| 26 Nov 20 | r04    | CSKA SofiaCSKA Sofia | 0 - 1 | Young BoysYoung Boys |
| 26 Nov 20 | r04  | MoldeMolde | 0 - 3 | ArsenalArsenal |
| 26 Nov 20 | r04 | BragaBraga | 3 - 3 | LeicesterLeicester |
| 26 Nov 20 | r04 | AEKAEK | 0 - 3 | ZoryaZorya |
| 26 Nov 20 | r04 | Sparta PragueSparta Prague | 4 - 1 | CelticCeltic |
| 26 Nov 20 | r04 | LilleLille | 1 - 1 | MilanMilan |
| 26 Nov 20 | r04 | Maccabi Tel AvivMaccabi Tel A | 1 - 1 | VillarrealVillarreal |
| 26 Nov 20 | r04 | Qarabag FKQarabag FK | 2 - 3 | SivassporSivasspor |
| 26 Nov 20 | r04 | LASKLASK | 0 - 2 | AntwerpAntwerp |
| 26 Nov 20 | r04 | CSKA MoscowCSKA Moscow | 0 - 0 | FeyenoordFeyenoord |
| 26 Nov 20 | r04 | Wolfsberger ACWolfsberger A | 0 - 3 | Dinamo ZagrebDinamo Zagreb |
| 26 Nov 20 | r04 | GentGent | 0 - 2 | Crvena ZvezdaCrvena Zvezda |
| 26 Nov 20 | r04 | LiberecLiberec | 0 - 2 | HoffenheimHoffenheim |
| 26 Nov 20 | r04 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 2 | RomaRoma |
| 26 Nov 20 | r04 | DundalkDundalk | 1 - 3 | Rapid ViennaRapid Vienna |
| 26 Nov 20 | r04 | LeverkusenLeverkusen | 4 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 26 Nov 20 | r04 | NiceNice | 1 - 3 | Slavia PragueSlavia Prague |
| 26 Nov 20 | r04 | StandardStandard | 2 - 1 | Lech PoznanLech Poznan |
| 26 Nov 20 | r04 | RangersRangers | 2 - 2 | BenficaBenfica |
| 26 Nov 20 | r04 | PSV EindhovenPSV Eindhoven | 3 - 2 | PAOKPAOK |
| 26 Nov 20 | r04 | GranadaGranada | 2 - 1 | Omonia NicosiaOmonia Nicosi |
| 26 Nov 20 | r04 | NapoliNapoli | 2 - 0 | RijekaRijeka |
| 26 Nov 20 | r04 | AZ AlkmaarAZ Alkmaar | 0 - 0 | SociedadSociedad |
| 26 Nov 20 | r04 | TottenhamTottenham | 4 - 0 | Ludogorets RazgradLudogorets Ra |
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