| 12 Oct 21 | r09        | Barry Town UnitedBarry Town Un | 0 - 1 | Cardiff Metropolitan UnivCardiff Metro |
| 12 Oct 21 | r09        | Caernarfon Town FCCaernarfon To | 2 - 3 | Flint Town UnitedFlint Town Un |
| 12 Oct 21 | r09        | Connah's Quay NomadsConnah's Quay | 0 - 2 | NewtownNewtown |
| 12 Oct 21 | r09        | Pen-y-BontPen-y-Bont | 2 - 1 | Haverfordwest CountyHaverfordwest |
| 12 Oct 21 | r09        | TNSTNS | 2 - 1 | BalaBala |
| 13 Oct 21 | r09        | Newi Cefn DruidsNewi Cefn Dru | 0 - 1 | Aberystwyth TownAberystwyth T |
| 18 Apr 22 | r09        | Connah's Quay NomadsConnah's Quay | 0 - 2 | BalaBala |
| 18 Apr 22 | r09        | NewtownNewtown | 0 - 2 | TNSTNS |
| 18 Apr 22 | r09        | Pen-y-BontPen-y-Bont | 0 - 3 | Flint Town UnitedFlint Town Un |
| 18 Apr 22 | r09        | Caernarfon Town FCCaernarfon To | 3 - 0 | Haverfordwest CountyHaverfordwest |
| 18 Apr 22 | r09        | Cardiff Metropolitan UnivCardiff Metro | 5 - 0 | Newi Cefn DruidsNewi Cefn Dru |
| 18 Apr 22 | r09        | Barry Town UnitedBarry Town Un | 0 - 1 | Aberystwyth TownAberystwyth T |