| 22 Jun 21 | Playoff SF        | HB TorshavnHB Torshavn | 0 - 1 | Inter Club d'EscaldesInter Club d' |
| 22 Jun 21 | Playoff SF        | FolgoreFolgore | 0 - 2 | FC PrishtinaFC Prishtina |
| |
| 25 Jun 21 | Playoff Final        | FC PrishtinaFC Prishtina | 2 - 0 | Inter Club d'EscaldesInter Club d' |
| |
| 06 Jul 21 | Qualifier        | HJK HelsinkiHJK Helsinki | 3 - 1 | Buducnost PodgoricaBuducnost Pod |
| 06 Jul 21 | Qualifier        | FC Flora TallinFC Flora Tall | 2 - 0 | Hibernians FCHibernians FC |
| 06 Jul 21 | Qualifier        | FerencvarosFerencvaros | 3 - 0 | FC PrishtinaFC Prishtina |
| 06 Jul 21 | Qualifier        | CFR Cluj-NapocaCFR Cluj-Napo | 3 - 1 | Borac Banja LukaBorac Banja L |
| 06 Jul 21 | Qualifier        | VMFD ZalgirisVMFD Zalgiris | 3 - 1 | LinfieldLinfield |
| 06 Jul 21 | Qualifier        | FolaFola | 2 - 2 | Lincoln Red ImpsLincoln Red I |
| 06 Jul 21 | Qualifier        | Shkendija 79Shkendija 79 | 0 - 1 | NŠ MuraNŠ Mura |
| 07 Jul 21 | Qualifier        | Slovan BratislavaSlovan Bratis | 2 - 0 | ShamrockShamrock |
| 07 Jul 21 | Qualifier        | Dinamo TbilisiDinamo Tbilis | 1 - 2 | Neftçi PFKNeftçi PFK |
| 07 Jul 21 | Qualifier        | Bodoe/GlimtBodoe/Glimt | 2 - 3 | Legia WarsawLegia Warsaw |
| 07 Jul 21 | Qualifier        | KS Teuta KS Teuta | 0 - 4 | Sheriff TiraspolSheriff Tiras |
| 07 Jul 21 | Qualifier        | Maccabi HaifaMaccabi Haifa | 1 - 1 | Kairat AlmatyKairat Almaty |
| 07 Jul 21 | Qualifier        | Ludogorets RazgradLudogorets Ra | 1 - 0 | Shakhter SoligorskShakhter Soli |
| 07 Jul 21 | Qualifier        | Malmo FFMalmo FF | 1 - 0 | Riga FCRiga FC |
| 07 Jul 21 | Qualifier        | Dinamo ZagrebDinamo Zagreb | 3 - 2 | ValurValur |
| 07 Jul 21 | Qualifier        | Connah's Quay NomadsConnah's Quay | 2 - 2 | AlashkertAlashkert |
| 13 Jul 21 | Qualifier        | Hibernians FCHibernians FC | 0 - 3 | FC Flora TallinFC Flora Tall |
| 13 Jul 21 | Qualifier        | Lincoln Red ImpsLincoln Red I | 5 - 0 | FolaFola |
| 13 Jul 21 | Qualifier        | Riga FCRiga FC | 1 - 1 | Malmo FFMalmo FF |
| 13 Jul 21 | Qualifier        | Sheriff TiraspolSheriff Tiras | 1 - 0 | KS Teuta KS Teuta |
| 13 Jul 21 | Qualifier        | NŠ MuraNŠ Mura | 5 - 0 | Shkendija 79Shkendija 79 |
| 13 Jul 21 | Qualifier        | Borac Banja LukaBorac Banja L | 2 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 13 Jul 21 | Qualifier        | FC PrishtinaFC Prishtina | 1 - 3 | FerencvarosFerencvaros |
| 13 Jul 21 | Qualifier        | Buducnost PodgoricaBuducnost Pod | 0 - 4 | HJK HelsinkiHJK Helsinki |
| 13 Jul 21 | Qualifier        | LinfieldLinfield | 1 - 2 | VMFD ZalgirisVMFD Zalgiris |
