| 24 Sep 21 | r01        | Cardiff RugbyCardiff Rugby | 33 - 21 | ConnachtConnacht |
| |
| 02 Oct 21 | r02        | OspreysOspreys | 18 - 14 | Cardiff RugbyCardiff Rugby |
| |
| 09 Oct 21 | r03        | Cardiff RugbyCardiff Rugby | 19 - 29 | Bulls Super RugbyBulls Super R |
| |
| 16 Oct 21 | r04        | Cardiff RugbyCardiff Rugby | 23 - 17 | The SharksThe Sharks |
| |
| 23 Oct 21 | r05        | Cardiff RugbyCardiff Rugby | 31 - 29 | DragonsDragons |
| |
| 08 Jan 22 | r10        | EdinburghEdinburgh | 34 - 10 | Cardiff RugbyCardiff Rugby |
| |
| 29 Jan 22 | r11        | Cardiff RugbyCardiff Rugby | 29 - 27 | LeinsterLeinster |
| |
| 04 Mar 22 | r13        | UlsterUlster | 48 - 12 | Cardiff RugbyCardiff Rugby |
| |
| 13 Mar 22 | r06        | Lions Super RugbyLions Super R | 37 - 20 | Cardiff RugbyCardiff Rugby |
| |
| 20 Mar 22 | r07        | StormersStormers | 40 - 3 | Cardiff RugbyCardiff Rugby |
| |
| 26 Mar 22 | r14        | Cardiff RugbyCardiff Rugby | 32 - 28 | GlasgowGlasgow |
| |
| 02 Apr 22 | r15        | ScarletsScarlets | 35 - 20 | Cardiff RugbyCardiff Rugby |
| |
| 09 Apr 22 | r08        | Cardiff RugbyCardiff Rugby | 14 - 49 | ScarletsScarlets |
| |
| 23 Apr 22 | r16        | Cardiff RugbyCardiff Rugby | 6 - 22 | OspreysOspreys |
| |
| 29 Apr 22 | r17        | MunsterMunster | 42 - 21 | Cardiff RugbyCardiff Rugby |
| |
| 06 May 22 | r12        | Cardiff RugbyCardiff Rugby | 42 - 14 | ZebreZebre |
| |
| 13 May 22 | r09        | DragonsDragons | 18 - 19 | Cardiff RugbyCardiff Rugby |
| |
| 20 May 22 | r18        | BenettonBenetton | 69 - 21 | Cardiff RugbyCardiff Rugby |