


| 24 Sep 21 | r01 | ZebreZebre | 26 - 38 | Lions Super RugbyLions Super R |
| 02 Oct 21 | r02 | ZebreZebre | 3 - 36 | UlsterUlster |
| 09 Oct 21 | r03 | LeinsterLeinster | 43 - 7 | ZebreZebre |
| 16 Oct 21 | r04 | ZebreZebre | 6 - 17 | GlasgowGlasgow |
| 23 Oct 21 | r05 | ZebreZebre | 10 - 27 | EdinburghEdinburgh |
| 24 Dec 21 | r08 | ZebreZebre | 14 - 39 | BenettonBenetton |
| 29 Jan 22 | r11 | ZebreZebre | 17 - 34 | MunsterMunster |
| 25 Feb 22 | r10 | ZebreZebre | 7 - 45 | Bulls Super RugbyBulls Super R |
| 06 Mar 22 | r13 | OspreysOspreys | 27 - 22 | ZebreZebre |
| 13 Mar 22 | r06 | StormersStormers | 55 - 7 | ZebreZebre |
| 19 Mar 22 | r07 | The SharksThe Sharks | 38 - 6 | ZebreZebre |
| 26 Mar 22 | r14 | ZebreZebre | 24 - 41 | ScarletsScarlets |
| 01 Apr 22 | r15 | GlasgowGlasgow | 40 - 12 | ZebreZebre |
| 22 Apr 22 | r16 | EdinburghEdinburgh | 29 - 26 | ZebreZebre |
| 30 Apr 22 | r17 | ZebreZebre | 23 - 18 | DragonsDragons |
| 06 May 22 | r12 | Cardiff RugbyCardiff Rugby | 42 - 14 | ZebreZebre |
| 14 May 22 | r09 | BenettonBenetton | 39 - 17 | ZebreZebre |
| 21 May 22 | r18 | ConnachtConnacht | 22 - 20 | ZebreZebre |