| 18 Aug 20 | Playoff   | EngordanyEngordany | 1 - 3 | ZetaZeta |
| 20 Aug 20 | Playoff | St JosephsSt Josephs | 1 - 2 | B36 TorshavnB36 Torshavn |
| 20 Aug 20 | Playoff | NSI RunavikNSI Runavik | 5 - 1 | Barry Town UnitedBarry Town Un |
| 20 Aug 20 | Playoff | FC Santa ColomaFC Santa Colo | 0 - 0 | Iskra DanilovgradIskra Danilov |
| 20 Aug 20 | Playoff | GlentoranGlentoran | 1 - 0 | HB TorshavnHB Torshavn |
| 20 Aug 20 | Playoff | ColeraineColeraine | 1 - 0 | La FioritaLa Fiorita |
| 21 Aug 20 | Playoff | Tre PenneTre Penne | 1 - 3 | GjilaniGjilani |
| 22 Aug 20 | Playoff | Lincoln Red ImpsLincoln Red I | 3 - 0 | FC PrishtinaFC Prishtina |
| |
| 25 Aug 20 | Qualifier | FK RiteriaiFK Riteriai | 3 - 2 | Derry CityDerry City |
| 26 Aug 20 | Qualifier | Progrès NiederkornProgrès Niede | 3 - 0 | ZetaZeta |
| 27 Aug 20 | Qualifier | Ordabasy ShymkentOrdabasy Shym | 1 - 2 | FC BotoșaniFC Botoșani |
| 27 Aug 20 | Qualifier | FK VentspilsFK Ventspils | 2 - 1 | Dinamo-Auto TiraspolDinamo-Auto T |
| 27 Aug 20 | Qualifier | Kairat AlmatyKairat Almaty | 4 - 1 | NoahNoah |
| 27 Aug 20 | Qualifier | KS Teuta KS Teuta | 2 - 0 | Beitar JerusalemBeitar Jerusa |
| 27 Aug 20 | Qualifier | Borac Banja LukaBorac Banja L | 1 - 0 | SutjeskaSutjeska |
| 27 Aug 20 | Qualifier | Dinamo MinskDinamo Minsk | 0 - 2 | Piast GliwicePiast Gliwice |
| 27 Aug 20 | Qualifier | Lincoln Red ImpsLincoln Red I | 2 - 0 | UT PétangeUT Pétange |
| 27 Aug 20 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 2 - 1 | Víkingur ReykjavikVíkingur Reyk |
| 27 Aug 20 | Qualifier | Neftçi PFKNeftçi PFK | 2 - 1 | ShkupiShkupi |
| 27 Aug 20 | Qualifier | Bodoe/GlimtBodoe/Glimt | 6 - 1 | Kauno ŽalgirisKauno Žalgiri |
| 27 Aug 20 | Qualifier | AlashkertAlashkert | 0 - 1 | RenovaRenova |
| 27 Aug 20 | Qualifier | Apollon LimassolApollon Limas | 5 - 1 | Saburtalo TbilisiSaburtalo Tbi |
| 27 Aug 20 | Qualifier | Sumgayit FKSumgayit FK | 0 - 2 | Shkendija 79Shkendija 79 |
| 27 Aug 20 | Qualifier | Videoton FC FehervarVideoton FC F | 1 - 1 | BohemiansBohemians |
| 27 Aug 20 | Qualifier | HammarbyHammarby | 3 - 0 | Puskás Akadémia FCPuskás Akadém |
| 27 Aug 20 | Qualifier | AGF AarhusAGF Aarhus | 5 - 2 | HonkaHonka |
| 27 Aug 20 | Qualifier | VaduzVaduz | 0 - 2 | Hibernians FCHibernians FC |
| 27 Aug 20 | Qualifier | GjilaniGjilani | 0 - 2 | Apoel NicosiaApoel Nicosia |
| 27 Aug 20 | Qualifier | RosenborgRosenborg | 4 - 2 | BreidablikBreidablik |
| 27 Aug 20 | Qualifier | VMFD ZalgirisVMFD Zalgiris | 2 - 0 | Paide LinnameeskondPaide Linname |
| 27 Aug 20 | Qualifier  | Malmo FFMalmo FF | 2 - 0 | Cracovia KrakowCracovia Krak |
| 27 Aug 20 | Qualifier | Keşla FKKeşla FK | 0 - 0 | LaciLaci |
| 27 Aug 20 | Qualifier | CSKA SofiaCSKA Sofia | 2 - 1 | Sirens FCSirens FC |
| 27 Aug 20 | Qualifier | Locomotive TbilisiLocomotive Tb | 2 - 1 | Universitatea CraiovaUniversitatea |
| 27 Aug 20 | Qualifier | KukesiKukesi | 2 - 1 | Slavia SofiaSlavia Sofia |
| 27 Aug 20 | Qualifier | Petrocub HînceștiPetrocub Hînc | 0 - 2 | TSC Bačka TopolaTSC Bačka Top |
| 27 Aug 20 | Qualifier | FH Hafnarfjordur FH Hafnarfjor | 0 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 27 Aug 20 | Qualifier | TNSTNS | 3 - 1 | MSK ZilinaMSK Zilina |
| 27 Aug 20 | Qualifier | Shakhter SoligorskShakhter Soli | 0 - 0 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 27 Aug 20 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 3 - 0 | Dinamo BatumiDinamo Batumi |