| 13 Jul 21 | Qualifier        | ShamrockShamrock | 2 - 1 | Slovan BratislavaSlovan Bratis |
| 13 Jul 21 | Qualifier        | Shakhter SoligorskShakhter Soli | 0 - 1 | Ludogorets RazgradLudogorets Ra |
| 13 Jul 21 | Qualifier        | ValurValur | 0 - 2 | Dinamo ZagrebDinamo Zagreb |
| 14 Jul 21 | Qualifier        | Kairat AlmatyKairat Almaty | 2 - 0 | Maccabi HaifaMaccabi Haifa |
| 14 Jul 21 | Qualifier        | AlashkertAlashkert | 1 - 0 | Connah's Quay NomadsConnah's Quay |
| 14 Jul 21 | Qualifier        | Neftçi PFKNeftçi PFK | 2 - 1 | Dinamo TbilisiDinamo Tbilis |
| 14 Jul 21 | Qualifier        | Legia WarsawLegia Warsaw | 2 - 0 | Bodoe/GlimtBodoe/Glimt |
| 20 Jul 21 | Qualifier        | AlashkertAlashkert | 0 - 1 | Sheriff TiraspolSheriff Tiras |
| 20 Jul 21 | Qualifier        | Lincoln Red ImpsLincoln Red I | 1 - 2 | CFR Cluj-NapocaCFR Cluj-Napo |
| 20 Jul 21 | Qualifier        | FerencvarosFerencvaros | 2 - 0 | VMFD ZalgirisVMFD Zalgiris |
| 20 Jul 21 | Qualifier        | Dinamo ZagrebDinamo Zagreb | 2 - 0 | Omonia NicosiaOmonia Nicosi |
| 20 Jul 21 | Qualifier        | Rapid ViennaRapid Vienna | 2 - 1 | Sparta PragueSparta Prague |
| 20 Jul 21 | Qualifier        | CelticCeltic | 1 - 1 | FC MidtjyllandFC Midtjyllan |
| 21 Jul 21 | Qualifier        | Kairat AlmatyKairat Almaty | 2 - 1 | Crvena ZvezdaCrvena Zvezda |
| 21 Jul 21 | Qualifier        | Malmo FFMalmo FF | 2 - 1 | HJK HelsinkiHJK Helsinki |
| 21 Jul 21 | Qualifier        | Slovan BratislavaSlovan Bratis | 0 - 0 | Young BoysYoung Boys |
| 21 Jul 21 | Qualifier        | NŠ MuraNŠ Mura | 0 - 0 | Ludogorets RazgradLudogorets Ra |
| 21 Jul 21 | Qualifier        | PSV EindhovenPSV Eindhoven | 5 - 1 | GalatasarayGalatasaray |
| 21 Jul 21 | Qualifier        | Legia WarsawLegia Warsaw | 2 - 1 | FC Flora TallinFC Flora Tall |
| 21 Jul 21 | Qualifier        | OlympiakosOlympiakos | 1 - 0 | Neftçi PFKNeftçi PFK |
| 27 Jul 21 | Qualifier        | HJK HelsinkiHJK Helsinki | 2 - 2 | Malmo FFMalmo FF |
| 27 Jul 21 | Qualifier        | FC Flora TallinFC Flora Tall | 0 - 1 | Legia WarsawLegia Warsaw |
| 27 Jul 21 | Qualifier        | Omonia NicosiaOmonia Nicosi | 0 - 1 | Dinamo ZagrebDinamo Zagreb |
| 27 Jul 21 | Qualifier        | VMFD ZalgirisVMFD Zalgiris | 1 - 3 | FerencvarosFerencvaros |
| 28 Jul 21 | Qualifier        | Neftçi PFKNeftçi PFK | 0 - 1 | OlympiakosOlympiakos |
| 28 Jul 21 | Qualifier        | Sheriff TiraspolSheriff Tiras | 3 - 1 | AlashkertAlashkert |
| 28 Jul 21 | Qualifier        | Young BoysYoung Boys | 3 - 2 | Slovan BratislavaSlovan Bratis |
| 28 Jul 21 | Qualifier        | Sparta PragueSparta Prague | 2 - 0 | Rapid ViennaRapid Vienna |
| 28 Jul 21 | Qualifier        | CFR Cluj-NapocaCFR Cluj-Napo | 2 - 0 | Lincoln Red ImpsLincoln Red I |
