| 24 Sep 21 | r01        | ZebreZebre | 26 - 38 | Lions Super RugbyLions Super R |
| 24 Sep 21 | r01        | UlsterUlster | 35 - 29 | GlasgowGlasgow |
| 24 Sep 21 | r01        | Cardiff RugbyCardiff Rugby | 33 - 21 | ConnachtConnacht |
| 25 Sep 21 | r01        | BenettonBenetton | 22 - 18 | StormersStormers |
| 25 Sep 21 | r01        | LeinsterLeinster | 31 - 3 | Bulls Super RugbyBulls Super R |
| 25 Sep 21 | r01        | EdinburghEdinburgh | 26 - 22 | ScarletsScarlets |
| 25 Sep 21 | r01        | MunsterMunster | 42 - 17 | The SharksThe Sharks |
| 26 Sep 21 | r01        | DragonsDragons | 23 - 27 | OspreysOspreys |
| |
| 01 Oct 21 | r02        | ScarletsScarlets | 36 - 13 | Lions Super RugbyLions Super R |
| 01 Oct 21 | r02        | ConnachtConnacht | 34 - 7 | Bulls Super RugbyBulls Super R |
| 02 Oct 21 | r02        | BenettonBenetton | 28 - 27 | EdinburghEdinburgh |
| 02 Oct 21 | r02        | GlasgowGlasgow | 35 - 24 | The SharksThe Sharks |
| 02 Oct 21 | r02        | ZebreZebre | 3 - 36 | UlsterUlster |
| 02 Oct 21 | r02        | OspreysOspreys | 18 - 14 | Cardiff RugbyCardiff Rugby |
| 02 Oct 21 | r02        | MunsterMunster | 34 - 18 | StormersStormers |
| 03 Oct 21 | r02        | DragonsDragons | 6 - 7 | LeinsterLeinster |
| |
| 08 Oct 21 | r03        | OspreysOspreys | 13 - 27 | The SharksThe Sharks |
| 08 Oct 21 | r03        | UlsterUlster | 28 - 8 | BenettonBenetton |
| 09 Oct 21 | r03        | LeinsterLeinster | 43 - 7 | ZebreZebre |
| 09 Oct 21 | r03        | GlasgowGlasgow | 13 - 9 | Lions Super RugbyLions Super R |
| 09 Oct 21 | r03        | ConnachtConnacht | 22 - 35 | DragonsDragons |
| 09 Oct 21 | r03        | EdinburghEdinburgh | 20 - 20 | StormersStormers |
| 09 Oct 21 | r03        | Cardiff RugbyCardiff Rugby | 19 - 29 | Bulls Super RugbyBulls Super R |
| 10 Oct 21 | r03        | ScarletsScarlets | 13 - 43 | MunsterMunster |
| |
| 15 Oct 21 | r04        | UlsterUlster | 26 - 10 | Lions Super RugbyLions Super R |
| 15 Oct 21 | r04        | DragonsDragons | 10 - 24 | StormersStormers |
| 16 Oct 21 | r04        | ZebreZebre | 6 - 17 | GlasgowGlasgow |
| 16 Oct 21 | r04        | BenettonBenetton | 26 - 29 | OspreysOspreys |
| 16 Oct 21 | r04        | LeinsterLeinster | 50 - 15 | ScarletsScarlets |
| 16 Oct 21 | r04        | EdinburghEdinburgh | 17 - 10 | Bulls Super RugbyBulls Super R |
| 16 Oct 21 | r04        | MunsterMunster | 20 - 18 | ConnachtConnacht |
| 16 Oct 21 | r04        | Cardiff RugbyCardiff Rugby | 23 - 17 | The SharksThe Sharks |
| |
| 22 Oct 21 | r05        | ScarletsScarlets | 34 - 28 | BenettonBenetton |
| 22 Oct 21 | r05        | GlasgowGlasgow | 15 - 31 | LeinsterLeinster |
| 23 Oct 21 | r05        | ZebreZebre | 10 - 27 | EdinburghEdinburgh |
| 23 Oct 21 | r05        | ConnachtConnacht | 36 - 11 | UlsterUlster |
| 23 Oct 21 | r05        | Cardiff RugbyCardiff Rugby | 31 - 29 | DragonsDragons |
| 23 Oct 21 | r05        | OspreysOspreys | 18 - 10 | MunsterMunster |
| |