| 27 Aug 20 | Qualifier | B36 TorshavnB36 Torshavn | 4 - 3 | FC Levadia TallinnFC Levadia Ta |
| 27 Aug 20 | Qualifier | Iskra DanilovgradIskra Danilov | 0 - 1 | Lokomotiv Plovdiv Lokomotiv Plo |
| 27 Aug 20 | Qualifier | ZrinjskiZrinjski | 3 - 0 | FC 03 Differdange FC 03 Differd |
| 27 Aug 20 | Qualifier | VallettaValletta | 0 - 1 | BalaBala |
| 27 Aug 20 | Qualifier | Partizan BelgradePartizan Belg | 1 - 0 | Rīgas Futbola SkolaRīgas Futbola |
| 27 Aug 20 | Qualifier | ServetteServette | 3 - 0 | MFK RužomberokMFK Ružombero |
| 27 Aug 20 | Qualifier | Steaua BucurestiSteaua Bucure | 3 - 0 | Shirak GyumriShirak Gyumri |
| 27 Aug 20 | Qualifier | NK MariborNK Maribor | 1 - 1 | ColeraineColeraine |
| 27 Aug 20 | Qualifier | AberdeenAberdeen | 6 - 0 | NSI RunavikNSI Runavik |
| 27 Aug 20 | Qualifier | MotherwellMotherwell | 5 - 1 | GlentoranGlentoran |
| 27 Aug 20 | Qualifier | Kispest HonvedKispest Honve | 2 - 1 | Inter TurkuInter Turku |
| 27 Aug 20 | Qualifier | ShamrockShamrock | 2 - 2 | IlvesIlves |
| 27 Aug 20 | Qualifier | Lech PoznanLech Poznan | 3 - 0 | Valmieras FKValmieras FK |
| 09 Sep 20 | Qualifier | Maccabi HaifaMaccabi Haifa | 3 - 1 | ZeljeznicarZeljeznicar |
| 10 Sep 20 | Qualifier | Nomme KaljuNomme Kalju | 0 - 4 | NŠ MuraNŠ Mura |
| 16 Sep 20 | Qualifier  | Progrès NiederkornProgrès Niede | 0 - 5 | Willem IIWillem II |
| 16 Sep 20 | Qualifier | HammarbyHammarby | 0 - 3 | Lech PoznanLech Poznan |
| 16 Sep 20 | Qualifier | B36 TorshavnB36 Torshavn | 2 - 2 | TNSTNS |
| 17 Sep 20 | Qualifier | Kaisar KyzylordaKaisar Kyzylo | 1 - 4 | Apoel NicosiaApoel Nicosia |
| 17 Sep 20 | Qualifier | FK VentspilsFK Ventspils | 1 - 5 | RosenborgRosenborg |
| 17 Sep 20 | Qualifier | RenovaRenova | 0 - 1 | Hajduk SplitHajduk Split |
| 17 Sep 20 | Qualifier | FC AstanaFC Astana | 0 - 1 | Buducnost PodgoricaBuducnost Pod |
| 17 Sep 20 | Qualifier | KS Teuta KS Teuta | 0 - 4 | GranadaGranada |
| 17 Sep 20 | Qualifier | Ararat-ArmeniaArarat-Armeni | 4 - 3 | FolaFola |
| 17 Sep 20 | Qualifier | Lincoln Red ImpsLincoln Red I | 0 - 5 | RangersRangers |
| 17 Sep 20 | Qualifier | KuPS KuopioKuPS Kuopio | 1 - 1 | Slovan BratislavaSlovan Bratis |
| 17 Sep 20 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 2 - 3 | ZrinjskiZrinjski |
| 17 Sep 20 | Qualifier | FC BotoșaniFC Botoșani | 0 - 1 | Shkendija 79Shkendija 79 |
| 17 Sep 20 | Qualifier | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 2 | TottenhamTottenham |
| 17 Sep 20 | Qualifier | Neftçi PFKNeftçi PFK | 1 - 3 | GalatasarayGalatasaray |
| 17 Sep 20 | Qualifier | IFK GothenburgIFK Gothenbur | 1 - 2 | FC CopenhagenFC Copenhagen |
| 17 Sep 20 | Qualifier | FK RiteriaiFK Riteriai | 1 - 5 | LiberecLiberec |
| 17 Sep 20 | Qualifier | Bodoe/GlimtBodoe/Glimt | 3 - 1 | VMFD ZalgirisVMFD Zalgiris |
| 17 Sep 20 | Qualifier | Sfântul Gheorghe SuruceniSfântul Gheor | 0 - 1 | Partizan BelgradePartizan Belg |
| 17 Sep 20 | Qualifier | FC Flora TallinFC Flora Tall | 2 - 1 | KR ReykjavikKR Reykjavik |
| 17 Sep 20 | Qualifier | Connah's Quay NomadsConnah's Quay | 0 - 1 | Dinamo TbilisiDinamo Tbilis |
| 17 Sep 20 | Qualifier | Locomotive TbilisiLocomotive Tb | 2 - 1 | Dinamo MoscowDinamo Moscow |
| 17 Sep 20 | Qualifier | CSKA SofiaCSKA Sofia | 2 - 0 | BATE BorisovBATE Borisov |
| 17 Sep 20 | Qualifier | LaciLaci | 1 - 2 | Hapoel Beer ShevaHapoel Beer S |
| 17 Sep 20 | Qualifier | Hibernians FCHibernians FC | 0 - 1 | Videoton FC FehervarVideoton FC F |
