


| 26 Sep 21 | r01 | DragonsDragons | 23 - 27 | OspreysOspreys |
| 03 Oct 21 | r02 | DragonsDragons | 6 - 7 | LeinsterLeinster |
| 09 Oct 21 | r03 | ConnachtConnacht | 22 - 35 | DragonsDragons |
| 15 Oct 21 | r04 | DragonsDragons | 10 - 24 | StormersStormers |
| 23 Oct 21 | r05 | Cardiff RugbyCardiff Rugby | 31 - 29 | DragonsDragons |
| 27 Nov 21 | r06 | DragonsDragons | 14 - 30 | EdinburghEdinburgh |
| 04 Dec 21 | r07 | GlasgowGlasgow | 33 - 14 | DragonsDragons |
| 28 Jan 22 | r11 | DragonsDragons | 13 - 13 | BenettonBenetton |
| 20 Feb 22 | r12 | DragonsDragons | 0 - 12 | UlsterUlster |
| 05 Mar 22 | r13 | MunsterMunster | 64 - 3 | DragonsDragons |
| 26 Mar 22 | r14 | Bulls Super RugbyBulls Super R | 55 - 20 | DragonsDragons |
| 01 Apr 22 | r15 | The SharksThe Sharks | 51 - 3 | DragonsDragons |
| 16 Apr 22 | r10 | ScarletsScarlets | 27 - 38 | DragonsDragons |
| 23 Apr 22 | r16 | DragonsDragons | 19 - 38 | ScarletsScarlets |
| 30 Apr 22 | r17 | ZebreZebre | 23 - 18 | DragonsDragons |
| 08 May 22 | r08 | OspreysOspreys | 50 - 31 | DragonsDragons |
| 13 May 22 | r09 | DragonsDragons | 18 - 19 | Cardiff RugbyCardiff Rugby |
| 21 May 22 | r18 | DragonsDragons | 11 - 21 | Lions Super RugbyLions Super R |