| 02 Oct 20 | r01        | ZebreZebre | 6 - 16 | Cardiff BluesCardiff Blues |
| 02 Oct 20 | r01        | LeinsterLeinster | 35 - 5 | DragonsDragons |
| 02 Oct 20 | r01        | UlsterUlster | 35 - 24 | BenettonBenetton |
| 03 Oct 20 | r01        | ScarletsScarlets | 27 - 30 | MunsterMunster |
| 03 Oct 20 | r01        | ConnachtConnacht | 28 - 24 | GlasgowGlasgow |
| 03 Oct 20 | r01        | EdinburghEdinburgh | 10 - 25 | OspreysOspreys |
| |
| 09 Oct 20 | r02        | DragonsDragons | 26 - 18 | ZebreZebre |
| 10 Oct 20 | r02        | BenettonBenetton | 25 - 37 | LeinsterLeinster |
| 10 Oct 20 | r02        | OspreysOspreys | 12 - 24 | UlsterUlster |
| 10 Oct 20 | r02        | Cardiff BluesCardiff Blues | 29 - 7 | ConnachtConnacht |
| 10 Oct 20 | r02        | MunsterMunster | 25 - 23 | EdinburghEdinburgh |
| 11 Oct 20 | r02        | GlasgowGlasgow | 20 - 7 | ScarletsScarlets |
| |
| 23 Oct 20 | r03        | LeinsterLeinster | 63 - 8 | ZebreZebre |
| 23 Oct 20 | r03        | BenettonBenetton | 3 - 10 | ScarletsScarlets |
| 24 Oct 20 | r03        | OspreysOspreys | 23 - 15 | GlasgowGlasgow |
| 25 Oct 20 | r03        | UlsterUlster | 40 - 17 | DragonsDragons |
| 25 Oct 20 | r03        | EdinburghEdinburgh | 26 - 37 | ConnachtConnacht |
| 26 Oct 20 | r03        | MunsterMunster | 38 - 27 | Cardiff BluesCardiff Blues |
| |
| 01 Nov 20 | r04        | DragonsDragons | 16 - 28 | MunsterMunster |
| 01 Nov 20 | r04        | ScarletsScarlets | 3 - 6 | EdinburghEdinburgh |
| 02 Nov 20 | r04        | Cardiff BluesCardiff Blues | 7 - 11 | UlsterUlster |
| 02 Nov 20 | r04        | ZebreZebre | 23 - 17 | OspreysOspreys |
| 02 Nov 20 | r04        | GlasgowGlasgow | 19 - 32 | LeinsterLeinster |
| |
| 08 Nov 20 | r05        | OspreysOspreys | 7 - 26 | LeinsterLeinster |
| 08 Nov 20 | r05        | ScarletsScarlets | 18 - 17 | ZebreZebre |
| 09 Nov 20 | r05        | EdinburghEdinburgh | 18 - 0 | Cardiff BluesCardiff Blues |
| 09 Nov 20 | r05        | UlsterUlster | 40 - 15 | GlasgowGlasgow |
| |
| 14 Nov 20 | r06        | ConnachtConnacht | 14 - 20 | ScarletsScarlets |
| 15 Nov 20 | r06        | MunsterMunster | 38 - 22 | OspreysOspreys |
| 16 Nov 20 | r06        | ZebreZebre | 14 - 57 | UlsterUlster |
| 16 Nov 20 | r06        | Cardiff BluesCardiff Blues | 22 - 5 | BenettonBenetton |
| 16 Nov 20 | r06        | LeinsterLeinster | 50 - 10 | EdinburghEdinburgh |
| |
| 22 Nov 20 | r07        | OspreysOspreys | 24 - 22 | BenettonBenetton |
| 22 Nov 20 | r07        | ZebreZebre | 12 - 47 | ConnachtConnacht |
| 22 Nov 20 | r07        | LeinsterLeinster | 40 - 5 | Cardiff BluesCardiff Blues |
| 22 Nov 20 | r07        | UlsterUlster | 26 - 24 | ScarletsScarlets |
| 23 Nov 20 | r07        | GlasgowGlasgow | 13 - 27 | MunsterMunster |
| |
| 29 Nov 20 | r08        | BenettonBenetton | 19 - 26 | DragonsDragons |
| 29 Nov 20 | r08        | Cardiff BluesCardiff Blues | 10 - 19 | GlasgowGlasgow |
| 30 Nov 20 | r08        | EdinburghEdinburgh | 14 - 43 | UlsterUlster |
| 30 Nov 20 | r08        | MunsterMunster | 52 - 3 | ZebreZebre |
| |
| 04 Dec 20 | r04        | ConnachtConnacht | 31 - 14 | BenettonBenetton |
| |
| 05 Dec 20 | r06        | GlasgowGlasgow | 22 - 23 | DragonsDragons |
| |
| 26 Dec 20 | r09        | DragonsDragons | 12 - 13 | Cardiff BluesCardiff Blues |
| 26 Dec 20 | r09        | OspreysOspreys | 14 - 16 | ScarletsScarlets |
| 26 Dec 20 | r09        | MunsterMunster | P - P | LeinsterLeinster |
| 27 Dec 20 | r09        | ConnachtConnacht | 19 - 32 | UlsterUlster |
| |
| 01 Jan 21 | r10        | ScarletsScarlets | 20 - 3 | DragonsDragons |
| 01 Jan 21 | r10        | Cardiff BluesCardiff Blues | 3 - 17 | OspreysOspreys |
| 02 Jan 21 | r10        | LeinsterLeinster | 24 - 35 | ConnachtConnacht |
