| 02 Oct 20 | r01        | ZebreZebre | 6 - 16 | Cardiff BluesCardiff Blues |
| |
| 10 Oct 20 | r02        | Cardiff BluesCardiff Blues | 29 - 7 | ConnachtConnacht |
| |
| 26 Oct 20 | r03        | MunsterMunster | 38 - 27 | Cardiff BluesCardiff Blues |
| |
| 02 Nov 20 | r04        | Cardiff BluesCardiff Blues | 7 - 11 | UlsterUlster |
| |
| 09 Nov 20 | r05        | EdinburghEdinburgh | 18 - 0 | Cardiff BluesCardiff Blues |
| |
| 16 Nov 20 | r06        | Cardiff BluesCardiff Blues | 22 - 5 | BenettonBenetton |
| |
| 22 Nov 20 | r07        | LeinsterLeinster | 40 - 5 | Cardiff BluesCardiff Blues |
| |
| 29 Nov 20 | r08        | Cardiff BluesCardiff Blues | 10 - 19 | GlasgowGlasgow |
| |
| 26 Dec 20 | r09        | DragonsDragons | 12 - 13 | Cardiff BluesCardiff Blues |
| |
| 01 Jan 21 | r10        | Cardiff BluesCardiff Blues | 3 - 17 | OspreysOspreys |
| |
| 09 Jan 21 | r11        | Cardiff BluesCardiff Blues | 29 - 20 | ScarletsScarlets |
| |
| 22 Jan 21 | r14        | ScarletsScarlets | 10 - 13 | Cardiff RugbyCardiff Rugby |
| |
| 20 Feb 21 | r12        | ConnachtConnacht | 32 - 17 | Cardiff RugbyCardiff Rugby |
| |
| 26 Feb 21 | r13        | Cardiff RugbyCardiff Rugby | 11 - 20 | MunsterMunster |
| |
| 14 Mar 21 | r15        | BenettonBenetton | 14 - 29 | Cardiff RugbyCardiff Rugby |
| |
| 22 Mar 21 | r16        | Cardiff RugbyCardiff Rugby | 34 - 15 | EdinburghEdinburgh |