


| 03 Oct 20 | r01 | ScarletsScarlets | 27 - 30 | MunsterMunster |
| 11 Oct 20 | r02 | GlasgowGlasgow | 20 - 7 | ScarletsScarlets |
| 23 Oct 20 | r03 | BenettonBenetton | 3 - 10 | ScarletsScarlets |
| 01 Nov 20 | r04 | ScarletsScarlets | 3 - 6 | EdinburghEdinburgh |
| 08 Nov 20 | r05 | ScarletsScarlets | 18 - 17 | ZebreZebre |
| 14 Nov 20 | r06 | ConnachtConnacht | 14 - 20 | ScarletsScarlets |
| 22 Nov 20 | r07 | UlsterUlster | 26 - 24 | ScarletsScarlets |
| 26 Dec 20 | r09 | OspreysOspreys | 14 - 16 | ScarletsScarlets |
| 01 Jan 21 | r10 | ScarletsScarlets | 20 - 3 | DragonsDragons |
| 09 Jan 21 | r11 | Cardiff BluesCardiff Blues | 29 - 20 | ScarletsScarlets |
| 22 Jan 21 | r14 | ScarletsScarlets | 10 - 13 | Cardiff RugbyCardiff Rugby |
| 30 Jan 21 | r08 | ScarletsScarlets | 25 - 52 | LeinsterLeinster |
| 20 Feb 21 | r12 | ScarletsScarlets | 41 - 17 | BenettonBenetton |
| 27 Feb 21 | r13 | EdinburghEdinburgh | 25 - 27 | ScarletsScarlets |
| 12 Mar 21 | r15 | MunsterMunster | 28 - 10 | ScarletsScarlets |
| 22 Mar 21 | r16 | ScarletsScarlets | 41 - 36 | ConnachtConnacht |