| 17 Sep 22 | r01        | Cardiff RugbyCardiff Rugby | 20 - 13 | MunsterMunster |
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| 23 Sep 22 | r02        | GlasgowGlasgow | 52 - 24 | Cardiff RugbyCardiff Rugby |
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| 30 Sep 22 | r03        | Cardiff RugbyCardiff Rugby | 18 - 31 | Lions Super RugbyLions Super R |
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| 08 Oct 22 | r04        | ScarletsScarlets | 10 - 16 | Cardiff RugbyCardiff Rugby |
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| 15 Oct 22 | r05        | Cardiff RugbyCardiff Rugby | 31 - 14 | DragonsDragons |
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| 22 Oct 22 | r06        | Cardiff RugbyCardiff Rugby | 30 - 24 | StormersStormers |
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| 30 Oct 22 | r07        | Cardiff RugbyCardiff Rugby | 17 - 25 | EdinburghEdinburgh |
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| 27 Nov 22 | r08        | The SharksThe Sharks | 0 - 35 | Cardiff RugbyCardiff Rugby |
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| 03 Dec 22 | r09        | Bulls Super RugbyBulls Super R | 45 - 9 | Cardiff RugbyCardiff Rugby |
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| 26 Dec 22 | r10        | DragonsDragons | 24 - 29 | Cardiff RugbyCardiff Rugby |
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| 01 Jan 23 | r11        | Cardiff RugbyCardiff Rugby | 19 - 22 | OspreysOspreys |
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| 07 Jan 23 | r12        | Cardiff RugbyCardiff Rugby | 22 - 28 | ScarletsScarlets |
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| 28 Jan 23 | r13        | LeinsterLeinster | 38 - 14 | Cardiff RugbyCardiff Rugby |
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| 18 Feb 23 | r14        | Cardiff RugbyCardiff Rugby | 30 - 13 | BenettonBenetton |
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| 04 Mar 23 | r15        | Cardiff RugbyCardiff Rugby | 20 - 42 | UlsterUlster |
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| 24 Mar 23 | r16        | ZebreZebre | 30 - 34 | Cardiff RugbyCardiff Rugby |
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| 15 Apr 23 | r17        | ConnachtConnacht | 38 - 19 | Cardiff RugbyCardiff Rugby |
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| 22 Apr 23 | r18        | OspreysOspreys | 21 - 38 | Cardiff RugbyCardiff Rugby |