| 28 Jul 21 | Qualifier        | Crvena ZvezdaCrvena Zvezda | 5 - 0 | Kairat AlmatyKairat Almaty |
| 28 Jul 21 | Qualifier        | FC MidtjyllandFC Midtjyllan | 2 - 1 | CelticCeltic |
| 28 Jul 21 | Qualifier        | GalatasarayGalatasaray | 1 - 2 | PSV EindhovenPSV Eindhoven |
| 28 Jul 21 | Qualifier        | Ludogorets RazgradLudogorets Ra | 3 - 1 | NŠ MuraNŠ Mura |
| 03 Aug 21 | Qualifier        | Sparta PragueSparta Prague | 0 - 2 | MonacoMonaco |
| 03 Aug 21 | Qualifier        | Malmo FFMalmo FF | 2 - 1 | RangersRangers |
| 03 Aug 21 | Qualifier        | GenkGenk | 1 - 2 | Shakhtar DonetskShakhtar Done |
| 03 Aug 21 | Qualifier        | PSV EindhovenPSV Eindhoven | 3 - 0 | FC MidtjyllandFC Midtjyllan |
| 03 Aug 21 | Qualifier        | Crvena ZvezdaCrvena Zvezda | 1 - 1 | Sheriff TiraspolSheriff Tiras |
| 03 Aug 21 | Qualifier        | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 1 | Young BoysYoung Boys |
| 03 Aug 21 | Qualifier        | OlympiakosOlympiakos | 1 - 1 | Ludogorets RazgradLudogorets Ra |
| 04 Aug 21 | Qualifier        | Spartak MoscowSpartak Mosco | 0 - 2 | BenficaBenfica |
| 04 Aug 21 | Qualifier        | Dinamo ZagrebDinamo Zagreb | 1 - 1 | Legia WarsawLegia Warsaw |
| 04 Aug 21 | Qualifier        | FerencvarosFerencvaros | 2 - 0 | Slavia PragueSlavia Prague |
| 10 Aug 21 | Qualifier        | Slavia PragueSlavia Prague | 1 - 0 | FerencvarosFerencvaros |
| 10 Aug 21 | Qualifier        | Sheriff TiraspolSheriff Tiras | 1 - 0 | Crvena ZvezdaCrvena Zvezda |
| 10 Aug 21 | Qualifier        | Shakhtar DonetskShakhtar Done | 2 - 1 | GenkGenk |
| 10 Aug 21 | Qualifier        | Young BoysYoung Boys | 3 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 10 Aug 21 | Qualifier        | FC MidtjyllandFC Midtjyllan | 0 - 1 | PSV EindhovenPSV Eindhoven |
| 10 Aug 21 | Qualifier        | Ludogorets RazgradLudogorets Ra | 2 - 2 | OlympiakosOlympiakos |
| 10 Aug 21 | Qualifier        | MonacoMonaco | 3 - 1 | Sparta PragueSparta Prague |
| 10 Aug 21 | Qualifier        | BenficaBenfica | 2 - 0 | Spartak MoscowSpartak Mosco |
| 10 Aug 21 | Qualifier        | Legia WarsawLegia Warsaw | 0 - 1 | Dinamo ZagrebDinamo Zagreb |
| 10 Aug 21 | Qualifier        | RangersRangers | 1 - 2 | Malmo FFMalmo FF |
| 17 Aug 21 | Qualifier        | SV SalzburgSV Salzburg | 2 - 1 | BrøndbyBrøndby |
| 17 Aug 21 | Qualifier        | MonacoMonaco | 0 - 1 | Shakhtar DonetskShakhtar Done |
| 17 Aug 21 | Qualifier        | Sheriff TiraspolSheriff Tiras | 3 - 0 | Dinamo ZagrebDinamo Zagreb |
| 18 Aug 21 | Qualifier        | Young BoysYoung Boys | 3 - 2 | FerencvarosFerencvaros |
