC Flora TallinFC Flora Tall |
| 24 Sep 20 | Qualifier        | CharleroiCharleroi | 2 - 1 | Partizan BelgradePartizan Belg |
| 24 Sep 20 | Qualifier        | NŠ MuraNŠ Mura | 1 - 5 | PSV EindhovenPSV Eindhoven |
| 24 Sep 20 | Qualifier        | Riga FCRiga FC | 0 - 1 | CelticCeltic |
| 24 Sep 20 | Qualifier        | Steaua BucurestiSteaua Bucure | 0 - 2 | LiberecLiberec |
| 24 Sep 20 | Qualifier        | Hapoel Beer ShevaHapoel Beer S | 3 - 0 | MotherwellMotherwell |
| 24 Sep 20 | Qualifier        | Shkendija 79Shkendija 79 | 1 - 3 | TottenhamTottenham |
| 24 Sep 20 | Qualifier        | GranadaGranada | 2 - 0 | Locomotive TbilisiLocomotive Tb |
| 24 Sep 20 | Qualifier        | StandardStandard | 2 - 1 | VojvodinaVojvodina |
| 24 Sep 20 | Qualifier        | GalatasarayGalatasaray | 2 - 0 | Hajduk SplitHajduk Split |
| 24 Sep 20 | Qualifier        | Apoel NicosiaApoel Nicosia | 2 - 2 | ZrinjskiZrinjski |
| 24 Sep 20 | Qualifier        | Sheriff TiraspolSheriff Tiras | 1 - 1 | DundalkDundalk |
| 24 Sep 20 | Qualifier        | FK SarajevoFK Sarajevo | 2 - 1 | Buducnost PodgoricaBuducnost Pod |
| 24 Sep 20 | Qualifier        | KÍ KlaksvíkKÍ Klaksvík | 6 - 1 | Dinamo TbilisiDinamo Tbilis |
| 24 Sep 20 | Qualifier        | WolfsburgWolfsburg | 2 - 0 | DesnaDesna |
| 24 Sep 20 | Qualifier        | St. GallenSt. Gallen | 0 - 1 | AEKAEK |
| 24 Sep 20 | Qualifier        | MilanMilan | 3 - 2 | Bodoe/GlimtBodoe/Glimt |
| 24 Sep 20 | Qualifier        | FC BaselFC Basel | 3 - 2 | Anorthosis FamagustaAnorthosis Fa |
| 24 Sep 20 | Qualifier        | LASKLASK | 7 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 24 Sep 20 | Qualifier        | Legia WarsawLegia Warsaw | 2 - 0 | DritaDrita |
| 24 Sep 20 | Qualifier        | RijekaRijeka | 2 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 24 Sep 20 | Qualifier        | Willem IIWillem II | 0 - 4 | RangersRangers |
| 24 Sep 20 | Qualifier        | Sporting CPSporting CP | 1 - 0 | AberdeenAberdeen |