| 22 Oct 21 | r10        | Flint Town UnitedFlint Town Un | 1 - 1 | TNSTNS |
| 22 Oct 21 | r10        | Aberystwyth TownAberystwyth T | 0 - 3 | Pen-y-BontPen-y-Bont |
| 23 Oct 21 | r10        | BalaBala | 3 - 3 | Barry Town UnitedBarry Town Un |
| 23 Oct 21 | r10        | Cardiff Metropolitan UnivCardiff Metro | 1 - 1 | Connah's Quay NomadsConnah's Quay |
| 23 Oct 21 | r10        | Haverfordwest CountyHaverfordwest | 2 - 1 | Newi Cefn DruidsNewi Cefn Dru |
| 23 Oct 21 | r10        | NewtownNewtown | 1 - 0 | Caernarfon Town FCCaernarfon To |
| 23 Apr 22 | r10        | BalaBala | 11 - 0 | Pen-y-BontPen-y-Bont |
| 23 Apr 22 | r10        | Flint Town UnitedFlint Town Un | 1 - 1 | NewtownNewtown |
| 23 Apr 22 | r10        | TNSTNS | 3 - 1 | Connah's Quay NomadsConnah's Quay |
| 23 Apr 22 | r10        | Aberystwyth TownAberystwyth T | 1 - 1 | Caernarfon Town FCCaernarfon To |
| 23 Apr 22 | r10        | Newi Cefn DruidsNewi Cefn Dru | 1 - 0 | Barry Town UnitedBarry Town Un |
| 23 Apr 22 | r10        | Haverfordwest CountyHaverfordwest | 1 - 2 | Cardiff Metropolitan UnivCardiff Metro |