


| 03 Oct 20 | r01 | EdinburghEdinburgh | 10 - 25 | OspreysOspreys |
| 10 Oct 20 | r02 | OspreysOspreys | 12 - 24 | UlsterUlster |
| 24 Oct 20 | r03 | OspreysOspreys | 23 - 15 | GlasgowGlasgow |
| 02 Nov 20 | r04 | ZebreZebre | 23 - 17 | OspreysOspreys |
| 08 Nov 20 | r05 | OspreysOspreys | 7 - 26 | LeinsterLeinster |
| 15 Nov 20 | r06 | MunsterMunster | 38 - 22 | OspreysOspreys |
| 22 Nov 20 | r07 | OspreysOspreys | 24 - 22 | BenettonBenetton |
| 26 Dec 20 | r09 | OspreysOspreys | 14 - 16 | ScarletsScarlets |
| 01 Jan 21 | r10 | Cardiff BluesCardiff Blues | 3 - 17 | OspreysOspreys |
| 09 Jan 21 | r11 | DragonsDragons | 20 - 28 | OspreysOspreys |
| 24 Jan 21 | r08 | ConnachtConnacht | 20 - 26 | OspreysOspreys |
| 20 Feb 21 | r12 | OspreysOspreys | 10 - 0 | ZebreZebre |
| 26 Feb 21 | r13 | UlsterUlster | 21 - 7 | OspreysOspreys |
| 06 Mar 21 | r14 | OspreysOspreys | 20 - 31 | DragonsDragons |
| 12 Mar 21 | r15 | GlasgowGlasgow | 30 - 25 | OspreysOspreys |
| 19 Mar 21 | r16 | LeinsterLeinster | 19 - 24 | OspreysOspreys |