| 08 Nov 18 | r04  | Ludogorets Razgrad Ludogorets Ra | 0 - 0 | AEK LarnacaAEK Larnaca |
| 08 Nov 18 | r04  | FenerbahceFenerbahce | 2 - 0 | AnderlechtAnderlecht |
| 08 Nov 18 | r04 | FC AstanaFC Astana | 2 - 1 | JablonecJablonec |
| 08 Nov 18 | r04 | Rapid ViennaRapid Vienna | 0 - 0 | VillarrealVillarreal |
| 08 Nov 18 | r04 | LazioLazio | 2 - 1 | MarseilleMarseille |
| 08 Nov 18 | r04 | Apollon LimassolApollon Limas | 2 - 3 | Ein FrankfurtEin Frankfurt |
| 08 Nov 18 | r04 | GenkGenk | 1 - 1 | BesiktasBesiktas |
| 08 Nov 18 | r04 | Malmo FFMalmo FF | 1 - 1 | Sarpsborg 08Sarpsborg 08 |
| 08 Nov 18 | r04 | Akhisar BelediyesporAkhisar Beled | 2 - 3 | SevillaSevilla |
| 08 Nov 18 | r04 | FC KrasnodarFC Krasnodar | 2 - 1 | StandardStandard |
| 08 Nov 18 | r04 | Dynamo KievDynamo Kiev | 3 - 1 | RennesRennes |
| 08 Nov 18 | r04 | Videoton FC FehervarVideoton FC F | 1 - 0 | PAOKPAOK |
| 08 Nov 18 | r04 | BATE BorisovBATE Borisov | 0 - 1 | ChelseaChelsea |
| 08 Nov 18 | r04 | LeverkusenLeverkusen | 1 - 0 | ZurichZurich |
| 08 Nov 18 | r04 | CelticCeltic | 2 - 1 | RasenBallsport LeipzigRasenBallspor |
| 08 Nov 18 | r04 | RosenborgRosenborg | 2 - 5 | SV SalzburgSV Salzburg |
| 08 Nov 18 | r04 | Slavia PragueSlavia Prague | 0 - 0 | FC CopenhagenFC Copenhagen |
| 08 Nov 18 | r04 | BordeauxBordeaux | 1 - 1 | Zenit St PetersburgZenit St Pete |
| 08 Nov 18 | r04 | Dinamo ZagrebDinamo Zagreb | 3 - 1 | FC Spartak TrnavaFC Spartak Tr |
| 08 Nov 18 | r04 | ArsenalArsenal | 0 - 0 | Sporting CPSporting CP |
| 08 Nov 18 | r04 | VorsklaVorskla | 0 - 1 | Qarabag FKQarabag FK |
| 08 Nov 18 | r04 | OlympiakosOlympiakos | 5 - 1 | F91 DudelangeF91 Dudelange |
| 08 Nov 18 | r04  | BetisBetis | 1 - 1 | MilanMilan |
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