


| 24 Sep 21 | r01 | Cardiff RugbyCardiff Rugby | 33 - 21 | ConnachtConnacht |
| 01 Oct 21 | r02 | ConnachtConnacht | 34 - 7 | Bulls Super RugbyBulls Super R |
| 09 Oct 21 | r03 | ConnachtConnacht | 22 - 35 | DragonsDragons |
| 16 Oct 21 | r04 | MunsterMunster | 20 - 18 | ConnachtConnacht |
| 23 Oct 21 | r05 | ConnachtConnacht | 36 - 11 | UlsterUlster |
| 26 Nov 21 | r06 | ConnachtConnacht | 46 - 18 | OspreysOspreys |
| 03 Dec 21 | r07 | LeinsterLeinster | 47 - 19 | ConnachtConnacht |
| 01 Jan 22 | r09 | ConnachtConnacht | 10 - 8 | MunsterMunster |
| 29 Jan 22 | r11 | ConnachtConnacht | 20 - 42 | GlasgowGlasgow |
| 04 Feb 22 | r08 | UlsterUlster | 32 - 12 | ConnachtConnacht |
| 19 Feb 22 | r12 | ScarletsScarlets | 23 - 29 | ConnachtConnacht |
| 26 Feb 22 | r10 | ConnachtConnacht | 19 - 17 | StormersStormers |
| 04 Mar 22 | r13 | EdinburghEdinburgh | 56 - 8 | ConnachtConnacht |
| 26 Mar 22 | r14 | ConnachtConnacht | 8 - 45 | LeinsterLeinster |
| 02 Apr 22 | r15 | BenettonBenetton | 17 - 21 | ConnachtConnacht |
| 23 Apr 22 | r16 | Lions Super RugbyLions Super R | 30 - 33 | ConnachtConnacht |
| 30 Apr 22 | r17 | The SharksThe Sharks | 41 - 21 | ConnachtConnacht |
| 21 May 22 | r18 | ConnachtConnacht | 22 - 20 | ZebreZebre |