| 17 Sep 20 | Qualifier | OFIOFI | 0 - 1 | Apollon LimassolApollon Limas |
| 17 Sep 20 | Qualifier | KukesiKukesi | 0 - 4 | WolfsburgWolfsburg |
| 17 Sep 20 | Qualifier | Maccabi HaifaMaccabi Haifa | 2 - 1 | Kairat AlmatyKairat Almaty |
| 17 Sep 20 | Qualifier | Inter Club d'EscaldesInter Club d' | 0 - 1 | DundalkDundalk |
| 17 Sep 20 | Qualifier | ShamrockShamrock | 0 - 2 | MilanMilan |
| 17 Sep 20 | Qualifier | Piast GliwicePiast Gliwice | 3 - 2 | TSV HartbergTSV Hartberg |
| 17 Sep 20 | Qualifier | Borac Banja LukaBorac Banja L | 0 - 2 | Rio AveRio Ave |
| 17 Sep 20 | Qualifier | SileksSileks | 0 - 2 | DritaDrita |
| 17 Sep 20 | Qualifier | StandardStandard | 2 - 0 | BalaBala |
| 17 Sep 20 | Qualifier | ArisAris | 1 - 2 | FC Kolos KovalivkaFC Kolos Kova |
| 17 Sep 20 | Qualifier | NŠ MuraNŠ Mura | 3 - 0 | AGF AarhusAGF Aarhus |
| 17 Sep 20 | Qualifier | ColeraineColeraine | 2 - 2 | MotherwellMotherwell |
| 17 Sep 20 | Qualifier | VikingViking | 0 - 2 | AberdeenAberdeen |
| 17 Sep 20 | Qualifier | ServetteServette | 0 - 1 | Stade de ReimsStade de Reim |
| 17 Sep 20 | Qualifier | OsijekOsijek | 1 - 2 | FC BaselFC Basel |
| 17 Sep 20 | Qualifier | LinfieldLinfield | 0 - 1 | Floriana FCFloriana FC |
| 17 Sep 20 | Qualifier | DAC 1904 Dunajská StredaDAC 1904 Duna | 5 - 3 | JablonecJablonec |
| 17 Sep 20 | Qualifier | TSC Bačka TopolaTSC Bačka Top | 6 - 6 | Steaua BucurestiSteaua Bucure |
| 17 Sep 20 | Qualifier | Kispest HonvedKispest Honve | 0 - 2 | Malmo FFMalmo FF |
| 18 Sep 20 | Qualifier | Riga FCRiga FC | 1 - 0 | Tre FioriTre Fiori |
| 23 Sep 20 | Qualifier | Apollon LimassolApollon Limas | 0 - 5 | Lech PoznanLech Poznan |
| 24 Sep 20 | Qualifier | Ararat-ArmeniaArarat-Armeni | 1 - 0 | CeljeCelje |
| 24 Sep 20 | Qualifier | KuPS KuopioKuPS Kuopio | 2 - 0 | FK Suduva FK Suduva |
| 24 Sep 20 | Qualifier | Viktoria PlzenViktoria Plze | 3 - 0 | SønderjyskeSønderjyske |
| 24 Sep 20 | Qualifier | Videoton FC FehervarVideoton FC F | 0 - 0 | Stade de ReimsStade de Reim |
| 24 Sep 20 | Qualifier | BesiktasBesiktas | 1 - 1 | Rio AveRio Ave |
| 24 Sep 20 | Qualifier | FK RostovFK Rostov | 1 - 2 | Maccabi HaifaMaccabi Haifa |
| 24 Sep 20 | Qualifier | Malmo FFMalmo FF | 5 - 0 | NK LokomotivaNK Lokomotiva |
| 24 Sep 20 | Qualifier | RosenborgRosenborg | 1 - 0 | AlanyasporAlanyaspor |
| 24 Sep 20 | Qualifier | FC CopenhagenFC Copenhagen | 3 - 0 | Piast GliwicePiast Gliwice |
| 24 Sep 20 | Qualifier | CSKA SofiaCSKA Sofia | 3 - 1 | B36 TorshavnB36 Torshavn |
| 24 Sep 20 | Qualifier | DjurgaardenDjurgaarden | 0 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 24 Sep 20 | Qualifier | Floriana FCFloriana FC | 0 - 0 | FC Flora TallinFC Flora Tall |
| 24 Sep 20 | Qualifier | CharleroiCharleroi | 2 - 1 | Partizan BelgradePartizan Belg |
| 24 Sep 20 | Qualifier | NŠ MuraNŠ Mura | 1 - 5 | PSV EindhovenPSV Eindhoven |
| 24 Sep 20 | Qualifier | Riga FCRiga FC | 0 - 1 | CelticCeltic |
| 24 Sep 20 | Qualifier | Steaua BucurestiSteaua Bucure | 0 - 2 | LiberecLiberec |
| 24 Sep 20 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 3 - 0 | MotherwellMotherwell |
| 24 Sep 20 | Qualifier | Shkendija 79Shkendija 79 | 1 - 3 | TottenhamTottenham |
| 24 Sep 20 | Qualifier | GranadaGranada | 2 - 0 | Locomotive TbilisiLocomotive Tb |
| 24 Sep 20 | Qualifier | StandardStandard | 2 - 1 | VojvodinaVojvodina |
| 24 Sep 20 | Qualifier | GalatasarayGalatasaray | 2 - 0 | Hajduk SplitHajduk Split |
