| 10 Dec 20 | r06    | Young BoysYoung Boys | 2 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 10 Dec 20 | r06 | CSKA SofiaCSKA Sofia | 3 - 1 | RomaRoma |
| 10 Dec 20 | r06 | DundalkDundalk | 2 - 4 | ArsenalArsenal |
| 10 Dec 20 | r06 | Rapid ViennaRapid Vienna | 2 - 2 | MoldeMolde |
| 10 Dec 20 | r06 | LeverkusenLeverkusen | 4 - 0 | Slavia PragueSlavia Prague |
| 10 Dec 20 | r06 | Hapoel Beer ShevaHapoel Beer S | 1 - 0 | NiceNice |
| 10 Dec 20 | r06 | StandardStandard | 2 - 2 | BenficaBenfica |
| 10 Dec 20 | r06 | Lech PoznanLech Poznan | 0 - 2 | RangersRangers |
| 10 Dec 20 | r06 | PSV EindhovenPSV Eindhoven | 4 - 0 | Omonia NicosiaOmonia Nicosi |
| 10 Dec 20 | r06 | PAOKPAOK | 0 - 0 | GranadaGranada |
| 10 Dec 20 | r06 | NapoliNapoli | 1 - 1 | SociedadSociedad |
| 10 Dec 20 | r06 | RijekaRijeka | 2 - 1 | AZ AlkmaarAZ Alkmaar |
| 10 Dec 20 | r06 | BragaBraga | 2 - 0 | ZoryaZorya |
| 10 Dec 20 | r06 | LeicesterLeicester | 2 - 0 | AEKAEK |
| 10 Dec 20 | r06 | CelticCeltic | 3 - 2 | LilleLille |
| 10 Dec 20 | r06 | Sparta PragueSparta Prague | 0 - 1 | MilanMilan |
| 10 Dec 20 | r06 | Maccabi Tel AvivMaccabi Tel A | 1 - 0 | SivassporSivasspor |
| 10 Dec 20 | r06 | VillarrealVillarreal | 3 - 0 | Qarabag FKQarabag FK |
| 10 Dec 20 | r06 | TottenhamTottenham | 2 - 0 | AntwerpAntwerp |
| 10 Dec 20 | r06 | Ludogorets RazgradLudogorets Ra | 1 - 3 | LASKLASK |
| 10 Dec 20 | r06 | Dinamo ZagrebDinamo Zagreb | 3 - 1 | CSKA MoscowCSKA Moscow |
| 10 Dec 20 | r06 | Wolfsberger ACWolfsberger A | 1 - 0 | FeyenoordFeyenoord |
| 10 Dec 20 | r06 | HoffenheimHoffenheim | 4 - 1 | GentGent |
| 10 Dec 20 | r06 | LiberecLiberec | 0 - 0 | Crvena ZvezdaCrvena Zvezda |
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