| 26 Nov 21 | r06        | ConnachtConnacht | 46 - 18 | OspreysOspreys |
| 27 Nov 21 | r06        | BenettonBenetton | 19 - 18 | GlasgowGlasgow |
| 27 Nov 21 | r06        | DragonsDragons | 14 - 30 | EdinburghEdinburgh |
| 27 Nov 21 | r06        | LeinsterLeinster | 10 - 20 | UlsterUlster |
| |
| 03 Dec 21 | r05        | The SharksThe Sharks | 30 - 16 | Bulls Super RugbyBulls Super R |
| |
| 03 Dec 21 | r07        | EdinburghEdinburgh | 24 - 10 | BenettonBenetton |
| 03 Dec 21 | r07        | LeinsterLeinster | 47 - 19 | ConnachtConnacht |
| 04 Dec 21 | r07        | OspreysOspreys | 19 - 13 | UlsterUlster |
| |
| 04 Dec 21 | r08        | StormersStormers | 19 - 37 | Lions Super RugbyLions Super R |
| |
| 04 Dec 21 | r07        | GlasgowGlasgow | 33 - 14 | DragonsDragons |
| |
| 24 Dec 21 | r08        | ZebreZebre | 14 - 39 | BenettonBenetton |
| |
| 01 Jan 22 | r09        | ScarletsScarlets | 22 - 19 | OspreysOspreys |
| 01 Jan 22 | r09        | ConnachtConnacht | 10 - 8 | MunsterMunster |
| |
| 08 Jan 22 | r10        | EdinburghEdinburgh | 34 - 10 | Cardiff RugbyCardiff Rugby |
| 08 Jan 22 | r10        | GlasgowGlasgow | 38 - 19 | OspreysOspreys |
| 08 Jan 22 | r10        | MunsterMunster | 18 - 13 | UlsterUlster |
| |
| 22 Jan 22 | r05        | Lions Super RugbyLions Super R | 37 - 47 | The SharksThe Sharks |
| |
| 22 Jan 22 | r08        | Bulls Super RugbyBulls Super R | 26 - 30 | StormersStormers |
| |
| 28 Jan 22 | r11        | UlsterUlster | 27 - 15 | ScarletsScarlets |
| 28 Jan 22 | r11        | DragonsDragons | 13 - 13 | BenettonBenetton |
| 29 Jan 22 | r11        | Lions Super RugbyLions Super R | 10 - 34 | Bulls Super RugbyBulls Super R |
| 29 Jan 22 | r11        | ConnachtConnacht | 20 - 42 | GlasgowGlasgow |
| 29 Jan 22 | r11        | The SharksThe Sharks | 22 - 22 | StormersStormers |
| 29 Jan 22 | r11        | ZebreZebre | 17 - 34 | MunsterMunster |
| 29 Jan 22 | r11        | OspreysOspreys | 23 - 19 | EdinburghEdinburgh |
| 29 Jan 22 | r11        | Cardiff RugbyCardiff Rugby | 29 - 27 | LeinsterLeinster |
| |
| 04 Feb 22 | r08        | UlsterUlster | 32 - 12 | ConnachtConnacht |
| |
| 05 Feb 22 | r09        | Bulls Super RugbyBulls Super R | 21 - 13 | Lions Super RugbyLions Super R |
| 05 Feb 22 | r09        | StormersStormers | 20 - 10 | The SharksThe Sharks |
| |
| 11 Feb 22 | r08        | LeinsterLeinster | 26 - 7 | EdinburghEdinburgh |
| 11 Feb 22 | r08        | GlasgowGlasgow | 13 - 11 | MunsterMunster |
| |
| 12 Feb 22 | r12        | Lions Super RugbyLions Super R | 10 - 32 | StormersStormers |
| 12 Feb 22 | r12        | Bulls Super RugbyBulls Super R | 22 - 29 | The SharksThe Sharks |
| 18 Feb 22 | r12        | MunsterMunster | 34 - 20 | EdinburghEdinburgh |
| 19 Feb 22 | r12        | LeinsterLeinster | 29 - 7 | OspreysOspreys |
| 19 Feb 22 | r12        | GlasgowGlasgow | 13 - 3 | BenettonBenetton |
| 19 Feb 22 | r12        | ScarletsScarlets | 23 - 29 | ConnachtConnacht |
| 20 Feb 22 | r12        | DragonsDragons | 0 - 12 | UlsterUlster |
| |