| 24 Sep 20 | Qualifier | Apoel NicosiaApoel Nicosia | 2 - 2 | ZrinjskiZrinjski |
| 24 Sep 20 | Qualifier | Sheriff TiraspolSheriff Tiras | 1 - 1 | DundalkDundalk |
| 24 Sep 20 | Qualifier | FK SarajevoFK Sarajevo | 2 - 1 | Buducnost PodgoricaBuducnost Pod |
| 24 Sep 20 | Qualifier | KÍ KlaksvíkKÍ Klaksvík | 6 - 1 | Dinamo TbilisiDinamo Tbilis |
| 24 Sep 20 | Qualifier | WolfsburgWolfsburg | 2 - 0 | DesnaDesna |
| 24 Sep 20 | Qualifier | St. GallenSt. Gallen | 0 - 1 | AEKAEK |
| 24 Sep 20 | Qualifier | MilanMilan | 3 - 2 | Bodoe/GlimtBodoe/Glimt |
| 24 Sep 20 | Qualifier | FC BaselFC Basel | 3 - 2 | Anorthosis FamagustaAnorthosis Fa |
| 24 Sep 20 | Qualifier | LASKLASK | 7 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 24 Sep 20 | Qualifier | Legia WarsawLegia Warsaw | 2 - 0 | DritaDrita |
| 24 Sep 20 | Qualifier | RijekaRijeka | 2 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 24 Sep 20 | Qualifier | Willem IIWillem II | 0 - 4 | RangersRangers |
| 24 Sep 20 | Qualifier | Sporting CPSporting CP | 1 - 0 | AberdeenAberdeen |
| |
| 01 Oct 20 | Playoff | CFR Cluj-NapocaCFR Cluj-Napo | 3 - 1 | KuPS KuopioKuPS Kuopio |
| 01 Oct 20 | Playoff | Ararat-ArmeniaArarat-Armeni | 1 - 2 | Crvena ZvezdaCrvena Zvezda |
| 01 Oct 20 | Playoff | RosenborgRosenborg | 0 - 2 | PSV EindhovenPSV Eindhoven |
| 01 Oct 20 | Playoff | CharleroiCharleroi | 1 - 2 | Lech PoznanLech Poznan |
| 01 Oct 20 | Playoff | Malmo FFMalmo FF | 1 - 3 | GranadaGranada |
| 01 Oct 20 | Playoff | LiberecLiberec | 1 - 0 | Apoel NicosiaApoel Nicosia |
| 01 Oct 20 | Playoff | Dinamo ZagrebDinamo Zagreb | 3 - 1 | FC Flora TallinFC Flora Tall |
| 01 Oct 20 | Playoff | FC CopenhagenFC Copenhagen | 0 - 1 | RijekaRijeka |
| 01 Oct 20 | Playoff | Young BoysYoung Boys | 3 - 0 | SK TiranaSK Tirana |
| 01 Oct 20 | Playoff | Hapoel Beer ShevaHapoel Beer S | 1 - 0 | Viktoria PlzenViktoria Plze |
| 01 Oct 20 | Playoff | Dynamo BrestDynamo Brest | 0 - 2 | Ludogorets RazgradLudogorets Ra |
| 01 Oct 20 | Playoff | FK SarajevoFK Sarajevo | 0 - 1 | CelticCeltic |
| 01 Oct 20 | Playoff | Legia WarsawLegia Warsaw | 0 - 3 | Qarabag FKQarabag FK |
| 01 Oct 20 | Playoff | StandardStandard | 3 - 1 | Videoton FC FehervarVideoton FC F |
| 01 Oct 20 | Playoff | FC BaselFC Basel | 1 - 3 | CSKA SofiaCSKA Sofia |
| 01 Oct 20 | Playoff | DundalkDundalk | 3 - 1 | KÍ KlaksvíkKÍ Klaksvík |
| 01 Oct 20 | Playoff | AEKAEK | 2 - 1 | WolfsburgWolfsburg |
| 01 Oct 20 | Playoff | RangersRangers | 2 - 1 | GalatasarayGalatasaray |
| 01 Oct 20 | Playoff | Sporting CPSporting CP | 1 - 4 | LASKLASK |
| 01 Oct 20 | Playoff | Rio AveRio Ave | 2 - 2 | MilanMilan |
| 01 Oct 20 | Playoff  | TottenhamTottenham | 7 - 2 | Maccabi HaifaMaccabi Haifa |
| |
| 22 Oct 20 | r01 | Young BoysYoung Boys | 1 - 2 | RomaRoma |
| 22 Oct 20 | r01 | CSKA SofiaCSKA Sofia | 0 - 2 | CFR Cluj-NapocaCFR Cluj-Napo |
| 22 Oct 20 | r01 | RijekaRijeka | 0 - 1 | SociedadSociedad |
| 22 Oct 20 | r01 | NapoliNapoli | 0 - 1 | AZ AlkmaarAZ Alkmaar |
| 22 Oct 20 | r01 | DundalkDundalk | 1 - 2 | MoldeMolde |
| 22 Oct 20 | r01 | Rapid ViennaRapid Vienna | 1 - 2 | ArsenalArsenal |
| 22 Oct 20 | r01 | LeverkusenLeverkusen | 6 - 2 | NiceNice |
| 22 Oct 20 | r01 | Hapoel Beer ShevaHapoel Beer S | 3 - 1 | Slavia PragueSlavia Prague |
| 22 Oct 20 | r01 | StandardStandard | 0 - 2 | RangersRangers |
| 22 Oct 20 | r01 | Lech PoznanLech Poznan | 2 - 4 | BenficaBenfica |
| 22 Oct 20 | r01 | PSV EindhovenPSV Eindhoven | 1 - 2 | GranadaGranada |