| 18 Aug 21 | Qualifier        | BenficaBenfica | 2 - 1 | PSV EindhovenPSV Eindhoven |
| 18 Aug 21 | Qualifier        | Malmo FFMalmo FF | 2 - 0 | Ludogorets RazgradLudogorets Ra |
| 24 Aug 21 | Qualifier        | Ludogorets RazgradLudogorets Ra | 2 - 1 | Malmo FFMalmo FF |
| 24 Aug 21 | Qualifier        | FerencvarosFerencvaros | 2 - 3 | Young BoysYoung Boys |
| 24 Aug 21 | Qualifier        | PSV EindhovenPSV Eindhoven | 0 - 0 | BenficaBenfica |
| 25 Aug 21 | Qualifier        | BrøndbyBrøndby | 1 - 2 | SV SalzburgSV Salzburg |
| 25 Aug 21 | Qualifier        | Dinamo ZagrebDinamo Zagreb | 0 - 0 | Sheriff TiraspolSheriff Tiras |
| 25 Aug 21 | Qualifier        | Shakhtar DonetskShakhtar Done | 2 - 2 | MonacoMonaco |
| |
| 14 Sep 21 | r01        | Young BoysYoung Boys | 2 - 1 | Manchester UnitedManchester Un |
| 14 Sep 21 | r01        | SevillaSevilla | 1 - 1 | SV SalzburgSV Salzburg |
| 14 Sep 21 | r01        | BarcelonaBarcelona | 0 - 3 | Bayern MunichBayern Munich |
| 14 Sep 21 | r01        | Dynamo KievDynamo Kiev | 0 - 0 | BenficaBenfica |
| 14 Sep 21 | r01        | VillarrealVillarreal | 2 - 2 | AtalantaAtalanta |
| 14 Sep 21 | r01        | LilleLille | 0 - 0 | WolfsburgWolfsburg |
| 14 Sep 21 | r01        | ChelseaChelsea | 1 - 0 | Zenit St PetersburgZenit St Pete |
| 14 Sep 21 | r01        | Malmo FFMalmo FF | 0 - 3 | JuventusJuventus |
| 15 Sep 21 | r01        | BesiktasBesiktas | 1 - 2 | DortmundDortmund |
| 15 Sep 21 | r01        | Sheriff TiraspolSheriff Tiras | 2 - 0 | Shakhtar DonetskShakhtar Done |
| 15 Sep 21 | r01        | Manchester CityManchester Ci | 6 - 3 | RasenBallsport LeipzigRasenBallspor |
| 15 Sep 21 | r01        | Club BruggeClub Brugge | 1 - 1 | Paris SGParis SG |
| 15 Sep 21 | r01        | Ath MadridAth Madrid | 0 - 0 | FC PortoFC Porto |
| 15 Sep 21 | r01        | LiverpoolLiverpool | 3 - 2 | MilanMilan |
| 15 Sep 21 | r01        | Sporting CPSporting CP | 1 - 5 | AjaxAjax |
| 15 Sep 21 | r01        | InterInter | 0 - 1 | Real MadridReal Madrid |
| |
| 28 Sep 21 | r02        | AjaxAjax | 2 - 0 | BesiktasBesiktas |
| 28 Sep 21 | r02        | Shakhtar DonetskShakhtar Done | 0 - 0 | InterInter |
| 28 Sep 21 | r02        | RasenBallsport LeipzigRasenBallspor | 1 - 2 | Club BruggeClub Brugge |
| 28 Sep 21 | r02        | DortmundDortmund | 1 - 0 | Sporting CPSporting CP |
| 28 Sep 21 | r02        | Paris SGParis SG | 2 - 0 | Manchester CityManchester Ci |
| 28 Sep 21 | r02        | FC PortoFC Porto | 1 - 5 | LiverpoolLiverpool |
| 28 Sep 21 | r02        | MilanMilan | 1 - 2 | Ath MadridAth Madrid |
| 28 Sep 21 | r02        | Real MadridReal Madrid | 1 - 2 | Sheriff TiraspolSheriff Tiras |
| 29 Sep 21 | r02        | AtalantaAtalanta | 1 - 0 | Young BoysYoung Boys |