| 25 Feb 22 | r10        | ZebreZebre | 7 - 45 | Bulls Super RugbyBulls Super R |
| 25 Feb 22 | r10        | LeinsterLeinster | 21 - 13 | Lions Super RugbyLions Super R |
| 26 Feb 22 | r10        | ConnachtConnacht | 19 - 17 | StormersStormers |
| 26 Feb 22 | r10        | BenettonBenetton | 7 - 29 | The SharksThe Sharks |
| |
| 04 Mar 22 | r13        | EdinburghEdinburgh | 56 - 8 | ConnachtConnacht |
| 04 Mar 22 | r13        | UlsterUlster | 48 - 12 | Cardiff RugbyCardiff Rugby |
| 05 Mar 22 | r13        | BenettonBenetton | 17 - 61 | LeinsterLeinster |
| 05 Mar 22 | r13        | MunsterMunster | 64 - 3 | DragonsDragons |
| 05 Mar 22 | r13        | ScarletsScarlets | 35 - 10 | GlasgowGlasgow |
| 06 Mar 22 | r13        | OspreysOspreys | 27 - 22 | ZebreZebre |
| |
| 11 Mar 22 | r06        | The SharksThe Sharks | 37 - 20 | ScarletsScarlets |
| 12 Mar 22 | r06        | Bulls Super RugbyBulls Super R | 29 - 24 | MunsterMunster |
| |
| 12 Mar 22 | r09        | UlsterUlster | 18 - 13 | LeinsterLeinster |
| |
| 13 Mar 22 | r06        | Lions Super RugbyLions Super R | 37 - 20 | Cardiff RugbyCardiff Rugby |
| 13 Mar 22 | r06        | StormersStormers | 55 - 7 | ZebreZebre |
| |
| 18 Mar 22 | r07        | Bulls Super RugbyBulls Super R | 57 - 12 | ScarletsScarlets |
| |
| 18 Mar 22 | r09        | GlasgowGlasgow | 30 - 17 | EdinburghEdinburgh |
| |
| 19 Mar 22 | r07        | Lions Super RugbyLions Super R | 23 - 21 | MunsterMunster |
| 19 Mar 22 | r07        | The SharksThe Sharks | 38 - 6 | ZebreZebre |
| 20 Mar 22 | r07        | StormersStormers | 40 - 3 | Cardiff RugbyCardiff Rugby |
| |
| 25 Mar 22 | r14        | Lions Super RugbyLions Super R | 45 - 15 | OspreysOspreys |
| 25 Mar 22 | r14        | MunsterMunster | 51 - 22 | BenettonBenetton |
| 26 Mar 22 | r14        | StormersStormers | 23 - 20 | UlsterUlster |
| 26 Mar 22 | r14        | ZebreZebre | 24 - 41 | ScarletsScarlets |
| 26 Mar 22 | r14        | The SharksThe Sharks | 5 - 21 | EdinburghEdinburgh |
| 26 Mar 22 | r14        | Bulls Super RugbyBulls Super R | 55 - 20 | DragonsDragons |
| 26 Mar 22 | r14        | Cardiff RugbyCardiff Rugby | 32 - 28 | GlasgowGlasgow |
| 26 Mar 22 | r14        | ConnachtConnacht | 8 - 45 | LeinsterLeinster |
| |
| 01 Apr 22 | r15        | The SharksThe Sharks | 51 - 3 | DragonsDragons |
| 01 Apr 22 | r15        | GlasgowGlasgow | 40 - 12 | ZebreZebre |
| 02 Apr 22 | r15        | BenettonBenetton | 17 - 21 | ConnachtConnacht |
| 02 Apr 22 | r15        | Bulls Super RugbyBulls Super R | 34 - 16 | UlsterUlster |
| 02 Apr 22 | r15        | Lions Super RugbyLions Super R | 15 - 9 | EdinburghEdinburgh |
| 02 Apr 22 | r15        | StormersStormers | 29 - 13 | OspreysOspreys |
| 02 Apr 22 | r15        | MunsterMunster | 19 - 34 | LeinsterLeinster |
| 02 Apr 22 | r15        | ScarletsScarlets | 35 - 20 | Cardiff RugbyCardiff Rugby |
| |
| 09 Apr 22 | r13        | StormersStormers | 19 - 17 | Bulls Super RugbyBulls Super R |