| 22 Oct 20 | r01 | PAOKPAOK | 1 - 1 | Omonia NicosiaOmonia Nicosi |
| 22 Oct 20 | r01 | LiberecLiberec | 1 - 0 | GentGent |
| 22 Oct 20 | r01 | HoffenheimHoffenheim | 2 - 0 | Crvena ZvezdaCrvena Zvezda |
| 22 Oct 20 | r01 | Wolfsberger ACWolfsberger A | 1 - 1 | CSKA MoscowCSKA Moscow |
| 22 Oct 20 | r01 | Dinamo ZagrebDinamo Zagreb | 0 - 0 | FeyenoordFeyenoord |
| 22 Oct 20 | r01 | Ludogorets RazgradLudogorets Ra | 1 - 2 | AntwerpAntwerp |
| 22 Oct 20 | r01 | TottenhamTottenham | 3 - 0 | LASKLASK |
| 22 Oct 20 | r01 | VillarrealVillarreal | 5 - 3 | SivassporSivasspor |
| 22 Oct 20 | r01 | Maccabi Tel AvivMaccabi Tel A | 1 - 0 | Qarabag FKQarabag FK |
| 22 Oct 20 | r01 | CelticCeltic | 1 - 3 | MilanMilan |
| 22 Oct 20 | r01 | Sparta PragueSparta Prague | 1 - 4 | LilleLille |
| 22 Oct 20 | r01 | LeicesterLeicester | 3 - 0 | ZoryaZorya |
| 22 Oct 20 | r01 | BragaBraga | 3 - 0 | AEKAEK |
| |
| 29 Oct 20 | r02 | AEKAEK | 1 - 2 | LeicesterLeicester |
| 29 Oct 20 | r02 | ZoryaZorya | 1 - 2 | BragaBraga |
| 29 Oct 20 | r02 | MilanMilan | 3 - 0 | Sparta PragueSparta Prague |
| 29 Oct 20 | r02 | LilleLille | 2 - 2 | CelticCeltic |
| 29 Oct 20 | r02 | Qarabag FKQarabag FK | 1 - 3 | VillarrealVillarreal |
| 29 Oct 20 | r02 | SivassporSivasspor | 1 - 2 | Maccabi Tel AvivMaccabi Tel A |
| 29 Oct 20 | r02 | LASKLASK | 4 - 3 | Ludogorets RazgradLudogorets Ra |
| 29 Oct 20 | r02 | AntwerpAntwerp | 1 - 0 | TottenhamTottenham |
| 29 Oct 20 | r02 | CSKA MoscowCSKA Moscow | 0 - 0 | Dinamo ZagrebDinamo Zagreb |
| 29 Oct 20 | r02 | FeyenoordFeyenoord | 1 - 4 | Wolfsberger ACWolfsberger A |
| 29 Oct 20 | r02 | Crvena ZvezdaCrvena Zvezda | 5 - 1 | LiberecLiberec |
| 29 Oct 20 | r02 | GentGent | 1 - 4 | HoffenheimHoffenheim |
| 29 Oct 20 | r02 | RomaRoma | 0 - 0 | CSKA SofiaCSKA Sofia |
| 29 Oct 20 | r02 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 1 | Young BoysYoung Boys |
| 29 Oct 20 | r02 | ArsenalArsenal | 3 - 0 | DundalkDundalk |
| 29 Oct 20 | r02 | MoldeMolde | 1 - 0 | Rapid ViennaRapid Vienna |
| 29 Oct 20 | r02 | Slavia PragueSlavia Prague | 1 - 0 | LeverkusenLeverkusen |
| 29 Oct 20 | r02 | NiceNice | 1 - 0 | Hapoel Beer ShevaHapoel Beer S |
| 29 Oct 20 | r02 | BenficaBenfica | 3 - 0 | StandardStandard |
| 29 Oct 20 | r02 | RangersRangers | 1 - 0 | Lech PoznanLech Poznan |
| 29 Oct 20 | r02 | GranadaGranada | 0 - 0 | PAOKPAOK |
| 29 Oct 20 | r02 | Omonia NicosiaOmonia Nicosi | 1 - 2 | PSV EindhovenPSV Eindhoven |
| 29 Oct 20 | r02 | AZ AlkmaarAZ Alkmaar | 4 - 1 | RijekaRijeka |
| 29 Oct 20 | r02 | SociedadSociedad | 0 - 1 | NapoliNapoli |
| |
| 05 Nov 20 | r03 | RomaRoma | 5 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 05 Nov 20 | r03 | Rapid ViennaRapid Vienna | 4 - 3 | DundalkDundalk |
| 05 Nov 20 | r03 | Slavia PragueSlavia Prague | 3 - 2 | NiceNice |
| 05 Nov 20 | r03 | Hapoel Beer ShevaHapoel Beer S | 2 - 4 | LeverkusenLeverkusen |
| 05 Nov 20 | r03 | BenficaBenfica | 3 - 3 | RangersRangers |
| 05 Nov 20 | r03 | Lech PoznanLech Poznan | 3 - 1 | StandardStandard |
| 05 Nov 20 | r03 | PAOKPAOK | 4 - 1 | PSV EindhovenPSV Eindhoven |
| 05 Nov 20 | r03 | Omonia NicosiaOmonia Nicosi | 0 - 2 | GranadaGranada |
| 05 Nov 20 | r03 | RijekaRijeka | 1 - 2 | NapoliNapoli |
| 05 Nov 20 | r03 | SociedadSociedad | 1 - 0 | AZ AlkmaarAZ Alkmaar |
| 05 Nov 20 | r03 | SivassporSivasspor | 2 - 0 | Qarabag FKQarabag FK |
| 05 Nov 20 | r03 | Ludogorets RazgradLudogorets Ra | 1 - 3 | TottenhamTottenham |
