| 04 Sep 10 | r01        | Cardiff BluesCardiff Blues | 34 - 23 | EdinburghEdinburgh |
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| 11 Sep 10 | r02        | LeinsterLeinster | 34 - 23 | Cardiff BluesCardiff Blues |
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| 18 Sep 10 | r03        | Cardiff BluesCardiff Blues | 43 - 21 | DragonsDragons |
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| 24 Sep 10 | r04        | BenettonBenetton | 7 - 19 | Cardiff BluesCardiff Blues |
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| 30 Sep 10 | r05        | Cardiff BluesCardiff Blues | 22 - 6 | ConnachtConnacht |
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| 22 Oct 10 | r06        | Cardiff BluesCardiff Blues | 10 - 16 | ScarletsScarlets |
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| 21 Nov 10 | r08        | Cardiff BluesCardiff Blues | 15 - 37 | UlsterUlster |
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| 27 Nov 10 | r09        | Cardiff BluesCardiff Blues | 38 - 6 | GlasgowGlasgow |
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| 04 Dec 10 | r10        | MunsterMunster | 16 - 9 | Cardiff BluesCardiff Blues |
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| 31 Dec 10 | r12        | Cardiff BluesCardiff Blues | 27 - 25 | OspreysOspreys |
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| 11 Feb 11 | r14        | GlasgowGlasgow | 15 - 26 | Cardiff BluesCardiff Blues |
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| 19 Feb 11 | r15        | Cardiff BluesCardiff Blues | 11 - 3 | LeinsterLeinster |
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| 25 Feb 11 | r16        | UlsterUlster | 32 - 13 | Cardiff BluesCardiff Blues |
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| 04 Mar 11 | r17        | EdinburghEdinburgh | 11 - 16 | Cardiff BluesCardiff Blues |
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| 25 Mar 11 | r18        | Cardiff BluesCardiff Blues | 15 - 16 | MunsterMunster |
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| 02 Apr 11 | r19        | OspreysOspreys | 21 - 21 | Cardiff BluesCardiff Blues |
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| 15 Apr 11 | r20        | ConnachtConnacht | 12 - 26 | Cardiff BluesCardiff Blues |
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| 21 Apr 11 | r21        | Cardiff BluesCardiff Blues | 29 - 9 | BenettonBenetton |
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| 29 Apr 11 | r11        | DragonsDragons | 28 - 15 | Cardiff BluesCardiff Blues |
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| 06 May 11 | r22        | ScarletsScarlets | 38 - 23 | Cardiff BluesCardiff Blues |