

| 07 Oct 22 | r04 | ConnachtConnacht | 20 - 11 | MunsterMunster |
| 07 Oct 22 | r04 | EdinburghEdinburgh | 19 - 22 | Lions Super RugbyLions Super R |
| 08 Oct 22 | r04 | ZebreZebre | 20 - 37 | StormersStormers |
| 08 Oct 22 | r04 | LeinsterLeinster | 54 - 34 | The SharksThe Sharks |
| 08 Oct 22 | r04 | ScarletsScarlets | 10 - 16 | Cardiff RugbyCardiff Rugby |
| 08 Oct 22 | r04 | GlasgowGlasgow | 35 - 21 | Bulls Super RugbyBulls Super R |
| 08 Oct 22 | r04 | UlsterUlster | 47 - 17 | OspreysOspreys |
| 09 Oct 22 | r04 | BenettonBenetton | 34 - 14 | DragonsDragons |