| 24 Sep 21 | r01        | ZebreZebre | 26 - 38 | Lions Super RugbyLions Super R |
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| 01 Oct 21 | r02        | ScarletsScarlets | 36 - 13 | Lions Super RugbyLions Super R |
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| 09 Oct 21 | r03        | GlasgowGlasgow | 13 - 9 | Lions Super RugbyLions Super R |
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| 15 Oct 21 | r04        | UlsterUlster | 26 - 10 | Lions Super RugbyLions Super R |
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| 04 Dec 21 | r08        | StormersStormers | 19 - 37 | Lions Super RugbyLions Super R |
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| 22 Jan 22 | r05        | Lions Super RugbyLions Super R | 37 - 47 | The SharksThe Sharks |
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| 29 Jan 22 | r11        | Lions Super RugbyLions Super R | 10 - 34 | Bulls Super RugbyBulls Super R |
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| 05 Feb 22 | r09        | Bulls Super RugbyBulls Super R | 21 - 13 | Lions Super RugbyLions Super R |
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| 12 Feb 22 | r12        | Lions Super RugbyLions Super R | 10 - 32 | StormersStormers |
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| 25 Feb 22 | r10        | LeinsterLeinster | 21 - 13 | Lions Super RugbyLions Super R |
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| 13 Mar 22 | r06        | Lions Super RugbyLions Super R | 37 - 20 | Cardiff RugbyCardiff Rugby |
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| 19 Mar 22 | r07        | Lions Super RugbyLions Super R | 23 - 21 | MunsterMunster |
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| 25 Mar 22 | r14        | Lions Super RugbyLions Super R | 45 - 15 | OspreysOspreys |
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| 02 Apr 22 | r15        | Lions Super RugbyLions Super R | 15 - 9 | EdinburghEdinburgh |
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| 09 Apr 22 | r13        | The SharksThe Sharks | 37 - 10 | Lions Super RugbyLions Super R |
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| 23 Apr 22 | r16        | Lions Super RugbyLions Super R | 30 - 33 | ConnachtConnacht |
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| 30 Apr 22 | r17        | Lions Super RugbyLions Super R | 37 - 29 | BenettonBenetton |
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| 21 May 22 | r18        | DragonsDragons | 11 - 21 | Lions Super RugbyLions Super R |