| 02 Jan 21 | r10        | UlsterUlster | 15 - 10 | MunsterMunster |
| 08 Jan 21 | r10        | EdinburghEdinburgh | P - P | GlasgowGlasgow |
| |
| 08 Jan 21 | r11        | LeinsterLeinster | 24 - 12 | UlsterUlster |
| |
| 09 Jan 21 | r10        | BenettonBenetton | 22 - 18 | ZebreZebre |
| |
| 09 Jan 21 | r11        | GlasgowGlasgow | P - P | BenettonBenetton |
| 09 Jan 21 | r11        | ZebreZebre | P - P | EdinburghEdinburgh |
| 09 Jan 21 | r11        | DragonsDragons | 20 - 28 | OspreysOspreys |
| 09 Jan 21 | r11        | Cardiff BluesCardiff Blues | 29 - 20 | ScarletsScarlets |
| 09 Jan 21 | r11        | ConnachtConnacht | 10 - 16 | MunsterMunster |
| |
| 16 Jan 21 | r09        | GlasgowGlasgow | 23 - 22 | EdinburghEdinburgh |
| |
| 22 Jan 21 | r14        | ScarletsScarlets | 10 - 13 | Cardiff RugbyCardiff Rugby |
| |
| 23 Jan 21 | r11        | ZebreZebre | 10 - 26 | EdinburghEdinburgh |
| |
| 23 Jan 21 | r09        | MunsterMunster | 10 - 13 | LeinsterLeinster |
| |
| 24 Jan 21 | r08        | ConnachtConnacht | 20 - 26 | OspreysOspreys |
| |
| 30 Jan 21 | r05        | BenettonBenetton | 16 - 18 | MunsterMunster |
| |
| 30 Jan 21 | r08        | ScarletsScarlets | 25 - 52 | LeinsterLeinster |
| |
| 05 Feb 21 | r05        | DragonsDragons | 20 - 30 | ConnachtConnacht |
| |
| 19 Feb 21 | r12        | GlasgowGlasgow | 13 - 19 | UlsterUlster |
| 19 Feb 21 | r12        | DragonsDragons | 29 - 35 | LeinsterLeinster |
| 20 Feb 21 | r12        | ScarletsScarlets | 41 - 17 | BenettonBenetton |
| 20 Feb 21 | r12        | OspreysOspreys | 10 - 0 | ZebreZebre |
| 20 Feb 21 | r12        | EdinburghEdinburgh | 10 - 22 | MunsterMunster |
| 20 Feb 21 | r12        | ConnachtConnacht | 32 - 17 | Cardiff RugbyCardiff Rugby |
| |
| 26 Feb 21 | r13        | BenettonBenetton | 17 - 19 | ConnachtConnacht |
| 26 Feb 21 | r13        | Cardiff RugbyCardiff Rugby | 11 - 20 | MunsterMunster |
| 26 Feb 21 | r13        | UlsterUlster | 21 - 7 | OspreysOspreys |
| 27 Feb 21 | r13        | EdinburghEdinburgh | 25 - 27 | ScarletsScarlets |
| 27 Feb 21 | r13        | ZebreZebre | 26 - 15 | DragonsDragons |
| 28 Feb 21 | r13        | LeinsterLeinster | 40 - 21 | GlasgowGlasgow |
| |
| 05 Mar 21 | r14        | MunsterMunster | 20 - 17 | ConnachtConnacht |
| 06 Mar 21 | r14        | ZebreZebre | 20 - 31 | GlasgowGlasgow |
| 06 Mar 21 | r14        | OspreysOspreys | 20 - 31 | DragonsDragons |
| 06 Mar 21 | r14        | UlsterUlster | 19 - 38 | LeinsterLeinster |
| 07 Mar 21 | r14        | EdinburghEdinburgh | - | BenettonBenetton |
| |
| 12 Mar 21 | r15        | ZebreZebre | 31 - 48 | LeinsterLeinster |
| 12 Mar 21 | r15        | MunsterMunster | 28 - 10 | ScarletsScarlets |
| 12 Mar 21 | r15        | GlasgowGlasgow | 30 - 25 | OspreysOspreys |
| 13 Mar 21 | r15        | DragonsDragons | 22 - 26 | UlsterUlster |
| 13 Mar 21 | r15        | ConnachtConnacht | 14 - 15 | EdinburghEdinburgh |
| 14 Mar 21 | r15        | BenettonBenetton | 14 - 29 | Cardiff RugbyCardiff Rugby |
| |
| 19 Mar 21 | r16        | MunsterMunster | 31 - 17 | BenettonBenetton |
| 19 Mar 21 | r16        | UlsterUlster | 49 - 3 | ZebreZebre |
| 19 Mar 21 | r16        | LeinsterLeinster | 19 - 24 | OspreysOspreys |
| 21 Mar 21 | r16        | DragonsDragons | 26 - 17 | GlasgowGlasgow |
| 22 Mar 21 | r16        | Cardiff RugbyCardiff Rugby | 34 - 15 | EdinburghEdinburgh |
| 22 Mar 21 | r16        | ScarletsScarlets | 41 - 36 | ConnachtConnacht |
| |
| 27 Mar 21 | r11        | GlasgowGlasgow | 46 - 25 | BenettonBenetton |
| |
| 27 Mar 21 | Final        | LeinsterLeinster | 16 - 6 | MunsterMunster |
| |
| 28 Mar 21 | r07        | DragonsDragons | 24 - 17 | EdinburghEdinburgh |