


| 03 Oct 20 | r01 | EdinburghEdinburgh | 10 - 25 | OspreysOspreys |
| 10 Oct 20 | r02 | MunsterMunster | 25 - 23 | EdinburghEdinburgh |
| 25 Oct 20 | r03 | EdinburghEdinburgh | 26 - 37 | ConnachtConnacht |
| 01 Nov 20 | r04 | ScarletsScarlets | 3 - 6 | EdinburghEdinburgh |
| 09 Nov 20 | r05 | EdinburghEdinburgh | 18 - 0 | Cardiff BluesCardiff Blues |
| 16 Nov 20 | r06 | LeinsterLeinster | 50 - 10 | EdinburghEdinburgh |
| 30 Nov 20 | r08 | EdinburghEdinburgh | 14 - 43 | UlsterUlster |
| 08 Jan 21 | r10 | EdinburghEdinburgh | P - P | GlasgowGlasgow |
| 09 Jan 21 | r11 | ZebreZebre | P - P | EdinburghEdinburgh |
| 16 Jan 21 | r09 | GlasgowGlasgow | 23 - 22 | EdinburghEdinburgh |
| 23 Jan 21 | r11 | ZebreZebre | 10 - 26 | EdinburghEdinburgh |
| 20 Feb 21 | r12 | EdinburghEdinburgh | 10 - 22 | MunsterMunster |
| 27 Feb 21 | r13 | EdinburghEdinburgh | 25 - 27 | ScarletsScarlets |
| 07 Mar 21 | r14 | EdinburghEdinburgh | - | BenettonBenetton |
| 13 Mar 21 | r15 | ConnachtConnacht | 14 - 15 | EdinburghEdinburgh |
| 22 Mar 21 | r16 | Cardiff RugbyCardiff Rugby | 34 - 15 | EdinburghEdinburgh |
| 28 Mar 21 | r07 | DragonsDragons | 24 - 17 | EdinburghEdinburgh |