| 05 Nov 20 | r03 | Young BoysYoung Boys | 3 - 0 | CSKA SofiaCSKA Sofia |
| 05 Nov 20 | r03 | ArsenalArsenal | 4 - 1 | MoldeMolde |
| 05 Nov 20 | r03 | LeicesterLeicester | 4 - 0 | BragaBraga |
| 05 Nov 20 | r03 | ZoryaZorya | 1 - 4 | AEKAEK |
| 05 Nov 20 | r03 | CelticCeltic | 1 - 4 | Sparta PragueSparta Prague |
| 05 Nov 20 | r03 | MilanMilan | 0 - 3 | LilleLille |
| 05 Nov 20 | r03 | AntwerpAntwerp | 0 - 1 | LASKLASK |
| 05 Nov 20 | r03 | Dinamo ZagrebDinamo Zagreb | 1 - 0 | Wolfsberger ACWolfsberger A |
| 05 Nov 20 | r03 | FeyenoordFeyenoord | 3 - 1 | CSKA MoscowCSKA Moscow |
| 05 Nov 20 | r03 | Crvena ZvezdaCrvena Zvezda | 2 - 1 | GentGent |
| 05 Nov 20 | r03 | HoffenheimHoffenheim | 5 - 0 | LiberecLiberec |
| 05 Nov 20 | r03 | VillarrealVillarreal | 4 - 0 | Maccabi Tel AvivMaccabi Tel A |
| |
| 26 Nov 20 | r04 | CSKA SofiaCSKA Sofia | 0 - 1 | Young BoysYoung Boys |
| 26 Nov 20 | r04 | MoldeMolde | 0 - 3 | ArsenalArsenal |
| 26 Nov 20 | r04 | BragaBraga | 3 - 3 | LeicesterLeicester |
| 26 Nov 20 | r04 | AEKAEK | 0 - 3 | ZoryaZorya |
| 26 Nov 20 | r04 | Sparta PragueSparta Prague | 4 - 1 | CelticCeltic |
| 26 Nov 20 | r04 | LilleLille | 1 - 1 | MilanMilan |
| 26 Nov 20 | r04 | Maccabi Tel AvivMaccabi Tel A | 1 - 1 | VillarrealVillarreal |
| 26 Nov 20 | r04 | Qarabag FKQarabag FK | 2 - 3 | SivassporSivasspor |
| 26 Nov 20 | r04 | LASKLASK | 0 - 2 | AntwerpAntwerp |
| 26 Nov 20 | r04 | CSKA MoscowCSKA Moscow | 0 - 0 | FeyenoordFeyenoord |
| 26 Nov 20 | r04 | Wolfsberger ACWolfsberger A | 0 - 3 | Dinamo ZagrebDinamo Zagreb |
| 26 Nov 20 | r04 | GentGent | 0 - 2 | Crvena ZvezdaCrvena Zvezda |
| 26 Nov 20 | r04 | LiberecLiberec | 0 - 2 | HoffenheimHoffenheim |
| 26 Nov 20 | r04 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 2 | RomaRoma |
| 26 Nov 20 | r04 | DundalkDundalk | 1 - 3 | Rapid ViennaRapid Vienna |
| 26 Nov 20 | r04 | LeverkusenLeverkusen | 4 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 26 Nov 20 | r04 | NiceNice | 1 - 3 | Slavia PragueSlavia Prague |
| 26 Nov 20 | r04 | StandardStandard | 2 - 1 | Lech PoznanLech Poznan |
| 26 Nov 20 | r04 | RangersRangers | 2 - 2 | BenficaBenfica |
| 26 Nov 20 | r04 | PSV EindhovenPSV Eindhoven | 3 - 2 | PAOKPAOK |
| 26 Nov 20 | r04 | GranadaGranada | 2 - 1 | Omonia NicosiaOmonia Nicosi |
| 26 Nov 20 | r04 | NapoliNapoli | 2 - 0 | RijekaRijeka |
| 26 Nov 20 | r04 | AZ AlkmaarAZ Alkmaar | 0 - 0 | SociedadSociedad |
| 26 Nov 20 | r04 | TottenhamTottenham | 4 - 0 | Ludogorets RazgradLudogorets Ra |
| |
| 03 Dec 20 | r05 | AEKAEK | 2 - 4 | BragaBraga |
| 03 Dec 20 | r05 | ZoryaZorya | 1 - 0 | LeicesterLeicester |
| 03 Dec 20 | r05 | MilanMilan | 4 - 2 | CelticCeltic |
| 03 Dec 20 | r05 | LilleLille | 2 - 1 | Sparta PragueSparta Prague |
| 03 Dec 20 | r05 | Qarabag FKQarabag FK | 1 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 03 Dec 20 | r05 | SivassporSivasspor | 0 - 1 | VillarrealVillarreal |
| 03 Dec 20 | r05 | LASKLASK | 3 - 3 | TottenhamTottenham |
| 03 Dec 20 | r05 | AntwerpAntwerp | 3 - 1 | Ludogorets RazgradLudogorets Ra |
| 03 Dec 20 | r05 | CSKA MoscowCSKA Moscow | 0 - 1 | Wolfsberger ACWolfsberger A |
| 03 Dec 20 | r05 | FeyenoordFeyenoord | 0 - 2 | Dinamo ZagrebDinamo Zagreb |
| 03 Dec 20 | r05 | Crvena ZvezdaCrvena Zvezda | 0 - 0 | HoffenheimHoffenheim |
| 03 Dec 20 | r05 | GentGent | 1 - 2 | LiberecLiberec |
| 03 Dec 20 | r05 | RomaRoma | 3 - 1 | Young BoysYoung Boys |