| 09 Apr 22 | r13        | The SharksThe Sharks | 37 - 10 | Lions Super RugbyLions Super R |
| |
| 09 Apr 22 | r08        | Cardiff RugbyCardiff Rugby | 14 - 49 | ScarletsScarlets |
| |
| 16 Apr 22 | r10        | ScarletsScarlets | 27 - 38 | DragonsDragons |
| |
| 22 Apr 22 | r16        | StormersStormers | 32 - 7 | GlasgowGlasgow |
| 22 Apr 22 | r16        | UlsterUlster | 17 - 24 | MunsterMunster |
| 22 Apr 22 | r16        | EdinburghEdinburgh | 29 - 26 | ZebreZebre |
| 23 Apr 22 | r16        | Bulls Super RugbyBulls Super R | 46 - 29 | BenettonBenetton |
| 23 Apr 22 | r16        | DragonsDragons | 19 - 38 | ScarletsScarlets |
| 23 Apr 22 | r16        | Lions Super RugbyLions Super R | 30 - 33 | ConnachtConnacht |
| 23 Apr 22 | r16        | Cardiff RugbyCardiff Rugby | 6 - 22 | OspreysOspreys |
| 23 Apr 22 | r16        | The SharksThe Sharks | 28 - 23 | LeinsterLeinster |
| |
| 29 Apr 22 | r17        | Bulls Super RugbyBulls Super R | 29 - 17 | GlasgowGlasgow |
| 29 Apr 22 | r17        | MunsterMunster | 42 - 21 | Cardiff RugbyCardiff Rugby |
| 30 Apr 22 | r17        | Lions Super RugbyLions Super R | 37 - 29 | BenettonBenetton |
| 30 Apr 22 | r17        | The SharksThe Sharks | 41 - 21 | ConnachtConnacht |
| 30 Apr 22 | r17        | ZebreZebre | 23 - 18 | DragonsDragons |
| 30 Apr 22 | r17        | StormersStormers | 20 - 13 | LeinsterLeinster |
| 30 Apr 22 | r17        | OspreysOspreys | 54 - 36 | ScarletsScarlets |
| 30 Apr 22 | r17        | EdinburghEdinburgh | 10 - 16 | UlsterUlster |
| |
| 06 May 22 | r12        | Cardiff RugbyCardiff Rugby | 42 - 14 | ZebreZebre |
| |
| 08 May 22 | r08        | OspreysOspreys | 50 - 31 | DragonsDragons |
| |
| 13 May 22 | r09        | DragonsDragons | 18 - 19 | Cardiff RugbyCardiff Rugby |
| 14 May 22 | r09        | BenettonBenetton | 39 - 17 | ZebreZebre |
| |
| 20 May 22 | r18        | BenettonBenetton | 69 - 21 | Cardiff RugbyCardiff Rugby |
| 20 May 22 | r18        | UlsterUlster | 24 - 21 | The SharksThe Sharks |
| 20 May 22 | r18        | OspreysOspreys | 31 - 38 | Bulls Super RugbyBulls Super R |
| 21 May 22 | r18        | DragonsDragons | 11 - 21 | Lions Super RugbyLions Super R |
| 21 May 22 | r18        | ConnachtConnacht | 22 - 20 | ZebreZebre |
| 21 May 22 | r18        | ScarletsScarlets | 21 - 26 | StormersStormers |
| 21 May 22 | r18        | EdinburghEdinburgh | 28 - 11 | GlasgowGlasgow |
| 21 May 22 | r18        | LeinsterLeinster | 35 - 25 | MunsterMunster |
| |
| 03 Jun 22 | QF        | UlsterUlster | 36 - 17 | MunsterMunster |
| 04 Jun 22 | QF        | Bulls Super RugbyBulls Super R | 30 - 27 | The SharksThe Sharks |
| 04 Jun 22 | QF        | LeinsterLeinster | 76 - 14 | GlasgowGlasgow |
| 04 Jun 22 | QF        | StormersStormers | 28 - 17 | EdinburghEdinburgh |
| |
| 10 Jun 22 | SF        | LeinsterLeinster | 26 - 27 | Bulls Super RugbyBulls Super R |
| 11 Jun 22 | SF        | StormersStormers | 17 - 15 | UlsterUlster |
| |
| 18 Jun 22 | Final        | Bulls Super RugbyBulls Super R | 18 - 13 | StormersStormers |