


| 26 Sep 21 | r01 | DragonsDragons | 23 - 27 | OspreysOspreys |
| 02 Oct 21 | r02 | OspreysOspreys | 18 - 14 | Cardiff RugbyCardiff Rugby |
| 08 Oct 21 | r03 | OspreysOspreys | 13 - 27 | The SharksThe Sharks |
| 16 Oct 21 | r04 | BenettonBenetton | 26 - 29 | OspreysOspreys |
| 23 Oct 21 | r05 | OspreysOspreys | 18 - 10 | MunsterMunster |
| 26 Nov 21 | r06 | ConnachtConnacht | 46 - 18 | OspreysOspreys |
| 04 Dec 21 | r07 | OspreysOspreys | 19 - 13 | UlsterUlster |
| 01 Jan 22 | r09 | ScarletsScarlets | 22 - 19 | OspreysOspreys |
| 08 Jan 22 | r10 | GlasgowGlasgow | 38 - 19 | OspreysOspreys |
| 29 Jan 22 | r11 | OspreysOspreys | 23 - 19 | EdinburghEdinburgh |
| 19 Feb 22 | r12 | LeinsterLeinster | 29 - 7 | OspreysOspreys |
| 06 Mar 22 | r13 | OspreysOspreys | 27 - 22 | ZebreZebre |
| 25 Mar 22 | r14 | Lions Super RugbyLions Super R | 45 - 15 | OspreysOspreys |
| 02 Apr 22 | r15 | StormersStormers | 29 - 13 | OspreysOspreys |
| 23 Apr 22 | r16 | Cardiff RugbyCardiff Rugby | 6 - 22 | OspreysOspreys |
| 30 Apr 22 | r17 | OspreysOspreys | 54 - 36 | ScarletsScarlets |
| 08 May 22 | r08 | OspreysOspreys | 50 - 31 | DragonsDragons |
| 20 May 22 | r18 | OspreysOspreys | 31 - 38 | Bulls Super RugbyBulls Super R |