| 03 Dec 20 | r05 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 0 | CSKA SofiaCSKA Sofia |
| 03 Dec 20 | r05 | ArsenalArsenal | 4 - 1 | Rapid ViennaRapid Vienna |
| 03 Dec 20 | r05 | MoldeMolde | 3 - 1 | DundalkDundalk |
| 03 Dec 20 | r05 | Slavia PragueSlavia Prague | 3 - 0 | Hapoel Beer ShevaHapoel Beer S |
| 03 Dec 20 | r05 | NiceNice | 2 - 3 | LeverkusenLeverkusen |
| 03 Dec 20 | r05 | BenficaBenfica | 4 - 0 | Lech PoznanLech Poznan |
| 03 Dec 20 | r05 | RangersRangers | 3 - 2 | StandardStandard |
| 03 Dec 20 | r05 | Omonia NicosiaOmonia Nicosi | 2 - 1 | PAOKPAOK |
| 03 Dec 20 | r05 | GranadaGranada | 0 - 1 | PSV EindhovenPSV Eindhoven |
| 03 Dec 20 | r05 | AZ AlkmaarAZ Alkmaar | 1 - 1 | NapoliNapoli |
| 03 Dec 20 | r05 | SociedadSociedad | 2 - 2 | RijekaRijeka |
| |
| 10 Dec 20 | r06 | Young BoysYoung Boys | 2 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 10 Dec 20 | r06 | CSKA SofiaCSKA Sofia | 3 - 1 | RomaRoma |
| 10 Dec 20 | r06 | DundalkDundalk | 2 - 4 | ArsenalArsenal |
| 10 Dec 20 | r06 | Rapid ViennaRapid Vienna | 2 - 2 | MoldeMolde |
| 10 Dec 20 | r06 | LeverkusenLeverkusen | 4 - 0 | Slavia PragueSlavia Prague |
| 10 Dec 20 | r06 | Hapoel Beer ShevaHapoel Beer S | 1 - 0 | NiceNice |
| 10 Dec 20 | r06 | StandardStandard | 2 - 2 | BenficaBenfica |
| 10 Dec 20 | r06 | Lech PoznanLech Poznan | 0 - 2 | RangersRangers |
| 10 Dec 20 | r06 | PSV EindhovenPSV Eindhoven | 4 - 0 | Omonia NicosiaOmonia Nicosi |
| 10 Dec 20 | r06 | PAOKPAOK | 0 - 0 | GranadaGranada |
| 10 Dec 20 | r06 | NapoliNapoli | 1 - 1 | SociedadSociedad |
| 10 Dec 20 | r06 | RijekaRijeka | 2 - 1 | AZ AlkmaarAZ Alkmaar |
| 10 Dec 20 | r06 | BragaBraga | 2 - 0 | ZoryaZorya |
| 10 Dec 20 | r06 | LeicesterLeicester | 2 - 0 | AEKAEK |
| 10 Dec 20 | r06 | CelticCeltic | 3 - 2 | LilleLille |
| 10 Dec 20 | r06 | Sparta PragueSparta Prague | 0 - 1 | MilanMilan |
| 10 Dec 20 | r06 | Maccabi Tel AvivMaccabi Tel A | 1 - 0 | SivassporSivasspor |
| 10 Dec 20 | r06 | VillarrealVillarreal | 3 - 0 | Qarabag FKQarabag FK |
| 10 Dec 20 | r06 | TottenhamTottenham | 2 - 0 | AntwerpAntwerp |
| 10 Dec 20 | r06 | Ludogorets RazgradLudogorets Ra | 1 - 3 | LASKLASK |
| 10 Dec 20 | r06 | Dinamo ZagrebDinamo Zagreb | 3 - 1 | CSKA MoscowCSKA Moscow |
| 10 Dec 20 | r06 | Wolfsberger ACWolfsberger A | 1 - 0 | FeyenoordFeyenoord |
| 10 Dec 20 | r06 | HoffenheimHoffenheim | 4 - 1 | GentGent |
| 10 Dec 20 | r06 | LiberecLiberec | 0 - 0 | Crvena ZvezdaCrvena Zvezda |
| |
| 18 Feb 21 | r32 | Dynamo KievDynamo Kiev | 1 - 1 | Club BruggeClub Brugge |
| 18 Feb 21 | r32 | Wolfsberger ACWolfsberger A | 1 - 4 | TottenhamTottenham |
| 18 Feb 21 | r32 | SociedadSociedad | 0 - 4 | Manchester UnitedManchester Un |
| 18 Feb 21 | r32 | Crvena ZvezdaCrvena Zvezda | 2 - 2 | MilanMilan |
| 18 Feb 21 | r32 | Slavia PragueSlavia Prague | 0 - 0 | LeicesterLeicester |
| 18 Feb 21 | r32 | BragaBraga | 0 - 2 | RomaRoma |
| 18 Feb 21 | r32 | FC KrasnodarFC Krasnodar | 2 - 3 | Dinamo ZagrebDinamo Zagreb |
| 18 Feb 21 | r32 | Young BoysYoung Boys | 4 - 3 | LeverkusenLeverkusen |
| 18 Feb 21 | r32 | OlympiakosOlympiakos | 4 - 2 | PSV EindhovenPSV Eindhoven |
| 18 Feb 21 | r32 | BenficaBenfica | 1 - 1 | ArsenalArsenal |
| 18 Feb 21 | r32 | AntwerpAntwerp | 3 - 4 | RangersRangers |
| 18 Feb 21 | r32 | SV SalzburgSV Salzburg | 0 - 2 | VillarrealVillarreal |
| 18 Feb 21 | r32 | MoldeMolde | 3 - 3 | HoffenheimHoffenheim |