| 29 Sep 21 | r02        | Zenit St PetersburgZenit St Pete | 4 - 0 | Malmo FFMalmo FF |
| 29 Sep 21 | r02        | SV SalzburgSV Salzburg | 2 - 1 | LilleLille |
| 29 Sep 21 | r02        | Bayern MunichBayern Munich | 5 - 0 | Dynamo KievDynamo Kiev |
| 29 Sep 21 | r02        | BenficaBenfica | 3 - 0 | BarcelonaBarcelona |
| 29 Sep 21 | r02        | Manchester UnitedManchester Un | 2 - 1 | VillarrealVillarreal |
| 29 Sep 21 | r02        | WolfsburgWolfsburg | 1 - 1 | SevillaSevilla |
| 29 Sep 21 | r02        | JuventusJuventus | 1 - 0 | ChelseaChelsea |
| |
| 19 Oct 21 | r03        | BesiktasBesiktas | 1 - 4 | Sporting CPSporting CP |
| 19 Oct 21 | r03        | Club BruggeClub Brugge | 1 - 5 | Manchester CityManchester Ci |
| 19 Oct 21 | r03        | Paris SGParis SG | 3 - 2 | RasenBallsport LeipzigRasenBallspor |
| 19 Oct 21 | r03        | Ath MadridAth Madrid | 2 - 3 | LiverpoolLiverpool |
| 19 Oct 21 | r03        | FC PortoFC Porto | 1 - 0 | MilanMilan |
| 19 Oct 21 | r03        | AjaxAjax | 4 - 0 | DortmundDortmund |
| 19 Oct 21 | r03        | Shakhtar DonetskShakhtar Done | 0 - 5 | Real MadridReal Madrid |
| 19 Oct 21 | r03        | InterInter | 3 - 1 | Sheriff TiraspolSheriff Tiras |
| 20 Oct 21 | r03        | BarcelonaBarcelona | 1 - 0 | Dynamo KievDynamo Kiev |
| 20 Oct 21 | r03        | SV SalzburgSV Salzburg | 3 - 1 | WolfsburgWolfsburg |
| 20 Oct 21 | r03        | Young BoysYoung Boys | 1 - 4 | VillarrealVillarreal |
| 20 Oct 21 | r03        | BenficaBenfica | 0 - 4 | Bayern MunichBayern Munich |
| 20 Oct 21 | r03        | Manchester UnitedManchester Un | 3 - 2 | AtalantaAtalanta |
| 20 Oct 21 | r03        | LilleLille | 0 - 0 | SevillaSevilla |
| 20 Oct 21 | r03        | ChelseaChelsea | 4 - 0 | Malmo FFMalmo FF |
| 20 Oct 21 | r03        | Zenit St PetersburgZenit St Pete | 0 - 1 | JuventusJuventus |
| |
| 02 Nov 21 | r04        | WolfsburgWolfsburg | 2 - 1 | SV SalzburgSV Salzburg |
| 02 Nov 21 | r04        | Malmo FFMalmo FF | 0 - 1 | ChelseaChelsea |
| 02 Nov 21 | r04        | Bayern MunichBayern Munich | 5 - 2 | BenficaBenfica |
| 02 Nov 21 | r04        | Dynamo KievDynamo Kiev | 0 - 1 | BarcelonaBarcelona |
| 02 Nov 21 | r04        | AtalantaAtalanta | 2 - 2 | Manchester UnitedManchester Un |
| 02 Nov 21 | r04        | VillarrealVillarreal | 2 - 0 | Young BoysYoung Boys |
| 02 Nov 21 | r04        | SevillaSevilla | 1 - 2 | LilleLille |
| 02 Nov 21 | r04        | JuventusJuventus | 4 - 2 | Zenit St PetersburgZenit St Pete |
| 03 Nov 21 | r04        | MilanMilan | 1 - 1 | FC PortoFC Porto |
| 03 Nov 21 | r04        | Real MadridReal Madrid | 2 - 1 | Shakhtar DonetskShakhtar Done |
