


| 17 Sep 22 | r01 | ScarletsScarlets | 23 - 23 | OspreysOspreys |
| 24 Sep 22 | r02 | OspreysOspreys | 27 - 28 | Lions Super RugbyLions Super R |
| 01 Oct 22 | r03 | OspreysOspreys | 32 - 17 | GlasgowGlasgow |
| 08 Oct 22 | r04 | UlsterUlster | 47 - 17 | OspreysOspreys |
| 14 Oct 22 | r05 | OspreysOspreys | 16 - 16 | StormersStormers |
| 23 Oct 22 | r06 | DragonsDragons | 32 - 25 | OspreysOspreys |
| 29 Oct 22 | r07 | OspreysOspreys | 19 - 22 | ConnachtConnacht |
| 26 Nov 22 | r08 | Bulls Super RugbyBulls Super R | 43 - 26 | OspreysOspreys |
| 02 Dec 22 | r09 | The SharksThe Sharks | 25 - 10 | OspreysOspreys |
| 26 Dec 22 | r10 | OspreysOspreys | 34 - 14 | ScarletsScarlets |
| 01 Jan 23 | r11 | Cardiff RugbyCardiff Rugby | 19 - 22 | OspreysOspreys |
| 07 Jan 23 | r12 | OspreysOspreys | 19 - 24 | LeinsterLeinster |
| 29 Jan 23 | r13 | ZebreZebre | 24 - 28 | OspreysOspreys |
| 17 Feb 23 | r14 | MunsterMunster | 58 - 3 | OspreysOspreys |
| 04 Mar 23 | r15 | OspreysOspreys | 20 - 21 | BenettonBenetton |
| 25 Mar 23 | r16 | OspreysOspreys | 37 - 18 | DragonsDragons |
| 15 Apr 23 | r17 | EdinburghEdinburgh | 45 - 21 | OspreysOspreys |
| 22 Apr 23 | r18 | OspreysOspreys | 21 - 38 | Cardiff RugbyCardiff Rugby |