| 18 Feb 21 | r32 | GranadaGranada | 2 - 0 | NapoliNapoli |
| 18 Feb 21 | r32 | Maccabi Tel AvivMaccabi Tel A | 0 - 2 | Shakhtar DonetskShakhtar Done |
| 18 Feb 21 | r32 | LilleLille | 1 - 2 | AjaxAjax |
| 24 Feb 21 | r32 | TottenhamTottenham | 4 - 0 | Wolfsberger ACWolfsberger A |
| 25 Feb 21 | r32 | ArsenalArsenal | 3 - 2 | BenficaBenfica |
| 25 Feb 21 | r32 | RangersRangers | 5 - 2 | AntwerpAntwerp |
| 25 Feb 21 | r32 | VillarrealVillarreal | 2 - 1 | SV SalzburgSV Salzburg |
| 25 Feb 21 | r32 | HoffenheimHoffenheim | 0 - 2 | MoldeMolde |
| 25 Feb 21 | r32 | NapoliNapoli | 2 - 1 | GranadaGranada |
| 25 Feb 21 | r32 | Shakhtar DonetskShakhtar Done | 1 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 25 Feb 21 | r32 | AjaxAjax | 2 - 1 | LilleLille |
| 25 Feb 21 | r32 | Club BruggeClub Brugge | 0 - 1 | Dynamo KievDynamo Kiev |
| 25 Feb 21 | r32 | Manchester UnitedManchester Un | 0 - 0 | SociedadSociedad |
| 25 Feb 21 | r32 | MilanMilan | 1 - 1 | Crvena ZvezdaCrvena Zvezda |
| 25 Feb 21 | r32 | LeicesterLeicester | 0 - 2 | Slavia PragueSlavia Prague |
| 25 Feb 21 | r32 | RomaRoma | 3 - 1 | BragaBraga |
| 25 Feb 21 | r32 | Dinamo ZagrebDinamo Zagreb | 1 - 0 | FC KrasnodarFC Krasnodar |
| 25 Feb 21 | r32 | LeverkusenLeverkusen | 0 - 2 | Young BoysYoung Boys |
| 25 Feb 21 | r32 | PSV EindhovenPSV Eindhoven | 2 - 1 | OlympiakosOlympiakos |
| |
| 11 Mar 21 | r16 | AjaxAjax | 3 - 0 | Young BoysYoung Boys |
| 11 Mar 21 | r16 | Dynamo KievDynamo Kiev | 0 - 2 | VillarrealVillarreal |
| 11 Mar 21 | r16 | Manchester UnitedManchester Un | 1 - 1 | MilanMilan |
| 11 Mar 21 | r16 | Slavia PragueSlavia Prague | 1 - 1 | RangersRangers |
| 11 Mar 21 | r16 | RomaRoma | 3 - 0 | Shakhtar DonetskShakhtar Done |
| 11 Mar 21 | r16 | OlympiakosOlympiakos | 1 - 3 | ArsenalArsenal |
| 11 Mar 21 | r16 | GranadaGranada | 2 - 0 | MoldeMolde |
| 11 Mar 21 | r16 | TottenhamTottenham | 2 - 0 | Dinamo ZagrebDinamo Zagreb |
| 18 Mar 21 | r16 | Dinamo ZagrebDinamo Zagreb | 3 - 0 | TottenhamTottenham |
| 18 Mar 21 | r16 | Shakhtar DonetskShakhtar Done | 1 - 2 | RomaRoma |
| 18 Mar 21 | r16 | ArsenalArsenal | 0 - 1 | OlympiakosOlympiakos |
| 18 Mar 21 | r16 | MoldeMolde | 2 - 1 | GranadaGranada |
| 18 Mar 21 | r16 | Young BoysYoung Boys | 0 - 2 | AjaxAjax |
| 18 Mar 21 | r16 | VillarrealVillarreal | 2 - 0 | Dynamo KievDynamo Kiev |
| 18 Mar 21 | r16 | MilanMilan | 0 - 1 | Manchester UnitedManchester Un |
| 18 Mar 21 | r16 | RangersRangers | 0 - 2 | Slavia PragueSlavia Prague |
| |
| 08 Apr 21 | QF | GranadaGranada | 0 - 2 | Manchester UnitedManchester Un |
| 08 Apr 21 | QF | ArsenalArsenal | 1 - 1 | Slavia PragueSlavia Prague |
| 08 Apr 21 | QF | AjaxAjax | 1 - 2 | RomaRoma |
| 08 Apr 21 | QF | Dinamo ZagrebDinamo Zagreb | 0 - 1 | VillarrealVillarreal |
| 15 Apr 21 | QF | Manchester UnitedManchester Un | 2 - 0 | GranadaGranada |
| 15 Apr 21 | QF | Slavia PragueSlavia Prague | 0 - 4 | ArsenalArsenal |
| 15 Apr 21 | QF | RomaRoma | 1 - 1 | AjaxAjax |
| 15 Apr 21 | QF | VillarrealVillarreal | 2 - 1 | Dinamo ZagrebDinamo Zagreb |
| |
| 29 Apr 21 | SF | VillarrealVillarreal | 2 - 1 | ArsenalArsenal |
| 29 Apr 21 | SF | Manchester UnitedManchester Un | 6 - 2 | RomaRoma |
| 06 May 21 | SF | ArsenalArsenal | 0 - 0 | VillarrealVillarreal |
| 06 May 21 | SF | RomaRoma | 3 - 2 | Manchester UnitedManchester Un |
| |
| 26 May 21 | Final  | VillarrealVillarreal | 1 - 1 | Manchester UnitedManchester Un |
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