| 03 Nov 21 | r04        | Manchester CityManchester Ci | 4 - 1 | Club BruggeClub Brugge |
| 03 Nov 21 | r04        | RasenBallsport LeipzigRasenBallspor | 2 - 2 | Paris SGParis SG |
| 03 Nov 21 | r04        | LiverpoolLiverpool | 2 - 0 | Ath MadridAth Madrid |
| 03 Nov 21 | r04        | DortmundDortmund | 1 - 3 | AjaxAjax |
| 03 Nov 21 | r04        | Sporting CPSporting CP | 4 - 0 | BesiktasBesiktas |
| 03 Nov 21 | r04        | Sheriff TiraspolSheriff Tiras | 1 - 3 | InterInter |
| |
| 23 Nov 21 | r05        | Dynamo KievDynamo Kiev | 1 - 2 | Bayern MunichBayern Munich |
| 23 Nov 21 | r05        | VillarrealVillarreal | 0 - 2 | Manchester UnitedManchester Un |
| 23 Nov 21 | r05        | BarcelonaBarcelona | 0 - 0 | BenficaBenfica |
| 23 Nov 21 | r05        | Young BoysYoung Boys | 3 - 3 | AtalantaAtalanta |
| 23 Nov 21 | r05        | SevillaSevilla | 2 - 0 | WolfsburgWolfsburg |
| 23 Nov 21 | r05        | LilleLille | 1 - 0 | SV SalzburgSV Salzburg |
| 23 Nov 21 | r05        | ChelseaChelsea | 4 - 0 | JuventusJuventus |
| 23 Nov 21 | r05        | Malmo FFMalmo FF | 1 - 1 | Zenit St PetersburgZenit St Pete |
| 24 Nov 21 | r05        | BesiktasBesiktas | 1 - 2 | AjaxAjax |
| 24 Nov 21 | r05        | InterInter | 2 - 0 | Shakhtar DonetskShakhtar Done |
| 24 Nov 21 | r05        | Manchester CityManchester Ci | 2 - 1 | Paris SGParis SG |
| 24 Nov 21 | r05        | Club BruggeClub Brugge | 0 - 5 | RasenBallsport LeipzigRasenBallspor |
| 24 Nov 21 | r05        | Ath MadridAth Madrid | 0 - 1 | MilanMilan |
| 24 Nov 21 | r05        | LiverpoolLiverpool | 2 - 0 | FC PortoFC Porto |
| 24 Nov 21 | r05        | Sporting CPSporting CP | 3 - 1 | DortmundDortmund |
| 24 Nov 21 | r05        | Sheriff TiraspolSheriff Tiras | 0 - 3 | Real MadridReal Madrid |
| |
| 07 Dec 21 | r06        | Paris SGParis SG | 4 - 1 | Club BruggeClub Brugge |
| 07 Dec 21 | r06        | RasenBallsport LeipzigRasenBallspor | 2 - 1 | Manchester CityManchester Ci |
| 07 Dec 21 | r06        | MilanMilan | 1 - 2 | LiverpoolLiverpool |
| 07 Dec 21 | r06        | FC PortoFC Porto | 1 - 3 | Ath MadridAth Madrid |
| 07 Dec 21 | r06        | DortmundDortmund | 5 - 0 | BesiktasBesiktas |
| 07 Dec 21 | r06        | AjaxAjax | 4 - 2 | Sporting CPSporting CP |
| 07 Dec 21 | r06        | Real MadridReal Madrid | 2 - 0 | InterInter |
| 07 Dec 21 | r06        | Shakhtar DonetskShakhtar Done | 1 - 1 | Sheriff TiraspolSheriff Tiras |
| 08 Dec 21 | r06        | JuventusJuventus | 1 - 0 | Malmo FFMalmo FF |
| 08 Dec 21 | r06        | Zenit St PetersburgZenit St Pete | 3 - 3 | ChelseaChelsea |
| 08 Dec 21 | r06        | Bayern MunichBayern Munich | 3 - 0 | BarcelonaBarcelona |
| 08 Dec 21 | r06        | BenficaBenfica | 2 - 0 | Dynamo KievDynamo Kiev |
| 08 Dec 21 | r06        | Manchester UnitedManchester Un | 1 - 1 | Young BoysYoung Boys |
| 08 Dec 21 | r06        | SV SalzburgSV Salzburg | 1 - 0 | SevillaSevilla |
| 08 Dec 21 | r06        | WolfsburgWolfsburg | 1 - 3 | LilleLille |
| 09 Dec 21 | r06        | AtalantaAtalanta | 2 - 3 | VillarrealVillarreal |
| |
| 15 Feb 22 | r16        | Sporting CPSporting CP | 0 - 5 | Manchester CityManchester Ci |
| 15 Feb 22 | r16        | Paris SGParis SG | 1 - 0 | Real MadridReal Madrid |
| 16 Feb 22 | r16        | SV SalzburgSV Salzburg | 1 - 1 | Bayern MunichBayern Munich |
| 16 Feb 22 | r16        | InterInter | 0 - 2 | LiverpoolLiverpool |
| 22 Feb 22 | r16        | ChelseaChelsea | 2 - 0 | LilleLille |
| 22 Feb 22 | r16        | VillarrealVillarreal | 1 - 1 | JuventusJuventus |
| 23 Feb 22 | r16        | BenficaBenfica | 2 - 2 | AjaxAjax |
| 23 Feb 22 | r16        | Ath MadridAth Madrid | 1 - 1 | Manchester UnitedManchester Un |
| 08 Mar 22 | r16        | Bayern MunichBayern Munich | 7 - 1 | SV SalzburgSV Salzburg |
| 08 Mar 22 | r16        | LiverpoolLiverpool | 0 - 1 | InterInter |
| 09 Mar 22 | r16        | Manchester CityManchester Ci | 0 - 0 | Sporting CPSporting CP |
| 09 Mar 22 | r16        | Real MadridReal Madrid | 3 - 1 | Paris SGParis SG |
| 15 Mar 22 | r16        | AjaxAjax | 0 - 1 | BenficaBenfica |
| 15 Mar 22 | r16        | Manchester UnitedManchester Un | 0 - 1 | Ath MadridAth Madrid |
| 16 Mar 22 | r16        | LilleLille | 1 - 2 | ChelseaChelsea |
| 16 Mar 22 | r16        | JuventusJuventus | 0 - 3 | VillarrealVillarreal |
| |
| 05 Apr 22 | QF        | Manchester CityManchester Ci | 1 - 0 | Ath MadridAth Madrid |
| 05 Apr 22 | QF        | BenficaBenfica | 1 - 3 | LiverpoolLiverpool |
| 06 Apr 22 | QF        | ChelseaChelsea | 1 - 3 | Real MadridReal Madrid |
| 06 Apr 22 | QF        | VillarrealVillarreal | 1 - 0 | Bayern MunichBayern Munich |
| 12 Apr 22 | QF        | Real MadridReal Madrid | 2 - 3 | ChelseaChelsea |
| 12 Apr 22 | QF        | Bayern MunichBayern Munich | 1 - 1 | VillarrealVillarreal |
| 13 Apr 22 | QF        | Ath MadridAth Madrid | 0 - 0 | Manchester CityManchester Ci |
| 13 Apr 22 | QF        | LiverpoolLiverpool | 3 - 3 | BenficaBenfica |
| |
| 26 Apr 22 | SF        | Manchester CityManchester Ci | 4 - 3 | Real MadridReal Madrid |
| 27 Apr 22 | SF        | LiverpoolLiverpool | 2 - 0 | VillarrealVillarreal |
| 03 May 22 | SF        | VillarrealVillarreal | 2 - 3 | LiverpoolLiverpool |
| 04 May 22 | SF        | Real MadridReal Madrid | 3 - 1 | Manchester CityManchester Ci |
| |
| 28 May 22 | Final        | LiverpoolLiverpool | 0 - 1 | Real MadridReal Madrid |